The Relationship of COMP and MMP-3 Levels with Radiographic and Clinical Findings in Knee Osteoarthritis

Year 2023, Volume: 32 Issue: 2, 130 - 138, 09.06.2023

Vildan Yıldız Yeşim Gökçe Kutsal , Sevilay Karahan , Zeliha Günnur Dikmen , Üstün Aydıngöz

https://doi.org/10.17942/sted.1198436

Abstract

Purpose: Osteoarthritis is the most common joint disease affecting the knee joints mostly. The aim of this study was to investigate the relationship between radiological stages of the disease and daily life activity levels of the patient and serum cartilage oligomeric matrix protein (COMP) and matrix metalloproteinase-3(MMP-3) levels in patients with knee osteoarthritis.
Material and Methods: Eighty-five patients were divided into three groups according to Kellgren-Lawrence scale. In the 1st group Stage I, in the 2nd group Stage II/III and in the 3rd group Stage IV patients were included. Visual Analog Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Lequesne algofunctional knee index, and Knee Injury and Osteoarthritis Outcome Score Short Form (KOOS-PS) were used to evaluate the severity of pain and functional status in daily life activities of patients.
Results: In all three patient groups serum COMP and MMP-3 levels were found to be similar. A weak correlation was found between serum COMP levels and VAS (p=0.682), Lequesne (p=0.941) scores. There was also a weak correlation between serum MMP-3 levels and VAS (p=0.911), Lequesne (p=0.636) and KOOS-PS (p=0.965).
Conclusion: No significant differences were found in serum COMP and MMP-3 levels between different radiological stages of knee osteoarthritis groups and the clinical parameters as severity of pain and functional status in daily life activities. Further studies with larger sample groups are needed on this issue.

Keywords

Knee, Osteoartritis, Radiography, COMP, MMP-3, Function, Pain

Diz Osteoartritinde COMP ve MMP-3 Düzeylerinin Radyografik ve Klinik Bulgularla İlişkisi

Abstract

Amaç: Osteoartrit, çoğunlukla dizleri etkileyen en yaygın eklem hastalığıdır. Bu çalışmanın amacı diz osteoartriti olan hastalarda hastalığın radyolojik evreleri ve hastanın günlük yaşam aktivite düzeyleri ile serum kıkırdak oligomerik matriks proteini (COMP) ve matriks metaloproteinaz-3 (MMP-3) düzeyleri arasındaki ilişkiyi araştırmaktır.
Materyal ve Metod: Seksen beş hasta Kellgren-Lawrence ölçeğine göre üç gruba ayrıldı. 1. grup Evre I, 2. grup Evre II/III ve 3. grup Evre IV hastalar dahil edildi. Hastaların günlük yaşam aktivitelerinde ağrı şiddetini ve fonksiyonel durumlarını değerlendirmek için Görsel Analog Skala (VAS), Western Ontario ve McMaster Üniversiteleri Osteoartrit İndeksi (WOMAC), Lequesne indeksi ve Diz Yaralanması ve Osteoartrit Sonuç Skoru Kısa Formu (KOOS-PS) kullanıldı.
Bulgular: Her üç hasta grubunda da serum COMP ve MMP-3 düzeyleri benzer bulundu. Serum COMP düzeyleri ile VAS (p=0.682), Lequesne (p=0.941) skorları arasında zayıf korelasyon saptandı. Serum MMP-3 düzeyleri ile VAS (p= 0.911), Lequesne (p=0.636) ve KOOS-PS (p=0.965) arasında da zayıf bir korelasyon olduğu belirlendi.
Sonuç: Diz osteoartrit gruplarının farklı radyolojik evreleri ile günlük yaşam aktivitelerinde ağrı şiddeti ve fonksiyonel durum olan klinik parametreler ile serum COMP ve MMP-3 düzeyleri arasında anlamlı farklılık saptanmadı.

Keywords

Diz, Osteoartrit, Radyografi, COMP, MMP-3, Fonksiyon, Ağrı

References

• Robinson WH, Lepus CM, Wang Q, Raghu H, Mao R, Lindstrom TM, et al. Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 2016;12(10):580-92.
• Zhuo Q, Yang W, Chen J, Wang Y. Metabolic syndrome meets osteoarthritis. Nat Rev Rheumatol. 2012;8(12):729-37.
• Yoshihara Y, Nakamura H, Obata K, Yamada H, Hayakawa T, Fujikawa K, et al. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis. Ann Rheum Dis. 2000;59(6):455-61.
• Connelly A, Tucker A, Kott L, Duncan A, Wright A. Serum biochemical markers of joint metabolism and inflammation in relation to clinical symptoms and physical function in adults with symptomatic knee osteoarthritis. Osteoarthritis and Cartilage. 2014;22:S66.
• Li W, Du C, Wang H, Zhang C. Increased serum ADAMTS-4 in knee osteoarthritis: a potential indicator for the diagnosis of osteoarthritis in early stages. Genet Mol Res. 2014;13(4):9642-9.
• Georgiev T, Ivanova M, Kopchev A, Velikova T, Miloshov A, Kurteva E, et al. Cartilage oligomeric protein, matrix metalloproteinase-3, and Coll2-1 as serum biomarkers in knee osteoarthritis: a cross-sectional study. Rheumatol Int. 2018;38(5):821-30.
• Kan H, Arai Y, Kobayashi M, Nakagawa S, Inoue H, Hino M, et al. Fixed-flexion view X-ray of the knee superior in detection and follow-up of knee osteoarthritis. Medicine (Baltimore). 2017;96(49):e9126.
• Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957;16(4):494-502.
• Gallagher EJ, Liebman M, Bijur PE. Prospective validation of clinically important changes in pain severity measured on a visual analog scale. Ann Emerg Med. 2001;38(6):633-8.
• Tuzun EH, Eker L, Aytar A, Daskapan A, Bayramoglu M. Acceptability, reliability, validity and responsiveness of the Turkish version of WOMAC osteoarthritis index. Osteoarthritis Cartilage. 2005;13(1):28-33.
• Basaran S, Guzel R, Seydaoglu G, Guler-Uysal F. Validity, reliability, and comparison of the WOMAC osteoarthritis index and Lequesne algofunctional index in Turkish patients with hip or knee osteoarthritis. Clinical rheumatology. 2010;29(7):749-56.
• Gul ED, Yilmaz O, Bodur H. Reliability and validity of the Turkish version of the knee injury and osteoarthritis outcome score-physical function short-form (KOOS-PS). J Back Musculoskelet Rehabil. 2013;26(4):461-6.
• Das Gupta E, Ng WR, Wong SF, Bhurhanudeen AK, Yeap SS. Correlation of serum cartilage oligometric matrix protein (COMP) and interleukin-16 (IL-16) levels with disease severity in primary knee osteoarthritis: A pilot study in a Malaysian population. PloS one 2017;12(9).
• Sharif M, Kirwan JR, Elson CJ, Granell R, Clarke S. Suggestion of nonlinear or phasic progression of knee osteoarthritis based on measurements of serum cartilage oligomeric matrix protein levels over five years. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology. 2004;50(8):2479-88.
• 1Vilım V, Olejarova M, Macháček S, Gatterova J, Kraus V, Pavelka K. Serum levels of cartilage oligomeric matrix protein (COMP) correlate with radiographic progression of knee osteoarthritis. Osteoarthritis and cartilage. 2002;10(9):707-13.
• 1Kraus VB, Collins JE, Hargrove D, Losina E, Nevitt M, Katz JN, et al. Predictive validity of biochemical biomarkers in knee osteoarthritis: data from the FNIH OA Biomarkers Consortium. Ann Rheum Dis. 2017;76(1):186-95.
• 1Hao HQ, Zhang JF, He QQ, Wang Z. Cartilage oligomeric matrix protein, C-terminal cross-linking telopeptide of type II collagen, and matrix metalloproteinase-3 as biomarkers for knee and hip osteoarthritis (OA) diagnosis: a systematic review and meta-analysis. Osteoarthritis Cartilage. 2019;27(5):726-36.
• Jordan JM, Luta G, Stabler T, Renner JB, Dragomir AD, Vilim V, et al. Ethnic and sex differences in serum levels of cartilage oligomeric matrix protein: the Johnston County Osteoarthritis Project. Arthritis & Rheumatism. 2003;48(3):675-81.
• 1Riegger J, Rehm M, Buchele G, Brenner H, Gunther KP, Rothenbacher D, et al. Serum Cartilage Oligomeric Matrix Protein in Late-Stage Osteoarthritis: Association with Clinical Features, Renal Function, and Cardiovascular Biomarkers. J Clin Med. 2020;9(1).
• Mundermann A, King KB, Smith RL, Andriacchi TP. Change in serum COMP concentration due to ambulatory load is not related to knee OA status. J Orthop Res. 2009;27(11):1408-13.
• Georgiev T, Inavova M, Velikova T, Stoilov R. Serum levels of matrix metalloproteinase-3 as a prognostic marker for progression of cartilage injury in patients with knee osteoarthritis. Acta Reumatol Port. 2020;45(3):207-213.
• Nelson AE, Smith MW, Golightly YM, Jordan JM. "Generalized osteoarthritis": a systematic review. Semin Arthritis Rheum. 2014;43(6):713-20.
• Matejova JP, Spakova T, Harvanova D. et al. A Preliminary Study of Combined Detection of COMP, TIMP-1, and MMP-3 in Synovial Fluid: Potential Indicators of Osteoarthritis Progression. Cartilage. 2021 Dec; 13(2 Suppl): 1421S–1430S.
• Jarecki J, Małecka-Masalska T, Kosior-Jarecka E et al. Concentration of Selected Metalloproteinases and Osteocalcin in the Serum and Synovial Fluid of Obese Women with Advanced Knee Osteoarthritis. Int. J. Environ. Res. Public Health 2022;19: 3530.