Abstract
Aim :Skeletal muscle wasting is closely correlated with the prognosis of patients diagnosed with gastric cancer. In our study, we aimed to investigate the effect of measuring skeletal muscle density with computed tomography on survival.
Materials and Methods:A total of 62 patients were included in the study. Skeletal muscle density (HUAC) was measured. Univariate and multivaritecox regression analyzes were performed to determine the factors affecting survival.
Results:A significant correlation was found between survival and stage, lymphovascular invasion, perineuralinvasion, and whether or not to receive adjuvant therapy. The survival of male and female patients with low HUAC values was significantly worse in both univariate and multivariate analysis.
Conclusion:In our study, we demonstrated the independent association of preoperative HUAC measurement with survival in patients with early stage gastric cancer. Survival rates were found to be significantly lower in patients with low skeletal muscle density.
References
- 1. Bray, F., et al., Global cancer transitions according to the Human Development Index (2008-2030): a population-based study. Lancet Oncol, 2012; 13: 790-801.
- 2. Thrumurthy, S.G., et al., The diagnosis and management of gastric cancer. BMJ, 2013; 347: 6367.
- 3. Kim, Y., et al., Conditional survival after surgical resection of gastric cancer: a multi-institutional analysis of the us gastric cancer collaborative. Ann Surg Oncol, 2015; 22: 557-64.
- 4. Esfahani, A., et al., A new score for screening of malnutrition in patients with inoperable gastric adenocarcinoma. Jpn J Clin Oncol, 2017; 47: 475-9.
- 5. Morley, J.E., et al., Sarcopenia. J Lab Clin Med, 2001; 137: 231-43.
- 6. Kuwada, K., et al., Sarcopenia and Comorbidity in Gastric Cancer Surgery as a Useful Combined Factor to Predict Eventual Death from Other Causes. Ann Surg Oncol, 2018; 25: 1160-6.
- 7. Munoz-Rodriguez, J., et al., Effect of muscle density in patients with metastatic prostate cancer administered androgen deprivation therapy. Endocrinol Diabetes Nutr (Engl Ed), 2021; 68: 92-8.
- 8. Harada, K., et al., Prognostic and clinical impact of sarcopenia in esophageal squamous cell carcinoma. Dis Esophagus, 2016; 29: 627-33.
- 9. Prado, C.M., et al., Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. Lancet Oncol, 2008; 9: 629-35.
- 10. Fukushima, H., et al., Prognostic Significance of Sarcopenia in Patients with Metastatic Renal Cell Carcinoma. J Urol, 2016; 195: 26-32.
- 11. Shen, W., et al., Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image. J Appl Physiol (1985), 2004; 97: 2333-8.
- 12. Perez Camargo, D.A., et al., Assessment and Impact of Phase Angle and Sarcopenia in Palliative Cancer Patients. Nutr Cancer, 2017; 69: 1227-33.
Abstract
Amaç : İskelet kas kaybı mide kanseri tanısı almış hastaların prognozu ile yakın koreledir. Çalışmamızda iskelet kas dansitesinin bilgisayarlı tomografi ile ölçümünün sağkalım üzerine etkisini araştırmayı amaçladık.
Gereç ve yöntemler: Çalışmaya toplam 62 hasta dahil edildi. İskelet kas dansitesi (HUAC) ölçümü yapıldı. Sağkalım üzerine etki eden faktörleri saptamak için ünivariate ve multivarite cox regresyon analizi yapıldı.
Bulgular: Evre, lenfovasküler invazyon, perinöral invazyon ve adjuvan tedavi alıp almama durumu ile sağkalım arasında anlamlı ilişki saptandı. HUAC değeri düşük olan erkek ve kadın hastaların sağkalımları hem ünivariate hem de multivariate analizde anlamlı olarak kötü tesbit edildi.
Sonuç: çalışmamızda erken evre mide kanserli hastalarda operasyon öncesi HUAC ölçümünün sağkalım ile bağımsız olarak ilişkisini gösterdik. İskelet kas dansitesi düşük olan hastalarda sağkalımlar anlamlı olarak düşük saptandı.
References
- 1. Bray, F., et al., Global cancer transitions according to the Human Development Index (2008-2030): a population-based study. Lancet Oncol, 2012; 13: 790-801.
- 2. Thrumurthy, S.G., et al., The diagnosis and management of gastric cancer. BMJ, 2013; 347: 6367.
- 3. Kim, Y., et al., Conditional survival after surgical resection of gastric cancer: a multi-institutional analysis of the us gastric cancer collaborative. Ann Surg Oncol, 2015; 22: 557-64.
- 4. Esfahani, A., et al., A new score for screening of malnutrition in patients with inoperable gastric adenocarcinoma. Jpn J Clin Oncol, 2017; 47: 475-9.
- 5. Morley, J.E., et al., Sarcopenia. J Lab Clin Med, 2001; 137: 231-43.
- 6. Kuwada, K., et al., Sarcopenia and Comorbidity in Gastric Cancer Surgery as a Useful Combined Factor to Predict Eventual Death from Other Causes. Ann Surg Oncol, 2018; 25: 1160-6.
- 7. Munoz-Rodriguez, J., et al., Effect of muscle density in patients with metastatic prostate cancer administered androgen deprivation therapy. Endocrinol Diabetes Nutr (Engl Ed), 2021; 68: 92-8.
- 8. Harada, K., et al., Prognostic and clinical impact of sarcopenia in esophageal squamous cell carcinoma. Dis Esophagus, 2016; 29: 627-33.
- 9. Prado, C.M., et al., Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. Lancet Oncol, 2008; 9: 629-35.
- 10. Fukushima, H., et al., Prognostic Significance of Sarcopenia in Patients with Metastatic Renal Cell Carcinoma. J Urol, 2016; 195: 26-32.
- 11. Shen, W., et al., Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image. J Appl Physiol (1985), 2004; 97: 2333-8.
- 12. Perez Camargo, D.A., et al., Assessment and Impact of Phase Angle and Sarcopenia in Palliative Cancer Patients. Nutr Cancer, 2017; 69: 1227-33.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Orıgınal Artıcle |
| Authors | |
| Publication Date | March 26, 2022 |
| Published in Issue | Year 2022 |
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e-ISSN: 2149-8296
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