Determination of the saffron on MCF-7 and MCF-12a cell lines

Year 2022, Volume: 4 Issue: 3, 47 - 55, 03.01.2023

Aybüke Afra Keskiner , Berna Kocaman

https://doi.org/10.55895/sshs.1219135

Abstract

Cancer is recognized as a major threat to health in the world, where response to treatment varies. Recently, there has been a great interest in the inhibitory role of herbs and spices in tumor growth inhibition and cancer progression. Saffron, also called 'red gold', is an aromatic medicinal herb. Saffron's medicinal virtues, ease of use in the kitchen, and its phytochemical profile have led to further investigation of its biological and therapeutic properties. Saffron is rich in carotenoids. Many studies have investigated the effect of saffron and its active ingredients in the prevention and treatment of cancer. Today, the mechanism of action of saffron has not yet been clarified. The aim of this study was to determine the anticancer and antitoxic effects of saffron as a chemo-inhibitory herb in MCF-7 and MCF-12a cell lines, respectively.

Keywords

Saffron, Cytotoxicity, Breast cancer

References

• Abdullaev, F. I. (2002). Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus L.). Experimental biology and medicine, 227(1), 20-25.
• Abu-Izneid, T., Rauf, A., Khalil, A. A., Olatunde, A., Khalid, A., Alhumaydhi, F. A. and Rengasamy, K. R. (2022). Nutritional and health beneficial properties of saffron (Crocus sativus L): A comprehensive review. Critical Reviews in Food Science and Nutrition, 62(10), 2683-2706.
• Anand, P., Kunnumakara, A. B., Sundaram, C., Harikumar, K. B., Tharakan, S. T., Lai, O. S., and Aggarwal, B. B. (2008). Cancer is a preventable disease that requires major lifestyle changes. Pharmaceutical research, 25(9), 2097-2116.
• Bukhari, S. I., Din, I., Grewal, S. and Dhar, M. K. (2018). Antiproliferative effect of saffron and its constituents on different cancerous cell lines. Pharmacognosy Research, 10(3).
• Butnariu, M., Quispe, C., Herrera-Bravo, J., Sharifi-Rad, J., Singh, L., Aborehab, N. M. and Cho, W. C. (2022). The pharmacological activities of Crocus sativus L.: a review based on the mechanisms and therapeutic opportunities of its phytoconstituents. Oxidative medicine and cellular longevity.
• Jalil Tavakkol-Afshari, Azam Brook, Seyed Hadi Mousavi, Study of cytotoxic and apoptogenic properties of saffron extract in human cancer cell lines, Food and Chemical Toxicology, Volume 46, Issue 11, 2008, Pages 3443-3447, ISSN 0278-6915.
• Milajerdi, A., Djafarian, K. and Hosseini, B. (2016). The toxicity of saffron (Crocus sativus L.) and its constituents against normal and cancer cells. Journal of nutrition & intermediary metabolism, 3, 23-32.
• Parizadeh, M. R., GHAFOORI, G. F., Abbaspour, A. R., TAVAKOL, A. J. and HAYOUR, M. M. (2011). Effects of aqueous saffron extract on nitric oxide production by two human carcinoma cell lines: Hepatocellular carcinoma (HepG2) and laryngeal carcinoma (Hep2). Peto, J. (2001). Cancer epidemiology in the last century and the next decade. Nature, 411(6835), 390-395.
• Salek, R., Dehghani, M., Mohajeri, S. A., Talaei, A., Fanipakdel, A. and Javadinia, S. A. (2021). Amelioration of anxiety, depression, and chemotherapy related toxicity after crocin administration during chemotherapy of breast cancer: a double blind, randomized clinical trial. Phytotherapy Research, 35(9), 5143-5153.
• Wali, A. F., Alchamat, H. A. A., Hariri, H. K., Hariri, B. K., Menezes, G. A., Zehra, U. and Ahmad, P. (2020). Antioxidant, antimicrobial, antidiabetic and cytotoxic activity of Crocus sativus L. petals. Applied Sciences, 10(4), 1519.
• Wang, C. Z., Ma, Q., Kim, S., Wang, D. H., Shoyama, Y. and Yuan, C. S. (2022). Effects of saffron and its active constituent crocin on cancer management: a narrative review. evaluation, 6, 7.