Boğmaca/Boğmaca Benzeri Hastalık Nedeniyle Hastaneye Yatırılan 4 Aydan Küçük Bebeklerin Klinik Özellikleri
Abstract
Giriş ve Amaç:Bu
çalışmada 2018 yılı kış-ilkbahar-yaz döneminde boğmaca/boğmaca benzeri hastalık
ön tanısı ile yatırılarak izlenmiş hastaların klinik verilerinin sunulması
amaçlanmıştır.
Yöntem ve Gereç:
Ocak 2018-Eylül 2018 tarihleri arasında Dr. Sami Ulus Kadın-Doğum, Çocuk
Sağlığı ve Hastalıkları EAH pediatri servislerinde boğmaca, boğmaca benzeri hastalık
tanısıyla yatırılan, yaşı 4 aydan küçük olan hastalar retrospektif olarak
incelendi.
Bulgular: Toplam 97 hasta (51 erkek, 46 kız) boğmaca/boğmaca
benzeri hastalık tanısı ile izlendi. Hastaların ortanca yaşı 2 (min-maks
0,97-3.90) aydı. Vakaların hepsinde başvuru sırasında nöbetler halinde gelen
boğulur tarzda öksürük, 32 vakada (%33) akciğerde dinleme bulgusu, 5 vakada
apne, 36 vakada takipne vardı. 31
hastadan (%32) boğmaca için nazofaringeal örnekgönderildi. Gönderilen 31 örnekten
12’sinde polimeraz zincir reaksiyonu (PZR) ile B. pertussis geni pozitif olarak saptandı (%39).Yatış süresi ve
hastaların yaşı açısından boğmaca PZR pozitif, boğmaca PZR negatif ve tetkik
alınmamış grup arasında anlamlı fark yoktu. Boğmaca PZR pozitif grubunun beyaz
küresi ve lenfosit sayısı diğer iki gruba göre anlamlı olarak daha yüksekti.
Hastaların 2 tanesi ilk yatış günlerinden sonra solunum sıkıntısı nedeniyle
yoğun bakıma sevk edildi. İkisi de mekanik ventilatör desteği aldı ve şifa ile
taburcu edildi.
Tartışma ve Sonuç:
Boğmaca enfeksiyonu erken bebeklik döneminde önemli morbidite ve mortaliteye neden
olmaktadır. Maternal aşılama ve koza stratejisine yönelik kapsamlı çalışmalar
risk altındaki bu bebekleri korumada önemli katkılar sağlayabilir.
References
- Organization WHO. Global Vaccine Action Plan. Monitoring, evaluation & accountability. Secretariat annual report 2015. Geneva: World Health Organization, 2015.
- Ulloa-Gutierrez R, Boza R, Carvajal-Riggioni D, Baltodano A. Pertussis: should we improve intensive care management or vaccination strategies? Expert review of vaccines 2011;10:49-53.
- Cortese MM, Baughman AL, Zhang R, Srivastava PU, Wallace GS. Pertussis hospitalizations among infants in the United States, 1993 to 2004. Pediatrics 2008;121:484-92.
- Surridge J, Segedin ER, Grant CC. Pertussis requiring intensive care. Archives of disease in childhood 2007; 92:970-975.
- Winter K, Harriman K, Zipprich J, Schechter R, Talarico J, Walt J et al. California pertussis epidemic, 2010. The Journal of pediatrics 2012;161:1091-6.
- Cherry JD, Grimprel E, Guiso N, Heininger U, Mertsola J. Defining pertussis epidemiology: clinical, microbiologic and serologic perspectives. The Pediatric infectious disease journal 2005;24:S25-S34.
- Wood N, McIntyre P. Pertussis: review of epidemiology, diagnosis, management and prevention. Paediatric respiratory reviews. 2008;9:201-12.
- Otar G, Kılıç A, Yıldız İ, Varkal MA, Devecioğlu E. Boğmaca Enfeksiyonunun Tanı ve Tedavisi. Journal of the Child/Cocuk Dergisi. 2014;14:100-7.
- Karlı A, Şensoy G, Belet N, Yener N, Akgün M, Paksu MŞ. Boğmaca Nedeni ile Hastaneye Yatan Süt Çocuklarında Klinik Tablo ve Prognoz. Journal of Pediatric Infection/Cocuk Enfeksiyon Dergisi 2013;7:47-52.
- Törün SH, Çalişkan BB, Salman N, Öksüz L, Somer A, Gürler N. Kliniğimizde 2010 Kış-Sonbahar-Yaz Döneminde Yatırılarak İzlenmiş Boğmaca Vakalarının Sunumu. Journal of the Child/Cocuk Dergisi 2010;10:133-8.
- Long SS. Pertussis (Bordetella pertussis and Bordetella parapertussis). In: Kliegman BF, Stanton BF, St Geme JW, Schor NF (eds). Nelson Textbook Of Pediatrics 20th ed. Philadelphia, Elsevier 2016: 1377-82.
- Oikonomakou M. Exchange Transfusion: An Extra Therapeutic Tool for Severe Pertussis. EC Paediatrics 2018;7:878-83.
- Straney L, Schibler A, Ganeshalingham A, Alexander J, Festa M, Slater A et al. Burden and outcomes of severe pertussis infection in critically ill infants. Pediatric Critical Care Medicine 2016; 17:735-42.
- Goulin GD, Kaya KM, Bradley JS. Severe pulmonary hypertension associated with shock and death in infants infected with Bordetella pertussis. Critical care medicine 1993; 21:1791-4.
- Paddock CD, Sanden GN, Cherry JD, Gal AA, Langston C, Tatti KM et al. Pathology and pathogenesis of fatal Bordetella pertussis infection in infants. Clinical infectious diseases 2008; 47:328-38.
- Sawal M, Cohen M, Irazuzta JE, Kumar R, Kirton C, Brundler MA et al. Fulminant pertussis: A multi-center study with new insights into the clinico-pathological mechanisms. Pediatric pulmonology 2009;44:970-80.
- Rowlands HE, Goldman AP, Harrington K, Karimova A, Brierly J, Cross N et al. Impact of rapid leukodepletion on the outcome of severe clinical pertussis in young infants. Pediatrics 2010;126(4):e816-27
- Carrico CA, O'keefe C. Protecting infants against pertussis: The cocooning strategy in practice. The Nurse Practitioner 2013; 38:40-5.
- Terzi H, Kitiş Y. Boğmaca Bağışıklamasında Farklı Bir Yaklaşım: Koza Stratejisi. Turkiye Klinikleri Hemşirelik Bilimleri 2018;10:88-94.
- Akçaboy M, Oğuz MM, Altınel EA, Yüksel D, Şenel S, Zorlu P. Komplikasyonlarla Seyreden Bir Boğmaca Olgusu Nedeniyle “Koza Stratejisi”. Gazi Medical Journal 2017; 28:48-50.
- Skowronski DM, Janjua NZ, Tsafack EP, Ouakki M, Hoang L, De Serres G. The number needed to vaccinate to prevent infant pertussis hospitalization and death through parent cocoon immunization. Clinical Infectious Diseases 2011;54:318-27.
- Amirthalingam G, Andrews N, Campbell H, Ribeiro S, Kara E, Donegan K et al. Effectiveness of maternal pertussis vaccination in England: an observational study. The Lancet 2014;384:1521-8.
- Dabrera G, Amirthalingam G, Andrews N, Campbell H, Ribeiro S, Kara E et al. A case-control study to estimate the effectiveness of maternal pertussis vaccination in protecting newborn infants in England and Wales, 2012–2013. Clinical Infectious Diseases 2014;60:333-7.
- Westra TA, de Vries R, Tamminga JJ, Sauboin CJ, Postma MJ. Cost-effectiveness analysis of various pertussis vaccination strategies primarily aimed at protecting infants in the Netherlands. Clinical therapeutics 2010;32:1479-95.
Abstract
References
- Organization WHO. Global Vaccine Action Plan. Monitoring, evaluation & accountability. Secretariat annual report 2015. Geneva: World Health Organization, 2015.
- Ulloa-Gutierrez R, Boza R, Carvajal-Riggioni D, Baltodano A. Pertussis: should we improve intensive care management or vaccination strategies? Expert review of vaccines 2011;10:49-53.
- Cortese MM, Baughman AL, Zhang R, Srivastava PU, Wallace GS. Pertussis hospitalizations among infants in the United States, 1993 to 2004. Pediatrics 2008;121:484-92.
- Surridge J, Segedin ER, Grant CC. Pertussis requiring intensive care. Archives of disease in childhood 2007; 92:970-975.
- Winter K, Harriman K, Zipprich J, Schechter R, Talarico J, Walt J et al. California pertussis epidemic, 2010. The Journal of pediatrics 2012;161:1091-6.
- Cherry JD, Grimprel E, Guiso N, Heininger U, Mertsola J. Defining pertussis epidemiology: clinical, microbiologic and serologic perspectives. The Pediatric infectious disease journal 2005;24:S25-S34.
- Wood N, McIntyre P. Pertussis: review of epidemiology, diagnosis, management and prevention. Paediatric respiratory reviews. 2008;9:201-12.
- Otar G, Kılıç A, Yıldız İ, Varkal MA, Devecioğlu E. Boğmaca Enfeksiyonunun Tanı ve Tedavisi. Journal of the Child/Cocuk Dergisi. 2014;14:100-7.
- Karlı A, Şensoy G, Belet N, Yener N, Akgün M, Paksu MŞ. Boğmaca Nedeni ile Hastaneye Yatan Süt Çocuklarında Klinik Tablo ve Prognoz. Journal of Pediatric Infection/Cocuk Enfeksiyon Dergisi 2013;7:47-52.
- Törün SH, Çalişkan BB, Salman N, Öksüz L, Somer A, Gürler N. Kliniğimizde 2010 Kış-Sonbahar-Yaz Döneminde Yatırılarak İzlenmiş Boğmaca Vakalarının Sunumu. Journal of the Child/Cocuk Dergisi 2010;10:133-8.
- Long SS. Pertussis (Bordetella pertussis and Bordetella parapertussis). In: Kliegman BF, Stanton BF, St Geme JW, Schor NF (eds). Nelson Textbook Of Pediatrics 20th ed. Philadelphia, Elsevier 2016: 1377-82.
- Oikonomakou M. Exchange Transfusion: An Extra Therapeutic Tool for Severe Pertussis. EC Paediatrics 2018;7:878-83.
- Straney L, Schibler A, Ganeshalingham A, Alexander J, Festa M, Slater A et al. Burden and outcomes of severe pertussis infection in critically ill infants. Pediatric Critical Care Medicine 2016; 17:735-42.
- Goulin GD, Kaya KM, Bradley JS. Severe pulmonary hypertension associated with shock and death in infants infected with Bordetella pertussis. Critical care medicine 1993; 21:1791-4.
- Paddock CD, Sanden GN, Cherry JD, Gal AA, Langston C, Tatti KM et al. Pathology and pathogenesis of fatal Bordetella pertussis infection in infants. Clinical infectious diseases 2008; 47:328-38.
- Sawal M, Cohen M, Irazuzta JE, Kumar R, Kirton C, Brundler MA et al. Fulminant pertussis: A multi-center study with new insights into the clinico-pathological mechanisms. Pediatric pulmonology 2009;44:970-80.
- Rowlands HE, Goldman AP, Harrington K, Karimova A, Brierly J, Cross N et al. Impact of rapid leukodepletion on the outcome of severe clinical pertussis in young infants. Pediatrics 2010;126(4):e816-27
- Carrico CA, O'keefe C. Protecting infants against pertussis: The cocooning strategy in practice. The Nurse Practitioner 2013; 38:40-5.
- Terzi H, Kitiş Y. Boğmaca Bağışıklamasında Farklı Bir Yaklaşım: Koza Stratejisi. Turkiye Klinikleri Hemşirelik Bilimleri 2018;10:88-94.
- Akçaboy M, Oğuz MM, Altınel EA, Yüksel D, Şenel S, Zorlu P. Komplikasyonlarla Seyreden Bir Boğmaca Olgusu Nedeniyle “Koza Stratejisi”. Gazi Medical Journal 2017; 28:48-50.
- Skowronski DM, Janjua NZ, Tsafack EP, Ouakki M, Hoang L, De Serres G. The number needed to vaccinate to prevent infant pertussis hospitalization and death through parent cocoon immunization. Clinical Infectious Diseases 2011;54:318-27.
- Amirthalingam G, Andrews N, Campbell H, Ribeiro S, Kara E, Donegan K et al. Effectiveness of maternal pertussis vaccination in England: an observational study. The Lancet 2014;384:1521-8.
- Dabrera G, Amirthalingam G, Andrews N, Campbell H, Ribeiro S, Kara E et al. A case-control study to estimate the effectiveness of maternal pertussis vaccination in protecting newborn infants in England and Wales, 2012–2013. Clinical Infectious Diseases 2014;60:333-7.
- Westra TA, de Vries R, Tamminga JJ, Sauboin CJ, Postma MJ. Cost-effectiveness analysis of various pertussis vaccination strategies primarily aimed at protecting infants in the Netherlands. Clinical therapeutics 2010;32:1479-95.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Internal Diseases |
| Journal Section | ORIGINAL ARTICLES |
| Authors | |
| Publication Date | January 22, 2021 |
| Submission Date | July 7, 2019 |
| Published in Issue | Year 2021 Volume: 15 Issue: 1 |
The publication language of Turkish Journal of Pediatric Disease is English.
Manuscripts submitted to the Turkish Journal of Pediatric Disease will go through a double-blind peer-review process. Each submission will be reviewed by at least two external, independent peer reviewers who are experts in the field, in order to ensure an unbiased evaluation process. The editorial board will invite an external and independent editor to manage the evaluation processes of manuscripts submitted by editors or by the editorial board members of the journal. The Editor in Chief is the final authority in the decision-making process for all submissions. Articles accepted for publication in the Turkish Journal of Pediatrics are put in the order of publication, with at least 10 original articles in each issue, taking into account the acceptance dates. If the articles sent to the reviewers for evaluation are assessed as a senior for publication by the reviewers, the section editor and the editor considering all aspects (originality, high scientific quality and citation potential), it receives publication priority in addition to the articles assigned for the next issue.
The aim of the Turkish Journal of Pediatrics is to publish high-quality original research articles that will contribute to the international literature in the field of general pediatric health and diseases and its sub-branches. It also publishes editorial opinions, letters to the editor, reviews, case reports, book reviews, comments on previously published articles, meeting and conference proceedings, announcements, and biography. In addition to the field of child health and diseases, the journal also includes articles prepared in fields such as surgery, dentistry, public health, nutrition and dietetics, social services, human genetics, basic sciences, psychology, psychiatry, educational sciences, sociology and nursing, provided that they are related to this field. can be published.