Abstract
Amaç: Bu çalışmada kalp-akciğer makinesi kullanılarak yapılan ameliyatlarda kardiyopulmoner baypas (KPB)'nin beta-2 mikroglobulin (β2M) kan plazma düzeyini etkileyip etkilemediğinin ve prognoza etkisinin araştırılması amaçlanmıştır.
Gereç ve Yöntemler: Çalışma, Sivas Cumhuriyet Üniversitesi Kalp ve Damar Cerrahisi Anabilim Dalı'nda kalp-akciğer makinesi kullanılarak kalp ameliyatı yapılan 33 hasta üzerinde gerçekleştirildi. Ameliyattan hemen önce, kalp-akciğer makinesine bağlandıktan 30 dakika sonra ve ameliyat sonrası 24. saatte alınan periferik venöz kan örneklerinde plazma β2M düzeyleri değerlendirildi.
Bulgular: Yüksek β2M düzeyinin uzun yoğun bakım ve hastanede kalış süresi, uzamış entübasyon, artmış inotrop gereksinimi ve kan ürünü kullanımı ile ilişkili olduğu görüldü (P<.001). Ek olarak; ileri yaş, tütün kullanımı, hiperlipidemi ve hipertansiyon da yüksek β2M seviyeleri ile ilişkiliydi (P<.001). Kalp-akciğer makinesinin plazma β2M düzeyini etkilemediği görüldü (P=0,843).
Sonuç: Kalp-akciğer makinesi plazma β2M düzeylerini etkilemedi. Bununla birlikte, yüksek β2M düzeylerinin açık kalp cerrahisinde kötü prognoz için öngörücü bir belirteç olarak kullanılabileceği muhtemel görünmektedir.
Keywords
Beta-2 mikroglobulin, Kalp cerrahisi, Kardiyopulmoner by-pass makinesi, Açık kalp cerrahisi
Supporting Institution
yok
Project Number
yok
Thanks
Biyokimya anabilim dalı öğretim üyesi Doç. Dr. Halef Okan Doğan'a materyallerin saklanmasındaki işbirliği için teşekkür ederiz
References
- REFERENCES
- Referans1 Amighi, J., Hoke, M., Mlekusch, W. et al. (2011). Beta 2 Microglobulin and the Risk for Cardiovascular Events in Patients With Asymptomatic Carotid Atherosclerosis. Stroke, 42(7), 1826-1833. doi:doi:10.1161/STROKEAHA.110.600312
- Referans2 Bethea, M., and Forman, D. (1990). Beta 2-microglobulin: its significance and clinical usefulness. Annals of Clinical & Laboratory Science, 20(3), 163-168.
- Referans3 BMY, C., FCC, T., CL, C. et al. (2016). GW27-e0922 Beta-2 microglobulin level in serum is elevated in patients presenting with acute coronary syndrome. Journal of the American College of Cardiology, 68(16_Supplement), C97-C97. doi:doi:10.1016/j.jacc.2016.07.363
- Referans4 Cheung, B., Tam, F., Cheung, C. et al. (2017). Serum Beta-2 Microglobulin Level is Elevated in Patients with Acute Coronary Syndrome. Clinical Therapeutics, 39(8), e52.
- Referans5 Çalışal, M. A. (2013). The effects of single and dual reservoired oxygenators on inflammatory response in cardiopulmonary bypass. Turkish Journal of Thoracic and Cardiovascular Surgery, 21(2).
- Referans6 Huang, Y., Lin, Y., Zhai, X. et al. (2022). Association of Beta-2-Microglobulin With Coronary Heart Disease and All-Cause Mortality in the United States General Population. Front Cardiovasc Med, 9, 834150. doi:10.3389/fcvm.2022.834150
- Referans7 Johnson Jr, H., Flye, M. W., and Javadpour, N. (1980). Serum β2 microglobulin levels in patients with testicular cancer. Urology, 16(5), 522-524.
- Referans8 J.E. Ho, A. Lyass, P. Courchesne, et al., (2018). Protein biomarkers of cardiovascular disease and mortality in the community, J. Am. Heart Assoc. 7 (14) e008108, https://doi.org/10.1161/JAHA.117.008108.
- Referans9 Liabeuf, S., Lenglet, A., Desjardins, L. et al. (2012). Plasma beta-2 microglobulin is associated with cardiovascular disease in uremic patients. Kidney International, 82(12), 1297-1303. doi:https://doi.org/10.1038/ki.2012.301
- Referans10 M. Matsui, K. Samejima, Y. Takeda, et al., (2016). Angiogenic factors and risks of technique failure and cardiovascular events in patients receiving peritoneal dialysis, Cardiorenal Med. 6 (3) 251–259, https://doi.org/10.1159/000444886.
- Referans11 Möckel, M., Muller, R., Searle, J. et al. (2015). Usefulness of Beta2-Microglobulin as a Predictor of All-Cause and Nonculprit Lesion-Related Cardiovascular Events in Acute Coronary Syndromes (from the PROSPECT Study). The American Journal of Cardiology, 116(7), 1034-1040. doi:https://doi.org/10.1016/j.amjcard.2015.07.017
- Referans12 Nead, K. T., Zhou, M. J., Caceres, R. D. et al. (2013). Usefulness of the Addition of Beta-2-Microglobulin, Cystatin C and C-Reactive Protein to an Established Risk Factors Model to Improve Mortality Risk Prediction in Patients Undergoing Coronary Angiography. The American Journal of Cardiology, 111(6), 851-856. doi:https://doi.org/10.1016/j.amjcard.2012.11.055
- Referans13 Abacıoğlu, Ö., and Kaplan, M. (2020). Beta 2 microglobulin levels are higher in Coronary Slow Flow Phenomenon. Acta Medica Alanya, 4(2), 144-149.
- Referans14 R.L. Prentice, S. Zhao, M. Johnson, et al., (2013). Proteomic risk markers for coronary heart disease and stroke: validation and mediation of randomized trial hormone therapy effects on these diseases, Genome Med. 5 (12) 112, https://doi.org/ 10.1186/gm517.
- Referans15 Shi, F., Sun, L., and Kaptoge, S. (2021). Association of beta-2-microglobulin and cardiovascular events and mortality: A systematic review and meta-analysis. Atherosclerosis, 320, 70-78. doi:https://doi.org/10.1016/j.atherosclerosis.2021.01.018
- Referans16 Tomlinson, P. A. (1992). Low molecular weight proteins in children with renal disease. Pediatr Nephrol, 6(6), 565-571. doi:10.1007/bf00866510
- Referans17 Wang, H. J., Si, Q. J., Shi, Y. et al. (2018). The prognostic values of beta-2 microglobulin for risks of cardiovascular events and mortality in the elderly patients with isolated systolic hypertension. J Res Med Sci, 23, 82. doi:10.4103/jrms.JRMS_135_17
- Referans18 Wong, E. (1999). Clinical Laboratory Diagnostics: Use and Assessment of Clinical Laboratory Results. Lothar Thomas. Frankfurt/Main, Germany: TH-Books Verlagsgeselschaft, 1998, 1727 pp., $149.00. ISBN 3-9805215-4-0. Clinical Chemistry, 45(4), 586-587. doi:10.1093/clinchem/45.4.586a
- Referans19 You, L., Xie, R., Hu, H. et al. (2017). High levels of serum β2-microglobulin predict severity of coronary artery disease. BMC Cardiovascular Disorders, 17(1), 71. doi:10.1186/s12872-017-0502-9
- Referans20 Zhang, C., Li, F., Long, T. et al. (2019). Beta 2-Microglobulin and the Severity of Coronary Stenosis in Patients With Acute Coronary Syndrome. Heart, Lung and Circulation, 28(4), 575-582. doi:https://doi.org/10.1016/j.hlc.2018.02.016
Abstract
Purpose: In this study, it was aimed to investigate whether beta-2 microglobulin (β2M) blood plasma level is affected by cardiopulmonary bypass (CPB) and its effects on prognosis in surgeries performed using a heart-lung machine.
Material and Methods: The study was carried out on 33 patients who underwent cardiac surgery using a heart-lung machine in the cardiovascular surgery department of Sivas Cumhuriyet University. Plasma β2M levels were evaluated in peripheral venous blood samples taken just before the operation, thirty minutes after connecting to the heart-lung machine, and at the twenty-fourth postoperative hour.
Results: It was observed that a high β2M level was associated with long intensive care and hospital stay, prolonged intubation, increased inotrope requirement, and blood product use (P<.001). In addition; advanced age, tobacco use, hyperlipidemia, and hypertension were also associated with high β2M levels (P<.001). It was observed that the heart-lung machine did not affect the plasma β2M level (P=0.843).
Conclusion: The heart-lung machine did not affect the plasma β2M levels. However, it seems likely that high β2M levels can be used as a predictive marker for poor prognosis in open heart surgery.
Keywords: Beta-2 microglobulin, Cardiac surgery, Cardiopulmonary bypass machine, Open heart surgery
Project Number
yok
References
- REFERENCES
- Referans1 Amighi, J., Hoke, M., Mlekusch, W. et al. (2011). Beta 2 Microglobulin and the Risk for Cardiovascular Events in Patients With Asymptomatic Carotid Atherosclerosis. Stroke, 42(7), 1826-1833. doi:doi:10.1161/STROKEAHA.110.600312
- Referans2 Bethea, M., and Forman, D. (1990). Beta 2-microglobulin: its significance and clinical usefulness. Annals of Clinical & Laboratory Science, 20(3), 163-168.
- Referans3 BMY, C., FCC, T., CL, C. et al. (2016). GW27-e0922 Beta-2 microglobulin level in serum is elevated in patients presenting with acute coronary syndrome. Journal of the American College of Cardiology, 68(16_Supplement), C97-C97. doi:doi:10.1016/j.jacc.2016.07.363
- Referans4 Cheung, B., Tam, F., Cheung, C. et al. (2017). Serum Beta-2 Microglobulin Level is Elevated in Patients with Acute Coronary Syndrome. Clinical Therapeutics, 39(8), e52.
- Referans5 Çalışal, M. A. (2013). The effects of single and dual reservoired oxygenators on inflammatory response in cardiopulmonary bypass. Turkish Journal of Thoracic and Cardiovascular Surgery, 21(2).
- Referans6 Huang, Y., Lin, Y., Zhai, X. et al. (2022). Association of Beta-2-Microglobulin With Coronary Heart Disease and All-Cause Mortality in the United States General Population. Front Cardiovasc Med, 9, 834150. doi:10.3389/fcvm.2022.834150
- Referans7 Johnson Jr, H., Flye, M. W., and Javadpour, N. (1980). Serum β2 microglobulin levels in patients with testicular cancer. Urology, 16(5), 522-524.
- Referans8 J.E. Ho, A. Lyass, P. Courchesne, et al., (2018). Protein biomarkers of cardiovascular disease and mortality in the community, J. Am. Heart Assoc. 7 (14) e008108, https://doi.org/10.1161/JAHA.117.008108.
- Referans9 Liabeuf, S., Lenglet, A., Desjardins, L. et al. (2012). Plasma beta-2 microglobulin is associated with cardiovascular disease in uremic patients. Kidney International, 82(12), 1297-1303. doi:https://doi.org/10.1038/ki.2012.301
- Referans10 M. Matsui, K. Samejima, Y. Takeda, et al., (2016). Angiogenic factors and risks of technique failure and cardiovascular events in patients receiving peritoneal dialysis, Cardiorenal Med. 6 (3) 251–259, https://doi.org/10.1159/000444886.
- Referans11 Möckel, M., Muller, R., Searle, J. et al. (2015). Usefulness of Beta2-Microglobulin as a Predictor of All-Cause and Nonculprit Lesion-Related Cardiovascular Events in Acute Coronary Syndromes (from the PROSPECT Study). The American Journal of Cardiology, 116(7), 1034-1040. doi:https://doi.org/10.1016/j.amjcard.2015.07.017
- Referans12 Nead, K. T., Zhou, M. J., Caceres, R. D. et al. (2013). Usefulness of the Addition of Beta-2-Microglobulin, Cystatin C and C-Reactive Protein to an Established Risk Factors Model to Improve Mortality Risk Prediction in Patients Undergoing Coronary Angiography. The American Journal of Cardiology, 111(6), 851-856. doi:https://doi.org/10.1016/j.amjcard.2012.11.055
- Referans13 Abacıoğlu, Ö., and Kaplan, M. (2020). Beta 2 microglobulin levels are higher in Coronary Slow Flow Phenomenon. Acta Medica Alanya, 4(2), 144-149.
- Referans14 R.L. Prentice, S. Zhao, M. Johnson, et al., (2013). Proteomic risk markers for coronary heart disease and stroke: validation and mediation of randomized trial hormone therapy effects on these diseases, Genome Med. 5 (12) 112, https://doi.org/ 10.1186/gm517.
- Referans15 Shi, F., Sun, L., and Kaptoge, S. (2021). Association of beta-2-microglobulin and cardiovascular events and mortality: A systematic review and meta-analysis. Atherosclerosis, 320, 70-78. doi:https://doi.org/10.1016/j.atherosclerosis.2021.01.018
- Referans16 Tomlinson, P. A. (1992). Low molecular weight proteins in children with renal disease. Pediatr Nephrol, 6(6), 565-571. doi:10.1007/bf00866510
- Referans17 Wang, H. J., Si, Q. J., Shi, Y. et al. (2018). The prognostic values of beta-2 microglobulin for risks of cardiovascular events and mortality in the elderly patients with isolated systolic hypertension. J Res Med Sci, 23, 82. doi:10.4103/jrms.JRMS_135_17
- Referans18 Wong, E. (1999). Clinical Laboratory Diagnostics: Use and Assessment of Clinical Laboratory Results. Lothar Thomas. Frankfurt/Main, Germany: TH-Books Verlagsgeselschaft, 1998, 1727 pp., $149.00. ISBN 3-9805215-4-0. Clinical Chemistry, 45(4), 586-587. doi:10.1093/clinchem/45.4.586a
- Referans19 You, L., Xie, R., Hu, H. et al. (2017). High levels of serum β2-microglobulin predict severity of coronary artery disease. BMC Cardiovascular Disorders, 17(1), 71. doi:10.1186/s12872-017-0502-9
- Referans20 Zhang, C., Li, F., Long, T. et al. (2019). Beta 2-Microglobulin and the Severity of Coronary Stenosis in Patients With Acute Coronary Syndrome. Heart, Lung and Circulation, 28(4), 575-582. doi:https://doi.org/10.1016/j.hlc.2018.02.016
Details
| Primary Language | English |
|---|---|
| Subjects | Primary Health Care |
| Journal Section | Articles |
| Authors | |
| Project Number | yok |
| Publication Date | January 31, 2023 |
| Submission Date | January 21, 2023 |
| Acceptance Date | January 28, 2023 |
| Published in Issue | Year 2023 Volume: 4 Issue: 1 |
Turkish Journal of Science and Health (TFSD)
E-mail: tfsdjournal@gmail.com
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