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mRNA SARS-CoV2 Specific and Childhood Vaccines against Covid-19 Pandemic

Year 2021, Volume: 10 Issue: 2, 338 - 350, 31.12.2021

İdris Yazgan

https://doi.org/10.46810/tdfd.994622

Abstract

The coronavirus disease 2019 (Covid-19) pandemic has been challenging the entire world since early 2020. Due to the fact that there is no universally available treatment method along with the disease’s fast transmission from human to human, specific vaccine development efforts have got a great attention. Particularly mRNA-based severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) specific vaccines are administrated to individuals worldwide to combat against Covid-19 infection. Even though two dose mRNA vaccination provides immunity against ancestral and aggressive variants of SARS-CoV2 infections, rare detrimental short-time side effects and no-data availability on long-term possible side-effects along with unpredictable vaccination regime bring hesitancy against the vaccines. Besides, the vaccination regime is still under debate among the scientist as that whether pre-infected individuals require further vaccination and what should be the ideal vaccination dose. In addition to mRNA SARS-CoV2 specific vaccines, recent retrospective, theoretical, clinical, and biochemical studies revealed that trained innate immunity and heterologous T-cells and memory B-cells can be strong alternative to combat against SARS-CoV2 pandemic. In this context, conventional childhood vaccines (e.g., BCG and MMR) are proposed as valuable alternative vaccines against the pandemic with known clinical outcomes and effectivity.

Keywords

SARS-CoV2 mRNA vaccines conventional vaccines immunity

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Covid-19’a karşı mRNA SARS-CoV2 spesifik ve Çocukluk Dönemi Aşıları

Year 2021, Volume: 10 Issue: 2, 338 - 350, 31.12.2021

İdris Yazgan

https://doi.org/10.46810/tdfd.994622

Abstract

2019 yılı koronavirus hastalığı (Covid-19) pandemisi 2020 yılından beri dünya çapında bir sorun haline gelmiştir. Evrensel olarak kabul edilmiş bir tedavisinin olmayışı ve insandan-insana geçişinin hızlı olması nedeniyle spesifik aşı geliştirme çalışmaları önem kazanmıştır. mRNA-temelli ağır akut solunum yolu yetersizliği sendromu korovirus 2 (SARS-CoV2) aşıları dünya çapında Covid-19’un kontrol altına alınmasına yönelik olarak en yaygın olarak kullanılan aşılardır. Herne kadar iki doz mRNA aşılarının hem atasal hemde mutasyona uğramış agresif SARS-CoV2 viral enfeksiyonlarına karşı yüksek bağışıklık sağlıyor olmalarına karşın, nadir olarak görülen kısa dönem yan etkileri ve uzun dönemli olası yan etkileri hakkında bilgilerin mevcut olmaması nedeniyle aşılara karşı bir tereddüt mevcuttur. Buna ek olarak, aşılama rejimin nasıl olması gerektiği bilimadaları arasında hala tartışma konusudur, örneğin enfeksiyon geçirmiş olan bireyler tekrar aşı olmalı mı ve kaç doz aşı olunması gerekir. mRNA temelli SARS-CoV2 aşılarına alternatif olarak, yeni yapılan retrospektif, teorik, klinik ve biyokimyasal çalışmalar, eğitilmiş doğal bağışıklığın ve heterelog T-hücrelerinin ve hafıza B hücrelerinin SARS-CoV2 pandemisine karşı savaşta önemli bir alternatif olabileceği önerilmiştir. Bu kapsamda, klasik çocukluk dönemi aşılarının (örneğin BCG ve MMR) pandemiye karşı bilinen klinik souçları ve etkinliği nedeniyle önemli alternatif aşılar oldukları görülmektedir.

Keywords

SARS-CoV2 mRNA vaccines conventional vaccines immunity

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Primary Language English
Subjects Engineering
Journal Section Articles
Authors

İdris Yazgan 0000-0002-0264-1253

Publication Date December 31, 2021
Published in Issue Year 2021 Volume: 10 Issue: 2

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APA Yazgan, İ. (2021). mRNA SARS-CoV2 Specific and Childhood Vaccines against Covid-19 Pandemic. Türk Doğa Ve Fen Dergisi, 10(2), 338-350. https://doi.org/10.46810/tdfd.994622
AMA Yazgan İ. mRNA SARS-CoV2 Specific and Childhood Vaccines against Covid-19 Pandemic. TJNS. December 2021;10(2):338-350. doi:10.46810/tdfd.994622
Chicago Yazgan, İdris. “MRNA SARS-CoV2 Specific and Childhood Vaccines Against Covid-19 Pandemic”. Türk Doğa Ve Fen Dergisi 10, no. 2 (December 2021): 338-50. https://doi.org/10.46810/tdfd.994622.
EndNote Yazgan İ (December 1, 2021) mRNA SARS-CoV2 Specific and Childhood Vaccines against Covid-19 Pandemic. Türk Doğa ve Fen Dergisi 10 2 338–350.
IEEE İ. Yazgan, “mRNA SARS-CoV2 Specific and Childhood Vaccines against Covid-19 Pandemic”, TJNS, vol. 10, no. 2, pp. 338–350, 2021, doi: 10.46810/tdfd.994622.
ISNAD Yazgan, İdris. “MRNA SARS-CoV2 Specific and Childhood Vaccines Against Covid-19 Pandemic”. Türk Doğa ve Fen Dergisi 10/2 (December 2021), 338-350. https://doi.org/10.46810/tdfd.994622.
JAMA Yazgan İ. mRNA SARS-CoV2 Specific and Childhood Vaccines against Covid-19 Pandemic. TJNS. 2021;10:338–350.
MLA Yazgan, İdris. “MRNA SARS-CoV2 Specific and Childhood Vaccines Against Covid-19 Pandemic”. Türk Doğa Ve Fen Dergisi, vol. 10, no. 2, 2021, pp. 338-50, doi:10.46810/tdfd.994622.
Vancouver Yazgan İ. mRNA SARS-CoV2 Specific and Childhood Vaccines against Covid-19 Pandemic. TJNS. 2021;10(2):338-50.
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