Determination of Brucellosis Seroprevalence and Associated Risk Factors in Amasya Province

Year 2023, Volume: 5 Issue: 3, 15 - 30, 31.12.2023

Berkhan Topaktaş , Aslı Memiş , Zeliha Karapelit , Elif Menekşe , Fikriye Milletli Sezgin , Meryem Çetin

https://doi.org/10.55895/sshs.1371133

Abstract

Objective: It is important to determine the current seroprevalence by investigating Brucellosis disease, which is an important cause of morbidity, in the general population. In this study, it was aimed to determine brucellosis seroprevalence and associated risk factors in the population residing in the city center of Amasya.
Materiels and Methods: The population of this study consisted of the population aged fifteen and over living in the city center of Amasya. For the cross-sectional study, it was aimed to reach 464 people with the multi-stage sampling method. As a cluster unit, villages representing rural areas and family health centers representing neighborhoods in urban areas were taken. The data of the study were collected between 16/05/2022-22/02/2023. After the individuals included in the sample were informed about the purpose of the study and the procedures to be applied, a questionnaire form prepared by the researchers was applied to those who agreed to participate. Following the application of the questionnaire, venous blood sample was taken and specific immunoglobulins were investigated by Brucellacapt test in serum sample. Statistical significance level was accepted as p<0.05 for all tests.
Results: Brucellosis seroprevalence was found to be 0.8% as a result of the study. It was determined that 4 seropositive cases were between the ages of 48-78 and all of them resided in rural areas (p=0.025). It was determined that 263 (55.6%) of the participants had not heard of Brucellosis before. The rate of being aware of Brucellosis disease was higher in people living in rural areas and having a high school or higher education level (p=0.028 and p=0.002, respectively). While 103 (49.0%) of the people who heard of brucellosis disease did not know any symptoms of the disease, the number of people who stated that they consumed food made from raw or unboiled milk in the last year was found to be 244 (51.3%).
Conclusion: Considering that the disease is transmitted by aerosol from the barns where the sick animals are located, in addition to direct contact, it is necessary to inform the individuals dealing with animal husbandry to take adequate precautions. The fact that the rate of being aware of brucellosis is lower among those living in urban areas and those with secondary school education or below indicates that more educational studies on the disease should be carried out by targeting these segments in particular.

Keywords

brucellosis, seroprevalence, risk factors

Supporting Institution

Amasya Üniversitesi Bilimsel Araştırma Proje birimi

Project Number

FMB-BAP 21-0505

Thanks

Katkılarından dolayı tüm yazarlara ve Amasya Üniversitesi Bilimsel Araştırma Proje birimine teşekkür ederim.

References

• Akkuș Y, Karatay G, Gülmez A. (2011). Hayvancılıkla uğrașan bireylerin bruselloza ilișkin bilgi ve uygulamaları. Kafkas J Med Sci;1(1):16-20.
• Alkan S, Demiray EKD, Sıddıkoğlu D, ve ark. (2022). Kırsal kesimde yaşayan kişilerin brusella enfeksiyonu bulaş yolları hakkındaki bilgi düzeylerinin değerlendirilmesi. International Anatolia Academic Online Journal Health Sciences; 8 (1): 98-113.
• Avcı DK, Şahin HA, Güvendi G, Çakmak Z. (2017). Van iline bağlı bir köyde hayvancılıkla uğraşan bireylerde Bruselloz’a ilişkin bilgi, tutum ve davranışların belirlenmesi. Van Tıp Dergisi; 24:78-84.
• Avijgan M, Rostamnezhad M, Jahanbani-Ardakani H. (2019). Clinical and serological approach to patients with brucellosis: a common diagnostic dilemma and a worldwide perspective. Microbial Pathogenesis: 129:125-30.
• Babaoğlu Ü, Demir G. (2017). Yarı Kentsel Bölgede Yaşayan Kişilerin Brusella Hakkında Bilgi Durumları. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 2017 (4): 214. 2017;219.
• Casanova A, Ariza J, Rubio M, et al. (2009). BrucellaCapt versus classical tests in the serological diagnosis and management of human brucellosis. Clinical and Vaccine Immunology;16(6):844-51.
• CDC (2017). Brucellosis reference guide: exposures, testing, and prevention. Corbel MJ. (2006). Brucellosis in humans and animals: World Health Organization.
• Çakır Ş, Yıldırım M. (2018). Türkiye’de küçük ruminantlarda brusellozun kontrol ve eradikasyon stratejileri. Dicle Üniversitesi Veteriner Fakültesi Dergisi;11(2):98-104.
• El-Sayed A, Awad W. (2018) Brucellosis: Evolution and expected comeback. International Journal of Veterinary Science and Medicine. 6:S31-S5.
• Engindeniz S, Taşkin T, Gbadamonsi AA, et al. (2021). Tüketicilerin süt ve süt ürünleri tercihlerinin analizi. Tekirdağ Ziraat Fakültesi Dergisi 2021;18(3):470-81.
• Haque N, Bari M, Hossain M, et al. (2011). An overview of Brucellosis. Mymensingh Medical Journal: MMJ;20(4):742-7.
• Kaygisiz A, Özkan İ. (2021). Samsun Tekkeköy ilçesindeki süt sığırcılık işletmelerinin yapısal özellikleri ve hijyen koşulları. Harran Tarım ve Gıda Bilimleri Dergisi;25(2):225-33.
• Murat A, Köprülü ND, Ekerbiçer HÇ, ve ark. (2011). Kahramanmaraş il merkezinde bruselloz hastalığının seroprevalansı. Mersin Üniversitesi Sağlık Bilimleri Dergisi;4(1):17-23.
• Sağlık Bakanlığı (SB), Türkiye Halk Sağlığı Kurumu (2014). Bulaşıcı Hastalıklar Laboratuvar Tanı Rehberi, Mikrobiyoloji Referans Laboratuvarları Daire Başkanlığı, Ankara.
• SB. (2019). Türkiye Zoonotik Hastalıklar Eylem Planı (2019-2023). Ankara: Halk Sağlığı Genel Müdürlüğü Zoonotik ve Vektörel Hastalıklar Dairesi Başkanlığı.
• Sözen H, Gönen İ. (2012). Riskli bölgelerde bruselloz için serolojik tarama yapılmalı mı? SDU Journal of Health Science Institute/SDÜ Saglik Bilimleri Enstitüsü Dergisi;3(1).
• Şahin M, Nazlican E, Akbaba M. (2019). Hayvancılıkla uğraşanlarda zoonotik hastalıklarla ilgili bilgi, tutum ve davranış üzerine kesitsel bir çalışma. Sakarya Tıp Dergisi;9(3):426-32.
• Tavsan Ö, Tekin-Koruk S, Koruk I. (2015). Sanlıurfa il merkezinde bruselloz prevalansi ve iliskili risk faktörleri/The prevalence of brucellosis and associated risk factors in Sanlıurfa city center. Klimik Dergisi;28(1):11.
• TUİK (2021a). Hayvancılık istatistikleri, 2021. [cited 20/03/2023]. Available from: https://biruni.tuik.gov.tr/medas/?kn=101&locale=tr.
• TUİK (2021b). Adrese Dayalı Nüfus Kayıt İstatistikleri [cited 06/05/2021]. Available from: https://data.tuik.gov.tr/Kategori/GetKategori?p=Nufus-ve-Demografi-109.
• Turhan E, Inandi T, Çetin M. (2010). Hatay'da on bes yas üzeri toplumda bruselloz seroprevalansi ve risk faktörleri/brucellosis seroprevalance and risk factors in the population older than fifteen years in Hatay, Turkey. Türkiye Klinikleri Tip Bilimleri Dergisi;30(5):1631.
• Türkiye Belediyeler Birliği (TBB.) Ücretsiz Aşı Temini ve Uygulanması Protokolü 2022 [Available from: https://www.tbb.gov.tr/Tr/Haberler_ucretsiz-asi-temini-ve-uygulanmasi-protokolumzalandi_10553.
• Xu N, Qu C, Sai L, et al. (2023). Evaluating the efficacy of serological testing of clinical specimens collected from patients with suspected brucellosis. PLOS Neglected Tropical Diseases;17(2):e0011131.
• Yagupsky P, Morata P, Colmenero JD. (2019). Laboratory diagnosis of human brucellosis. Clinical Microbiology Reviews;33(1):e00073-19.
• Zhang N, Zhou H, Huang D-S, et al. (2019). Brucellosis awareness and knowledge in communities worldwide: A systematic review and meta-analysis of 79 observational studies. PLoS Neglected Tropical Diseases;13(5):e0007366