Propolis

Year 2022, Volume: 48 Issue: 1, 1 - 9, 25.04.2022

Semra Araba , Haluk Özparlak

https://doi.org/10.35238/sufefd.1068425

Abstract

Propolis önemli bir arı ürünüdür. Propolis antimikrobiyal, antikanser/antitümör, antioksidan, antigenotoksik, antialerjik ve antienflamatuar aktiviteleriyle ve yapısında bulunan bileşiklerle insan sağlığında önemli derecede olumlu etkiye sahiptir. Bu makalede Covid-19 pandemisi dolayısıyla son günlerde daha çok popüler olmaya başlayan propolis hakkında en güncel bilgiler derlenmiştir.

Keywords

Antialerjik, Antienflamatuar, Antigenotoksik, Antikanser/Antitümör, Antimikrobiyal, Antioksidan

Supporting Institution

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Project Number

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Thanks

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Propolis

Abstract

Propolis is an important bee product. Propolis has a significant positive effect on human health with its antimicrobial, anticancer/antitumor, antioxidant, antigenotoxic, antiallergic and antiinflammatory activities and compounds found in its structure. In this review, the most up-to-date information about propolis, which has become more popular in recent days due to the Covid-19 pandemic, has been compiled.

Keywords

Antiallergic, Antiinflammatory, Antigenotoxic, Anticancer/Antitumor, Antimicrobial, Antioxidant

Project Number

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References

• Abdellatif MM, Elakkad YE, Elwakeel AA, Allam RM, ve Mousa MR (2021). Formulation and characterization of propolis and tea tree oil nanoemulsion loaded with clindamycin hydrochloride for wound healing: In-vitro and in-vivo wound healing assessment. Saudi Pharmaceutical Journal 29:1238-1249.
• Acun S, ve Gül H (2020). Fonksiyonel bir ürün olan propolisin sağlık üzerine etkisi. Uludağ Arıcılık Dergisi 20:189-208. Alakoç C (2010). Gazaltı kaynağından çıkan gazlara maruz kalan kişilerin periferal kan lenfositlerindeki mitotik indeks, replikasyon indeksi ve mikronükleus parametrelerinin değerlendirilmesi, Yozgat Bozok Üniversitesi Fen Bilimleri Enstitüsü, Yozgat.
• Albayrak S, ve Albayrak S (2008). Propolis: doğal antimikrobiyal madde. Ankara Üniversitesi Eczacılık Fakültesi Dergisi 37:201-215.
• Aldemir O, ve Memmedov H (2019). Propolisin bileşenlerinden olan kafeik asit fenil esterin antiinflamatuvar etkileri. Arıcılık Araştırma Dergisi 11:43-47.
• Almuhayawi MS (2020). Propolis as a novel antibacterial agent. Saudi journal of biological sciences 27:3079.
• Atlı Şekeroğlu Z, ve Şekeroğlu V (2011). Genetik toksisite testleri. TÜBAV Bilim Dergisi 4:221-229.
• Aydın E, Hepokur C, Mısır S, ve Yeler H (2018). Effects of propolis on oxidative stress in rabbits undergoing implant surgery. Cumhuriyet Dental Journal 21:136-144.
• Azarshinfam N, Tanomand A, Soltanzadeh H, ve Rad FA (2021). Evaluation of anticancer effects of propolis extract with or without combination with layered double hydroxide nanoparticles on Bcl-2 and Bax genes expression in HT-29 cell lines. Gene Reports 23:101031.
• Bayram S, Bayram NE, Gerçek YC, ve Sorkun K (2016). Anticytotoxic and antimutagenic effects of propolis on human lymphocytes in vitro. Mellifera 16:38-46.
• Bouchelaghem S (2021). Propolis characterization and antimicrobial activities against Staphylococcus aureus and Candida albicans: a review. Saudi journal of biological sciences.
• Bozkuş TN, Değer O, ve Yaşar A (2021). Chemical characterization of water and ethanolic extracts of turkish propolis by HPLC-DAD and GC-MS. Journal of Liquid Chromatography & Related Technologies 44:77-86.
• Campoccia D, Ravaioli S, Santi S, Mariani V, Santarcangelo C, De Filippis A, Montanaro L, Arciola CR, ve Daglia M (2021). Exploring the anticancer effects of standardized extracts of poplar-type propolis: In vitro cytotoxicity toward cancer and normal cell lines. Biomedicine & Pharmacotherapy 141:111895.
• Conte FL, Pereira AC, Brites G, Ferreira I, Silva AC, Sebastiao AI, Matos P, Pereira C, Batista MT, Sforcin JM, ve Cruz MT (2022). Exploring the antioxidant, anti-inflammatory and antiallergic potential of Brazilian propolis in monocytes. Phytomedicine Plus.
• Coşkun P, ve İnci H (2020). Propolisin kimyasal içeriği ile antibakteriyel, antiviral ve antioksidan aktivitesi. ISPEC Journal of Agricultural Sciences 4:1053-1070.
• Cui J, Duan X, Ke L, Pan X, Liu J, Song X, Ma W, Zhang W, Liu Y, ve Fan Y (2021). Extraction, purification, structural character and biological properties of propolis flavonoids: a review. Fitoterapia:105106.
• Çalışkol MM (2013). Azerbaycan yöresine ait propolis örneklerinin antioksidan özelliklerinin belirlenmesi, Karadeniz Teknik Üniversitesi Fen Bilimleri Enstitüsü, Trabzon.
• Çelemli ÖG, Temizer İK, Gölşan Z, ve Sorkun K (2016). Castanea sativa; a source of turkish propolis: plant anatomy, palynology and chemistry. Hacettepe Journal of Biology and Chemistry 44:7-14.
• Çelik B (2016). Türkiye’deki yabani Ganoderma lucidum (Curtis) P. Karst’ın genotoksik-antigenotoksik etkilerinin tavuk yumurtası mikronükleus testiyle belirlenmesi, Selçuk Üniversitesi Fen Bilimleri Enstitüsü, Konya.
• Çelik K, Demir E, Baytekin H, Yılmaz M, Kroll B, Palkova Z, Dautarte A, Slupczynska M, Kalmış H, Çelik H, Çömez Yİ, Saran MS, ve Özcan MA (2017). Apiterapi el kitabı, Ankara.
• Demir S (2010). Propolis ekstraktlarının fibroblast hücre serilerinde H2O2 İle uyarılmış DNA hasarı (genotoksisite) üzerine etkisinin comet assay yöntemi İle araştırılması, Karadeniz Teknik Üniversitesi Sağlık Bilimleri Enstitüsü, Trabzon.
• Doğan N, ve Hayoğlu İ (2012). Propolis ve kullanım alanları. Harran Tarım ve Gıda Bilimleri Dergisi 16:39-48.
• Ertürk Ö, ve Güler N (2013). Halk ilaçlarında propolisin tarihi kullanımı ile onun biyolojik aktivitesi ve kimyasal kompozisyonu. Uludağ Arıcılık Dergisi 13:33-40.
• Ghisalberti E (1979). Propolis: a review. Bee world 60:59-84.
• Gülbol Duran G (2007). In vitro koşullarda propolisin antibakteriyel, antifungal ve leyişmanyasidal etkilerinin araştırılması, Mustafa Kemal Üniversitesi Fen Bilimleri Enstitüsü, Antakya/Hatay.
• Güney F, ve Yılmaz M (2013). Propolisin kimyasal içeriği ile antibakteriyel, antiviral, antitümör, antifungal ve antioksidan aktivitesi. Arıcılık Araştırma Dergisi 10:25-28.
• Güzelmeric E, Yüksel PI, Yaman BK, Sipahi H, Çelik C, Kırmızıbekmez H, Aydın A, ve Yeşilada E (2021). Comparison of antioxidant and anti-inflammatory activity profiles of various chemically characterized Turkish propolis sub-types: which propolis type is a promising source for pharmaceutical product development? Journal of Pharmaceutical and Biomedical Analysis 203:114196.
• Hirata Y, Motoyama M, Kimura S, Takashima M, Ikawa T, Oh-Hashi K, ve Kamatari YO (2021). Artepillin C, a major component of Brazilian green propolis, inhibits endoplasmic reticulum stress and protein aggregation. European journal of pharmacology 912:174572.
• Ibrahim MEE-D, ve Alqurashi RM (2022). Anti-fungal and antioxidant properties of propolis (bee glue) extracts. International Journal of Food Microbiology 361:109463.
• Irigoiti Y, Navarro A, Yamul D, Libonatti C, Tabera A, ve Basualdo M (2021). The use of propolis as a functional food ingredient: a review. Trends in Food Science & Technology 115:297-306.
• Kashiwakura J-i, Yoshihara M, Saitoh K, Kagohashi K, Sasaki Y, Kobayashi F, Inagaki I, Kitai Y, Muromoto R, ve Matsuda T (2021). Propolis suppresses cytokine production in activated basophils and basophil-mediated skin and intestinal allergic inflammation in mice. Allergology International 70:360-367.
• Keskin M (2018). Alginat-propolis mikrokapsüllerin in vitro sindirim sisteminde salınımının ham propolis ile kıyaslanması. Uludağ Arıcılık Dergisi 18:94-100.
• Kim CH, Kim MY, Lee S-W, ve Jang K-S (2019). UPLC/FT-ICR MS-based high-resolution platform for determining the geographical origins of raw propolis samples. Journal of Analytical Science and Technology 10:1-12.
• Könen S (2007). Triflularin ve askorbik asit kombinasyonlarının oreochromis niloticus üzerindeki genotoksik ve antigenotoksik etkilerinin mikronükleus testi kullanılarak araştırılması, Mersin Üniversitesi Fen Bilimleri Enstitüsü, Mersin.
• Kuley E, Yazgan H, Özogul Y, Ucar Y, Durmus M, Özyurt G, ve Ayas D (2021). Effectiveness of Lactobacilli cell-free supernatant and propolis extract microcapsules on oxidation and microbiological growth in sardine burger. Food Bioscience 44:101417.
• Kumova U (2002). Önemli bir arı ürünü: propolis. Uludağ Arıcılık Dergisi 2:10-24.
• Laleni NC, Gomes PDC, Gkatzionis K, ve Spyropoulos F (2021). Propolis particles incorporated in aqueous formulations with enhanced antibacterial performance. Food hydrocolloids for health 1:100040.
• Liao N, Sun L, Wang D, Chen L, Wang J, Qi X, Zhang H, Tang M, Wu G, ve Chen J (2021). Antiviral properties of propolis ethanol extract against norovirus and its application in fresh juices. LWT 152:112169.
• Memmedov H, Aldemir O, ve Aliyev E (2017). Propolisin antioksidan ve antiinflamatuvar Etkisi. Arıcılık Araştırma Dergisi 9:56-62.
• Memmedov H, Aldemir O, ve Aliyev E (2018). Propolisin antikanser etkisi. Arıcılık Araştırma Dergisi 10:20-27.
• Mizuno S, Miyata R, Mukaide K, Honda S, Sukito A, Sahlan M, Taniguchi T, ve Kumazawa S (2021). New compound from the plant origin of propolis from Lombok, Indonesia and its antibacterial activity. Results in Chemistry:100276.
• Neto JC, Paulino ET, Rodrigues AKBF, da Silva JCG, Bernardino AC, dos Santos Oliveira JM, do Nascimento TG, de Souza Oliveira W, Santos JCC, ve Smaniotto S (2022). Cardioprotective effect of hydroalcoholic extract of Brazilian red propolis against isoproterenol-induced myocardial infarction in rats. Phytomedicine Plus 2:100190.
• Onur E, Gökmen GG, Nalbantsoy A, ve Kışla D (2022). Investigation of the supportive therapy potential of propolis extract and Lactobacillus acidophilus LA-5 milk combination against breast cancer in mice. Cytokine 149:155743.
• Ozkul Y, Eroglu HE, ve Ok E (2006). Genotoxic potential of Turkish propolis in peripheral blood lymphocytes. Die Pharmazie-An International Journal of Pharmaceutical Sciences 61:638-640.
• Özcan PÖ (2011). Propolisin antimutajenik etkilerinin Drosophila melanogaster'de araştırılması, Hacettepe Üniversitesi Fen Bilimleri Enstitüsü, Ankara.
• Peixoto M, Freitas AS, Cunha A, Oliveira R, ve Almeida-Aguiar C (2021). Antioxidant and antimicrobial activity of blends of propolis samples collected in different years. LWT 145:111311.
• Pereira AD, de Andrade SF, de Oliveira Swerts MS, ve Maistro EL (2008). First in vivo evaluation of the mutagenic effect of brazilian green propolis by comet assay and micronucleus test. Food and chemical toxicology 46:2580-2584.
• Pilario KE, Tielemans A, ve Mojica E-RE (2022). Geographical discrimination of propolis using dynamic time warping kernel principal components analysis. Expert Systems With Applications 187:115938.
• Rocha MP, Amorim JM, Lima WG, Brito JCM, ve da Cruz Nizer WS (2021). Effect of honey and propolis, compared to acyclovir, against Herpes Simplex Virus (HSV)-induced lesions: a systematic review and meta-analysis. Journal of Ethnopharmacology:114939.
• Rushdi AI, Adgaba N, Bayaqoob NI, Al-Khazim A, Simoneit BR, El-Mubarak AH, ve Al-Mutlaq KF (2014). Characteristics and chemical compositions of propolis from ethiopia. SpringerPlus 3:1-9.
• Salleh SNAS, Hanapiah NAM, Johari WLW, Ahmad H, ve Osman NH (2021). Analysis of bioactive compounds and chemical composition of malaysian stingless bee propolis water extracts. Saudi journal of biological sciences 28:6705-6710.
• Sameni HR, Yosefi S, Alipour M, Pakdel A, Torabizadeh N, Semnani V, ve Bandegi AR (2021). Co-administration of 5FU and propolis on AOM/DSS induced colorectal cancer in BALB-c mice. Life Sciences 276:119390.
• Sarıkahya NB, Gören AC, Okkalı GS, Çöven FO, Orman B, Kırcı D, Yücel B, Kışla D, Demirci B, ve Altun M (2021). Chemical composition and biological activities of propolis samples from different geographical regions of Turkey. Phytochemistry Letters 44:129-136.
• Seven İ, Taylan A, ve Seven PT (2007). Propolis ve hayvan beslemede kullanımı. Yüzüncü Yıl Üniversitesi Veteriner Fakültesi Dergisi 18:79-84.
• Shehata MG, Ahmad FT, Badr AN, Masry SH, ve El-Sohaimy SA (2020). Chemical analysis, antioxidant, cytotoxic and antimicrobial properties of propolis from different geographic regions. Annals of Agricultural Sciences 65:209-217.
• Silva MP, Silva TM, Mengarda AC, Salvadori MC, Teixeira FS, Alencar SM, Luz Filho GC, Bueno-Silva B, ve de Moraes J (2021). Brazilian red propolis exhibits antiparasitic properties in vitro and reduces worm burden and egg production in an mouse model harboring either early or chronic Schistosoma mansoni infection. Journal of Ethnopharmacology 264:113387.
• Silveira MAD, De Jong D, Berretta AA, dos Santos Galvão EB, Ribeiro JC, Cerqueira-Silva T, Amorim TC, da Conceição LFMR, Gomes MMD, ve Teixeira MB (2021). Efficacy of Brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: a randomized, controlled clinical trial. Biomedicine & Pharmacotherapy 138:111526.
• Song M, Wang K, Lu H, Yan S, Wu L, ve Xue X (2021). Composition and distribution of α-dicarbonyl compounds in propolis from different plant origins and extraction processing. Journal of Food Composition and Analysis 104:104141.
• Soós Á, Bódi É, Várallyay S, Molnár S, ve Kovács B (2022). Element composition of propolis tinctures prepared from hungarian raw propolis. LWT 154:112762.
• Sorucu A, ve Oruç HH (2019). Determination of biologically active phenolic compounds in propolis by LC–MS/MS according to seasons and altitudes. Journal of Food Measurement and Characterization 13:2461-2469.
• Şimşek H, Kaya E, ve Özçelik M (2017). Radyasyona maruz bırakılan ratlarda lipid peroksidasyonu ve bazı antioksidan parametreler üzerine propolisin etkisi. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 12:296-303.
• Tavares DC, Barcelos GRM, Silva LF, Tonin CCC, ve Bastos JK (2006). Propolis-induced genotoxicity and antigenotoxicity in chinese hamster ovary cells. Toxicology in vitro 20:1154-1158.
• Ünal M, Öztürk O, Selçuk MY, ve Oruç MA (2020). Propolis-literatür ne diyor? Bozok Tıp Dergisi 10:215-223. Vadillo-Rodríguez V, Cavagnola MA, Pérez-Giraldo C, ve Fernández-Calderón MC (2021). A physico-chemical study of the interaction of ethanolic extracts of propolis with bacterial cells. Colloids and Surfaces B: Biointerfaces 200:111571.
• Vică ML, Glevitzky M, Tit DM, Behl T, Heghedűş-Mîndru RC, Zaha DC, Ursu F, Popa M, Glevitzky I, ve Bungău S (2021). The antimicrobial activity of honey and propolis extracts from the central region of Romania. Food Bioscience 41:101014.
• Yıldırım Z, Hacıevliyagil S, Kutlu NO, Aydın NE, Kürkçüoğlu M, Iraz M, ve Durmaz R (2004). Effect of water extract of Turkish propolis on tuberculosis infection in guinea-pigs. Pharmacological Research 49:287-292.
• Yılmaz L, Özcan Yılsay T, ve Akpınar Bayazit A (2004). Propolisin kimyasal bileşimi, biyolojik özellikleri ve insan sağlığı üzerine etkisi. Gıda ve Yem Bilimi Teknolojisi Dergisi 6:34-38.
• Yücel B, Topal E, Akçiçek E, ve Kösoğlu M (2014). Propolisin insan sağlığına etkileri. ANADOLU Ege Tarımsal Araştırma Enstitüsü Dergisi 24:41-49.