BRUCELLOSIS in CHILDHOOD: A SINGLE CENTER EXPERIENCE

Year 2019, Volume: 13 Issue: 6, 435 - 441, 23.12.2019

Saliha Kanık Yüksek , Belgin Gülhan

https://doi.org/10.12956/tchd.506827

Cited By: 3

Abstract

Objective:
Although
brucellosis is a endemic zoonotic disease in our country, the number of
children case series related to this disease is quite low. The aim of this
study is to evaluate the cases of pediatric brucellosis in our clinic and to
contribute to the literature.

Materials
and Method: In this study, 80 pediatric patients with the
diagnosis of brucellosis follow-up by our clinic between 1 January 2009-30
September 30 2018 were conducted retrospectively. 

Results:
Of
the 80 patients, 58 (72.5%) were male and 22 (27.5%) were female and the mean
age was 11.35±3.92 (6 months-17 years). Living in a rural area was 71.3%,
 animal husbandry was 18.8%, consumption of non-pasteurized milk/dairy
products 82.5% and a family history of brucellosis was 30%. Of the patients,
65% were acute and 35% were subacute brucellosis. Brucella spp. in the blood culture was found as 17.5%, in bone
marrow culture was 6.3%, and in cerebrospinal fluid culture was 2.5%. Among the
complications, the most common was arthritis (26.3%), and less frequently
sacroiliitis (3.8%), neurobrucellosis (3.8%) and genitourinary involvement
(2.5%) were observed. Congenital brucellosis was detected in one patient,
Henoch-Schöenlein Purpura associated with brucellosis in one patient and Immun
Thrombocytopenic Purpura associated with brucellosis in two patients. 66.3% of
the cases were hospitalized. The mean hospitalization stay was 9.19 ± 8.18
(3-52) days. All patients were treated with a combined regimen. The treatment-related
side effect was 8.8%. Three patients had relapse, and no mortality was
detected.

Conclusion:
Brucellosis
continues to be a serious public health problem in our country. Although
infection is considered as a common occupational disease among adults engaged
in animal husbandry, children are at risk for this disease due to the risk of
foodborne transmission.

Keywords

Brucellosis, Child

ÇOCUKLUK ÇAĞINDA BRUSELLOZ: TEK MERKEZ DENEYİMİ

Abstract

Amaç: Bruselloz
ülkemizde endemik olarak görülen zoonotik bir hastalık olmasına rağmen bu
hastalıkla ilgili çocuk vaka serileri oldukça azdır. Bu çalışma ile kliniğimizde
takip edilen pediatrik bruselloz vakalarını değerlendirmek ve literatüre katkı
sağlamak amaçlanmıştır.

Gereç
ve Yöntemler: Bu çalışmada 1 Ocak 2009 – 30 Eylül 2018
tarihleri arasında kliniğimizde bruselloz tanısı ile takip edilen 80 çocuk
hasta retrospektif olarak incelendi.

Bulgular:
Çalışmadaki
80 hastanın 58’si (%72.5) erkek, 22’si (%27.5) kız ve yaş ortalaması 11.35±3.92
(6 ay-17 yıl) yıldı. Köy/kırsal alanda yaşama %71.3, hayvancılıkla uğraş %18.8,
pastörize edilmemiş süt/süt ürünleri tüketimi %82.5 ve ailede bruselloz öyküsü
%30 vakada tespit edildi. Hastaların %65’i akut ve %35’i subakut brusellozdu. Brucella spp. üremesi kan kültüründe
%17.5, kemik iliği kültüründe %6.3, beyin omurilik sıvısı kültüründe %2.5
oranında saptandı. Komplikasyonlar arasında en sık artrit (%26.3) daha az
sıklıkta sakroileit (%3.8), nörobruselloz (%3.8) ve genitoüriner tutulum (%2.5)
gözlendi. Bir hastada konjenital bruselloz, bir hastada bruselloz ilişkili
Henoch-Schöenlein Purpurası ve iki hastada bruselloz ilişkili İmmun
Trombositopenik Purpura tespit edildi. Vakaların %66.3’ü hospitalize edildi.
Ortalama hastaneye yatış süresi 9.19±8.18 (3-52) gün idi. Tüm hastalar kombine
rejim ile tedavi edildi. Tedavi ilişkili yan etki %8.8 oranında gözlendi. Üç hastada
relaps görülürken mortalite saptanmadı.

Sonuç: Bruselloz
ülkemizde bir halk sağlığı sorunu olarak ciddiyetini korumaya devam etmektedir. Enfeksiyon hayvancılıkla uğraşan
yetişkinler arasında yaygın bir meslek hastalığı olarak kabul edilmekle
birlikte, gıda kaynaklı bulaş riski nedeniyle çocuklar bu hastalık açısından risk
altındadır. 

Keywords

Bruselloz, Çocuk

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