Evaluation of Etiological Factors Causing Hypereosinophilia in Children

Year 2021, Volume: 15 Issue: 5, 373 - 378, 23.09.2021

İlknur Külhaş Çelik , Betül Büyüktiryaki , Filiz Gültekin Açıkgöz Mehmet Orhan Erkan , Zeliha Guzelkucuk , Namık Yaşar Özbek , Muge Toyran , Emine Dibek Mısırlıoğlu , Ersoy Civelek

https://doi.org/10.12956/tchd.933050

Cited By: 1

Abstract

Objective: Patients with persistent eosinophilia may have many conditions ranging from relatively benign diseases such as parasitic serious infections to life-threatening serious diseases. We aimed to determine the etiological causes of hypereosinophilia in children. 

Material and Methods: Patients under 18 years of age who had complete blood counts in Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital’s pediatric clinics between January 2013-January 2016 were retrospectively analyzed. Hypereosinophilia was defined as having at least two peripheral blood absolute eosinophil counts greater than or equal to 1500/mm3.The results of the examinations and diagnoses when the patients were detected with hypereosinophilia were recorded from the hospital records.

Results: Three hundred and forty patients who underwent complete blood count were found to have hypereosinophilia. Seventy patients whose file records could not be accessed were excluded from the study. Two-hundred seventy patients (56% male) with a median age of 5 (IQR:1-12) years were included in our study. When the diagnoses of patients were examined, 48 (17.8%) had allergic diseases, 21 (7.8%) had immunodeficiency, 14 (5.2%) had parasitic disease. 15 (5.5%) had tumor, 4 (1.5%) had leukemia, 2 (0.7%) had hypereosinophilic syndrome, 2 (0.7%) had adrenal insufficiency and 2 (0.7%) had burn. Ninety-nine (36.7%) patients were found to use medication for any disease (acute or chronic). As a result of the
examinations performed in 63 (23.3%) patients, it was found that there was no reason to explain hypereosinophilia.

Conclusion: The number of eosinophils may increase in many conditions. The cause of increase in eosinophil may not always be found.
Further studies are needed on the long-term prognosis of these patients.

Keywords

hypereosinophilia, childhood, parasitic infections, allergic diseases, immunologic diseases

Çocuklarda Hipereozinofiliye Neden Olan Etiyolojik Faktörlerin Değerlendirilmesi

Abstract

Amaç: Hipereozinofili hastaları, paraziter enfeksiyonlar gibi nispeten iyi huylu hastalıklardan yaşamı tehdit eden ciddi hastalıklara kadar pek
çok duruma sahip olabilir. Çalışmamızda çocuklarda hipereozinofilinin etiyolojik nedenlerinin belirlenmesi amaçlanmıştır.

Gereç ve Yöntemler: Ankara Çocuk Sağlığı ve Hastalıkları Hematoloji Onkoloji Eğitim ve Araştırma Hastanesi pediatri kliniklerinde Ocak
2013 - Ocak 2016 tarihleri arasında tam kan sayımı yapılan 18 yaş altı hastalar retrospektif olarak incelendi.
En az iki tam kan sayımı ölçümünde periferik kan mutlak eozinofil sayısının 1500/mm3 veya daha büyük olması hipereozinofili olaral kabul
edildi. Hastane kayıtlarından hipereozinofili tespit edildiğinde yapılan tetkik ve tanıların sonuçları kaydedildi.

Bulgular: Tam kan sayımı yapılan çocuk hastaların 340’ında hipereozinofili olduğu tespit edildi. Dosya kayıtlarına ulaşılamayan 70 hasta
çalışma dışı bırakıldı. Çalışmamıza, yaşları ortanca 5 (1-12) [ortanca (çeyrekler arası aralık (ÇAA)] yıl olan 270 (%56’sı erkek) hasta dahil
edildi. Hastalara konulan tanılar incelendiğinde: 48’ine (%17.8) alerjik hastalık, 21’ine (%7.8) immün yetmezlik, 14’üne (%5.2) paraziter
hastalık, 15’ine tümör (%5.6), 4’üne (%1.5) lösemi, 2’sine (%0.7) hipereozinofilik sendrom, 2’sine (%0.7) adrenal yetmezlik, 2’sine (%0.7)
yanık tanısı konulduğu tespit edildi. Doksan dokuz (%36.7) hastada ise herhangi bir hastalık için (akut veya kronik) ilaç kullanımı (antibiyotik,
antiepileptik, demir şelatörü gibi) olduğu tespit edildi. Altmış üç (%23.3) hastada ise yapılan tetkikler sonucunda hipereozinofiliyi açıklayacak
bir neden bulunamadığı görüldü.

Sonuç: Kanda eozinofil sayısı pek çok durumda da yükselebilir. Eozinofil yüksekliğinin sebebi her zaman bulunamayabilir. Bu hastaların
uzun dönem prognozları hakkında yapılacak ileri çalışmalara ihtiyaç vardır.

Keywords

çocukluk çağı, hipereozinofili, alerjik hastalıklar, immünolojik hastalıklar, paraziter enfeksiyonlar

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