EVALUATION OF INSULIN RESISTANCE IN PATIENTS WITH PREMATURE ADRENARCHE

Year 2023, Volume: 4 Issue: 1, 1 - 6, 31.01.2023

Nurullah Çelik , Gülşah Ünsal

https://doi.org/10.51972/tfsd.1144735

Abstract

Purpose: There is a conflicting result in terms of insulin resistance (IR) in children with Premature Adrenarche (PA). The study aimed to investigate the IR and Trıglycerıde-Glucose (Ty-G) index in patıents wıth PA.

Material and Methods: This cross-sectional study was conducted in a tertiary pediatric endocrinology clinic with 160 children aged 6-8 years old. The study group (n=75) were selected cases diagnosed with PA. Seventy-nine age and sex-matched children were also selected as a control group. Ty-G İndex, Homeostasis Model of Insulin Resistance (HOMA-IR), and atherogenic index of plasma (AIP) were calculated.

Results: Trıglycerıde-Glucose index, AIP, and HOMA-IR were similar (p>0.05). Ty-G İndex was positively correlated with AIP (r=0.61, p<0.001), BMI-SDS (r=0.26, p=0.002), and HOMA-IR (r=0.33, p<0.001) levels. The DHEA-S level was correlated with the AIP (r=0.24, p=0.005), and BMI-SDS (r=0.17, p=0.03) levels. BMI-SDS was correlated wtih HOMA-IR (r=0.28, p=0.02) levels.

Conclusion: Non-obese children with PA have similar IR parameters compared with control groups. Therefore, additional evaluation for IR parameters in lean children with PA is not required.

Keywords

Premature Adrenarche, Insulin Resistance, Triglyceride Glucose index, Homeostasis Model of Insulin Resistance, Plasma atherogenic index

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