Purpose: The purpose of our research is to determine the protective impact of CoronaVac vaccine in individuals under the age of 40 and over the age of 18 who have had COVID-19 infection.
Material and Methods: Patients aged 18-40 years who applied to our hospital with COVID-19 + as a test were divided into two groups according to their coronaVac vaccine status, and the morbidity and mortality of the patients were investigated.
Results: In the present research, the total mortality ratio in the unvaccinated patient group was 8.2%, while the overall mortality rate in the patient group vaccinated was 0% (p = .043).
Conclusion: The 0% mortality rate in persons who received two doses of CoronaVac vaccine clearly shows the effect of the vaccine on mortality.
Amato, M. K., Hennessy, C., Shah, K., Mayer, J. (2021).Multisystem Inflammatory Syndrome in an Adult. The
Journal of emergency medicine, 61(1), 1–3. https://doi.org/10.1016/j.jemermed.2021.02.007
Chaimayo, C., Kaewnaphan, B., Tanlieng, N., Athipanyasilp, N., Sirijatuphat, R., Chayakulkeeree, M.,
Angkasekwinai, N., Sutthent, R., Puangpunngam, N.,Tharmviboonsri, T., Pongraweewan, O., Chuthapisith,
S., Sirivatanauksorn, Y., Kantakamalakul, W.,Horthongkham, N. (2020). Rapid SARS-CoV-2 antigen
detection assay in comparison with real-time RT-PCRassay for laboratory diagnosis of COVID-19 in
Thailand. Virology journal, 17(1), 177. https://doi.org/10.1186/s12985-020-01452-5
Chen LK. (2021). COVID‐19 vaccination and frailty in older adults. Arch Gerontol Geriatr, 96:104487.
https://doi: 10.1016/j.archger.2021.104487
Cömert, SŞ., Kıral, N. (2020). Radiological Findings ofCOVID-19 Pneumonia. Southern Clinics of Istanbul
Eurasia, 31: 16-22.https://doi.org/10.14744/scie.2020.96158
Diken ÖE. (2021). SARS-CoV, MERS-CoV Neler Öğrendik? SARS-CoV2 ile Farklılıkları. ASYOD Güncel Göğüs
Hastalıkları Serisi Kitapları. In: Karadağ M. Ankara: Dünya Tıp Kitapevi. 35-43.
Eastin, C., Eastin, T. (2020). Clinical Characteristics of Coronavirus Disease 2019 in China: Guan W, Ni Z, Hu
Y, et al. N Engl J Med. 2020 Feb 28 [Online ahead of print] DOI: 10.1056/NEJMoa2002032. The Journal of
Emergency Medicine, 58(4), 711–712. https://doi.org/10.1016/j.jemermed.2020.04.004
Fang, X., Li, S., Yu, H., Wang, P., Zhang, Y., Chen, Z., Li, Y., Cheng, L., Li, W., Jia, H., Ma, X. (2020). Epidemiological,
comorbidity factors with severity and prognosis of COVID-19: a systematic review and metaanalysis. Aging, 12(13), 12493–12503.
https://doi.org/10.18632/aging.103579 Ganesan, R., Mahajan, V., Singla, K., Konar, S., Samra, T.,
Sundaram, S. K., Suri, V., Garg, M., Kalra, N., Puri, G. D.(2021). Mortality Prediction of COVID-19 Patients at
Intensive Care Unit Admission. Cureus, 13(11), 19690. https://doi.org/10.7759/cureus.19690
Gao, Q., Bao, L., Mao, H., Wang, L., Xu, K., Yang, M., Li, Y.,Zhu, L., Wang, N., Lv, Z., Gao, H., Ge, X., Kan, B., Hu, Y.,
Liu, J., Cai, F., Jiang, D., Yin, Y., Qin, C., Li, J., … Qin, C.(2020). Development of an inactivated vaccinecandidate for SARS-CoV-2. Science (New York,N.Y.), 369(6499), 77–81. https://doi.org/10.1126/science.abc1932
Hani, C., Trieu, N. H., Saab, I., Dangeard, S., Bennani, S.,Chassagnon, G., Revel, M. P. (2020). COVID-19 pneumonia: A review of typical CT findings and differential diagnosis. Diagnostic and interventional imaging, 101(5), 263–268. https://doi.org/10.1016/j.diii.2020.03.014
Hodgson, S. H., Mansatta, K., Mallett, G., Harris, V., Emary, K. R. W., Pollard, A. J. (2021). What defines an
efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines
against SARS-CoV-2. The Lancet. Infectious diseases, 21(2), 26–35.
https://doi.org/10.1016/S1473-3099(20)30773-8
Hussin, A., Rothan and Siddappa, N. Byrareddy. (2020).The epidemiology and pathogenesis of coronavirus
disease (COVID-19) outbreak. J Autoimmun, 09: 102433. https://doi.org/10.1016/j.jaut.2020.102433
Jara, A., Undurraga, E. A., González, C., Paredes, F., Fontecilla, T., Jara, G., Pizarro, A., Acevedo, J., Leo, K.,
Leon, F., Sans, C., Leighton, P., Suárez, P., GarcíaEscorza, H., Araos, R. (2021). Effectiveness of an
Inactivated SARS-CoV-2 Vaccine in Chile. The New England journal of medicine, 385(10), 875–884.
https://doi.org/10.1056/NEJMoa2107715
Liu, W., Tao, Z. W., Wang, L., Yuan, M. L., Liu, K., Zhou, L., Wei, S., Deng, Y., Liu, J., Liu, H. G., Yang, M., Hu, Y.
(2020). Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel
coronavirus disease. Chinese medical journal, 133(9),1032–1038. https://doi.org/10.1097/CM9.0000000000000775
McGill COVID19 Vaccine Tracker Team. Sinovac: CoronaVac. https://covid19.trackvaccines.org/vaccines/7/
(accessed April 28, 2021).
Inactivated SARS-CoV-2 vaccine candidates have shown promising results in
preclinical trials 13. Palacios, R., Batista. AP., Albuquerque. CSN., Patiño. EG.,
Pan, F., Ye, T., Sun, P., Gui, S., Liang, B., Li, L., Zheng, D.,Wang, J., Hesketh, R. L., Yang, L., Zheng, C. (2020).
Time Course of Lung Changes at Chest CT during Recovery from Coronavirus Disease 2019 (COVID19). Radiology, 295(3), 715–721. https://doi.org/10.1148/radiol.2020200370
Roghani, A. (2021). The Influence of Covid-19 Vaccine on Daily Cases, Hospitalization, and Death Rate in
Tennessee: A Case Study inthe United States. MedRxiv. https://doi.org/10.2196/29324
Song, J. Y., Yun, J. G., Noh, J. Y., Cheong, H. J., Kim, W. J. (2020). Covid-19 in South Korea - Challenges of
Subclinical Manifestations. The New England journal of medicine, 382(19), 1858–1859.
https://doi.org/10.1056/NEJMc2001801
Tanriover, M. D., Doğanay, H. L., Akova, M., Güner, H. R., Azap, A., Akhan, S., Köse, Ş., Erdinç, F. Ş., Akalın, E. H.,
Tabak, Ö. F., Pullukçu, H., Batum, Ö., Şimşek Yavuz, S., Turhan, Ö., Yıldırmak, M. T., Köksal, İ., Taşova, Y.,
Korten, V., Yılmaz, G., Çelen, M. K., CoronaVac Study Group (2021). Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a double-blind, randomised, placebocontrolled, phase 3 trial in Turkey. Lancet (London, England), 398(10296), 213–222.
https://doi.org/10.1016/S0140-6736(21)01429-X
Vasileiou, E., Simpson, C. R., Shi, T., Kerr, S., Agrawal, U., Akbari, A., Bedston, S., Beggs, J., Bradley, D., Chuter,
A., de Lusignan, S., Docherty, A. B., Ford, D., Hobbs, F. R., Joy, M., Katikireddi, S. V., Marple, J., McCowan, C.,
McGagh, D., McMenamin, J., … Sheikh, A. (2021). Interim findings from first-dose mass COVID-19 vaccination roll-out and COVID-19 hospital admissions in Scotland: a national prospective cohort
study. Lancet (London, England), 397(10285), 1646– 1657. https://doi.org/10.1016/S0140-6736(21)00677-
2
Wilder-Smith, A., Mulholland, K. (2021). Effectiveness of an Inactivated SARS-CoV-2 Vaccine. N Engl J Med,
385(10): 946–948. https://doi.org/10.1056/NEJMe2111165.
World Health Organization. WHO Coronavirus (COVID-19) Dashboard. (2022a). Available from
https://covid19.who.int/
World Health Organization. WHO Coronavirus (COVID-19) Dashboard. TÜRKİYE; (2022b). Available from
https://covid19.who.int/region/euro/country/tr.
World Health Organization. WHO Coronavirus (COVID-19) Dashboard. (2022c). Available from https://www.who.int/news-room/featurestories/detail/the-sinovac-covid-19-vaccine-whatyou-need-to-know.
Yang, L., Liu, J., Zhang, R., Li, M., Li, Z., Zhou, X., Hu, C., Tian,F., Zhou, F., Lei, Y. (2020). Epidemiological and clinical
features of 200 hospitalized patients with corona virusdisease 2019 outside Wuhan, China: A descriptive
study. Journal of clinical virology: the official publication of the Pan American Society for Clinical
Virology, 129, 104475. https://doi.org/10.1016/j.jcv.2020.104475
Ye, Z., Zhang, Y., Wang, Y., Huang, Z., Song, B. (2020). Chest CT manifestations of new coronavirus disease
2019 (COVID-19): a pictorial review. European radiology, 30(8), 4381–4389.
https://doi.org/10.1007/s00330-020-06801-0
Yorsaeng, R., Suntronwong, N., Phowatthanasathian, H., Assawakosri, S., Kanokudom, S., Thongmee, T.,
Vichaiwattana, P., Auphimai, C., Wongsrisang, L., Srimuan, D., Thatsanatorn, T., Klinfueng, S.,
Sudhinaraset, N., Wanlapakorn, N., Poovorawan, Y. (2022). Immunogenicity of a third dose viral-vectored
COVID-19 vaccine after receiving two-dose inactivated vaccines in healthy adults. Vaccine, 40(3), 524–530.
https://doi.org/10.1016/j.vaccine.2021.11.083
Zhang, Y., Zeng, G., Pan, H., Li, C., Hu, Y., Chu, K., Han, W., Chen, Z., Tang, R., Yin, W., Chen, X., Hu, Y., Liu, X., Jiang,
C., Li, J., Yang, M., Song, Y., Wang, X., Gao, Q., Zhu, F. (2021). Safety, tolerability, and immunogenicity of an
inactivated SARS-CoV-2 vaccine in healthy adults aged 18-59 years: a randomised, double-blind, placebo controlled, phase 1/2 clinical trial. The Lancet. Infectious diseases, 21(2), 181–192.
https://doi.org/10.1016/S1473-3099(20)30843-4
Zhang, Z. L., Hou, Y. L., Li, D. T., Li, F. Z. (2020). Laboratory findings of COVID-19: a systematic review and metaanalysis. Scandinavian journal of clinical and laboratory investigation, 80(6), 441–447.
https://doi.org/10.1080/00365513.2020.1768587
Year 2023,
Volume: 4 Issue: 2, 147 - 154, 31.05.2023
Amato, M. K., Hennessy, C., Shah, K., Mayer, J. (2021).Multisystem Inflammatory Syndrome in an Adult. The
Journal of emergency medicine, 61(1), 1–3. https://doi.org/10.1016/j.jemermed.2021.02.007
Chaimayo, C., Kaewnaphan, B., Tanlieng, N., Athipanyasilp, N., Sirijatuphat, R., Chayakulkeeree, M.,
Angkasekwinai, N., Sutthent, R., Puangpunngam, N.,Tharmviboonsri, T., Pongraweewan, O., Chuthapisith,
S., Sirivatanauksorn, Y., Kantakamalakul, W.,Horthongkham, N. (2020). Rapid SARS-CoV-2 antigen
detection assay in comparison with real-time RT-PCRassay for laboratory diagnosis of COVID-19 in
Thailand. Virology journal, 17(1), 177. https://doi.org/10.1186/s12985-020-01452-5
Chen LK. (2021). COVID‐19 vaccination and frailty in older adults. Arch Gerontol Geriatr, 96:104487.
https://doi: 10.1016/j.archger.2021.104487
Cömert, SŞ., Kıral, N. (2020). Radiological Findings ofCOVID-19 Pneumonia. Southern Clinics of Istanbul
Eurasia, 31: 16-22.https://doi.org/10.14744/scie.2020.96158
Diken ÖE. (2021). SARS-CoV, MERS-CoV Neler Öğrendik? SARS-CoV2 ile Farklılıkları. ASYOD Güncel Göğüs
Hastalıkları Serisi Kitapları. In: Karadağ M. Ankara: Dünya Tıp Kitapevi. 35-43.
Eastin, C., Eastin, T. (2020). Clinical Characteristics of Coronavirus Disease 2019 in China: Guan W, Ni Z, Hu
Y, et al. N Engl J Med. 2020 Feb 28 [Online ahead of print] DOI: 10.1056/NEJMoa2002032. The Journal of
Emergency Medicine, 58(4), 711–712. https://doi.org/10.1016/j.jemermed.2020.04.004
Fang, X., Li, S., Yu, H., Wang, P., Zhang, Y., Chen, Z., Li, Y., Cheng, L., Li, W., Jia, H., Ma, X. (2020). Epidemiological,
comorbidity factors with severity and prognosis of COVID-19: a systematic review and metaanalysis. Aging, 12(13), 12493–12503.
https://doi.org/10.18632/aging.103579 Ganesan, R., Mahajan, V., Singla, K., Konar, S., Samra, T.,
Sundaram, S. K., Suri, V., Garg, M., Kalra, N., Puri, G. D.(2021). Mortality Prediction of COVID-19 Patients at
Intensive Care Unit Admission. Cureus, 13(11), 19690. https://doi.org/10.7759/cureus.19690
Gao, Q., Bao, L., Mao, H., Wang, L., Xu, K., Yang, M., Li, Y.,Zhu, L., Wang, N., Lv, Z., Gao, H., Ge, X., Kan, B., Hu, Y.,
Liu, J., Cai, F., Jiang, D., Yin, Y., Qin, C., Li, J., … Qin, C.(2020). Development of an inactivated vaccinecandidate for SARS-CoV-2. Science (New York,N.Y.), 369(6499), 77–81. https://doi.org/10.1126/science.abc1932
Hani, C., Trieu, N. H., Saab, I., Dangeard, S., Bennani, S.,Chassagnon, G., Revel, M. P. (2020). COVID-19 pneumonia: A review of typical CT findings and differential diagnosis. Diagnostic and interventional imaging, 101(5), 263–268. https://doi.org/10.1016/j.diii.2020.03.014
Hodgson, S. H., Mansatta, K., Mallett, G., Harris, V., Emary, K. R. W., Pollard, A. J. (2021). What defines an
efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines
against SARS-CoV-2. The Lancet. Infectious diseases, 21(2), 26–35.
https://doi.org/10.1016/S1473-3099(20)30773-8
Hussin, A., Rothan and Siddappa, N. Byrareddy. (2020).The epidemiology and pathogenesis of coronavirus
disease (COVID-19) outbreak. J Autoimmun, 09: 102433. https://doi.org/10.1016/j.jaut.2020.102433
Jara, A., Undurraga, E. A., González, C., Paredes, F., Fontecilla, T., Jara, G., Pizarro, A., Acevedo, J., Leo, K.,
Leon, F., Sans, C., Leighton, P., Suárez, P., GarcíaEscorza, H., Araos, R. (2021). Effectiveness of an
Inactivated SARS-CoV-2 Vaccine in Chile. The New England journal of medicine, 385(10), 875–884.
https://doi.org/10.1056/NEJMoa2107715
Liu, W., Tao, Z. W., Wang, L., Yuan, M. L., Liu, K., Zhou, L., Wei, S., Deng, Y., Liu, J., Liu, H. G., Yang, M., Hu, Y.
(2020). Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel
coronavirus disease. Chinese medical journal, 133(9),1032–1038. https://doi.org/10.1097/CM9.0000000000000775
McGill COVID19 Vaccine Tracker Team. Sinovac: CoronaVac. https://covid19.trackvaccines.org/vaccines/7/
(accessed April 28, 2021).
Inactivated SARS-CoV-2 vaccine candidates have shown promising results in
preclinical trials 13. Palacios, R., Batista. AP., Albuquerque. CSN., Patiño. EG.,
Pan, F., Ye, T., Sun, P., Gui, S., Liang, B., Li, L., Zheng, D.,Wang, J., Hesketh, R. L., Yang, L., Zheng, C. (2020).
Time Course of Lung Changes at Chest CT during Recovery from Coronavirus Disease 2019 (COVID19). Radiology, 295(3), 715–721. https://doi.org/10.1148/radiol.2020200370
Roghani, A. (2021). The Influence of Covid-19 Vaccine on Daily Cases, Hospitalization, and Death Rate in
Tennessee: A Case Study inthe United States. MedRxiv. https://doi.org/10.2196/29324
Song, J. Y., Yun, J. G., Noh, J. Y., Cheong, H. J., Kim, W. J. (2020). Covid-19 in South Korea - Challenges of
Subclinical Manifestations. The New England journal of medicine, 382(19), 1858–1859.
https://doi.org/10.1056/NEJMc2001801
Tanriover, M. D., Doğanay, H. L., Akova, M., Güner, H. R., Azap, A., Akhan, S., Köse, Ş., Erdinç, F. Ş., Akalın, E. H.,
Tabak, Ö. F., Pullukçu, H., Batum, Ö., Şimşek Yavuz, S., Turhan, Ö., Yıldırmak, M. T., Köksal, İ., Taşova, Y.,
Korten, V., Yılmaz, G., Çelen, M. K., CoronaVac Study Group (2021). Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a double-blind, randomised, placebocontrolled, phase 3 trial in Turkey. Lancet (London, England), 398(10296), 213–222.
https://doi.org/10.1016/S0140-6736(21)01429-X
Vasileiou, E., Simpson, C. R., Shi, T., Kerr, S., Agrawal, U., Akbari, A., Bedston, S., Beggs, J., Bradley, D., Chuter,
A., de Lusignan, S., Docherty, A. B., Ford, D., Hobbs, F. R., Joy, M., Katikireddi, S. V., Marple, J., McCowan, C.,
McGagh, D., McMenamin, J., … Sheikh, A. (2021). Interim findings from first-dose mass COVID-19 vaccination roll-out and COVID-19 hospital admissions in Scotland: a national prospective cohort
study. Lancet (London, England), 397(10285), 1646– 1657. https://doi.org/10.1016/S0140-6736(21)00677-
2
Wilder-Smith, A., Mulholland, K. (2021). Effectiveness of an Inactivated SARS-CoV-2 Vaccine. N Engl J Med,
385(10): 946–948. https://doi.org/10.1056/NEJMe2111165.
World Health Organization. WHO Coronavirus (COVID-19) Dashboard. (2022a). Available from
https://covid19.who.int/
World Health Organization. WHO Coronavirus (COVID-19) Dashboard. TÜRKİYE; (2022b). Available from
https://covid19.who.int/region/euro/country/tr.
World Health Organization. WHO Coronavirus (COVID-19) Dashboard. (2022c). Available from https://www.who.int/news-room/featurestories/detail/the-sinovac-covid-19-vaccine-whatyou-need-to-know.
Yang, L., Liu, J., Zhang, R., Li, M., Li, Z., Zhou, X., Hu, C., Tian,F., Zhou, F., Lei, Y. (2020). Epidemiological and clinical
features of 200 hospitalized patients with corona virusdisease 2019 outside Wuhan, China: A descriptive
study. Journal of clinical virology: the official publication of the Pan American Society for Clinical
Virology, 129, 104475. https://doi.org/10.1016/j.jcv.2020.104475
Ye, Z., Zhang, Y., Wang, Y., Huang, Z., Song, B. (2020). Chest CT manifestations of new coronavirus disease
2019 (COVID-19): a pictorial review. European radiology, 30(8), 4381–4389.
https://doi.org/10.1007/s00330-020-06801-0
Yorsaeng, R., Suntronwong, N., Phowatthanasathian, H., Assawakosri, S., Kanokudom, S., Thongmee, T.,
Vichaiwattana, P., Auphimai, C., Wongsrisang, L., Srimuan, D., Thatsanatorn, T., Klinfueng, S.,
Sudhinaraset, N., Wanlapakorn, N., Poovorawan, Y. (2022). Immunogenicity of a third dose viral-vectored
COVID-19 vaccine after receiving two-dose inactivated vaccines in healthy adults. Vaccine, 40(3), 524–530.
https://doi.org/10.1016/j.vaccine.2021.11.083
Zhang, Y., Zeng, G., Pan, H., Li, C., Hu, Y., Chu, K., Han, W., Chen, Z., Tang, R., Yin, W., Chen, X., Hu, Y., Liu, X., Jiang,
C., Li, J., Yang, M., Song, Y., Wang, X., Gao, Q., Zhu, F. (2021). Safety, tolerability, and immunogenicity of an
inactivated SARS-CoV-2 vaccine in healthy adults aged 18-59 years: a randomised, double-blind, placebo controlled, phase 1/2 clinical trial. The Lancet. Infectious diseases, 21(2), 181–192.
https://doi.org/10.1016/S1473-3099(20)30843-4
Zhang, Z. L., Hou, Y. L., Li, D. T., Li, F. Z. (2020). Laboratory findings of COVID-19: a systematic review and metaanalysis. Scandinavian journal of clinical and laboratory investigation, 80(6), 441–447.
https://doi.org/10.1080/00365513.2020.1768587
Koca, E., Kutlusoy, S., Aydın, A., Kasapoğlu, U. S. (2023). The influence of SARS-CoV-2 vaccination on 28-day mortality and hospitalization rate of COVID-19 patients under 40 years. Turkish Journal of Science and Health, 4(2), 147-154. https://doi.org/10.51972/tfsd.1209277