Ursodeoksikolik Asit’in Farelerde Pentilentetrazol ile Oluşturulan Akut Epileptik Nöbetler Üzerine Etkisinin Araştırılması

Year 2020, , 170 - 174, 30.12.2020

Sebahattin Karabulut , Ahmet Şevki Taşkıran

https://doi.org/10.46810/tdfd.761990

Abstract

Öz: Bu çalışmanın amacı, Ursodeksikolik asit (UDKA) ön tedavisinin PTZ ile indüklenen akut epilepsi fare modelinde nöbet davranışına ve hipokampal total oksidan status (TOS) ve kaspaz-3 ekpresyonlarına etkisini araştırmaktır. Çalışmada BALB-c türü 24 hayvan rastgele 4 gruba ayrıldı: Kontrol grubu, PTZ; PTZ ile nöbet indüklenen grup, UDKA-100; 5 gün boyunca UDKA 100 mg kg-1 verilen ve PTZ uygulanan grup, UDKA-200; 5 gün boyunca UDKA 200 mg kg-1 verilen ve PTZ uygulanan grup. UDKA ön tedavisinin nöbet davranışı üzerine istatistiksel olarak anlamlı bir etkisi bulunmadı. UDKA-200 grubunda daha belirgin olmak üzere, UDKA ön tedavisi hipokampal TOS ekspresyonunu anlamlı olarak azalttı. Benzer şekilde, hipokampal kaspaz-3 ekspresyonu UDKA alan gruplarda daha düşük bulundu. Sonuç olarak, UDKA antioksidatif ve antiapoptotik özellikleriyle epilepsi tedavisi için faydalı bir terapotik ajan olabilir.

Keywords

Ursodeoksikolik asit, PTZ, Nöbet, Oksidatif Stres

Supporting Institution

Herhangi bir kurumdan destek alınmamıştır.

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