Morphological and Mechanical Assessment of Electrospun PLGA Vascular Scaffolds

Year 2024, Volume: 34 Issue: 3, 222 - 230, 30.09.2024

Suzan Özdemir , Janset Öztemur , Hande Sezgin , İpek Yalcin Enis

https://doi.org/10.32710/tekstilvekonfeksiyon.1284898

Abstract

Cardiovascular disorders are the leading cause of global mortality and typically necessitate bypass surgery to replace the damaged blood vessel. Currently used grafts are insufficient to replace small-diameter blood vessels due to the scarcity and harsh harvesting procedure of autologous vessels and the shortcomings in the clinical performance of synthetic grafts, which might result in intimal hyperplasia, thrombosis, and compliance mismatch. Therefore, there is a critical need for tissue-engineered vascular grafts that can meet morphological, mechanical, and biological characteristics. In this study, poly(lactic-co-glycolic acid) tubular scaffolds with randomly distributed or radially oriented fibers were produced by electrospinning, and the effect of fiber orientation on morphological and mechanical properties was investigated. The findings demonstrate that, while the successful implementation of radial fiber orientation with high rotational speed production enhanced burst strength and radial tensile strength values, it was unfavorable for compliance.

Keywords

Tissue engineering, Vascular grafts, Compliance mismatch, PLGA

Supporting Institution

TUBITAK , ITU

Project Number

121M309 (TUBITAK), 43368 (ITU-BAP), 44230 (ITU-GAP)

Thanks

This study is supported by TUBITAK Project under grant no. 121M309, ITU Scientific Research Project under grant no. 43368, and ITU General Research Project under grant no. 44230.

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