HEART RATE VARIABILITY IS AFFECTED IN YOUNG ADULT CELIAC PATIENTS, INDICATING AUTONOMIC DYSFUNCTION AND INCREASED CARDIOVASCULAR RISK

Year 2022, , 525 - 533, 30.12.2022

Eliz Uzel , Sezen Uzunget

https://doi.org/10.18663/tjcl.1182275

Abstract

Aim: Celiac Disease (CD) is a common autoimmune disease that can present at any age with varied symptoms. Cardiac involvement including vascular and arrhythmic disturbances has an important prognostic value in patients with autoimmune disorders. The aim of this study was to evaluate the effects of CD on cardiovascular autonomic functions by measuring the indices of heart rate variability (HRV).
Materials and Methods: Ninety-one CD patients and the ninety-three healthy volunteers were included in the study. We examined both time domain and frequency domain indices of HRV measured by 24-hour ambulatory electrocardiography.
Results: All of the time domain and frequency domain HRV parameters, with the exceptions of low frequency power and low frequency to high frequency ratio, were significantly lower in patients with CD compared to the control (p < 0.01). This difference retained for most of the HRV parameters when daytime and nighttime HRV parameters were compared separately. Correlation analysis revealed significant associations of HRV parameters with hemoglobin and ferritin levels and with duration of CD (p < 0.01). No correlation was found between HRV parameters and anti-tissue transglutaminase IgA and IgG levels which indicate the activity of the disease.
Conclusion: The study confirmed that patients with CD have reduced HRV, indicating the presence of objective autonomic dysfunction and increased cardiovascular risk.

Keywords

autonomic dysfunction, Celiac disease, heart rate variability

Thanks

We owe MD, Assoc Prof. IO a dept of gratitude and we would like to thank him for referring and providing us guidance for patients with celiac disease.

GENÇ YETİŞKİN ÇÖLYAK HASTALARINDA BOZULMUŞ KALP HIZI DEĞİŞKENLİĞİ OTONOMİK BOZUKLUK VE ARTMIŞ KARDİYOVASKÜLER RİSK

Abstract

Amaç: Çölyak Hastalığı, her yaşta çeşitli semptomlarla ortaya çıkabilen yaygın bir otoimmün hastalıktır. Vasküler ve aritmik bozuklukları içeren kalp tutulumu, otoimmün bozukluğu olan hastalarda önemli bir prognostik değere sahiptir. Bu çalışmanın amacı, kalp hızı değişkenliği (KHD) parametrelerini ölçerek, çölyak hastalığının kardiyovasküler otonomik fonksiyonlar üzerindeki etkilerini değerlendirmektir.
Gereç ve Yöntemler: Doksan bir çölyak hastası ve doksan üç sağlıklı gönüllü çalışmaya dahil edildi. 24 saatlik ayaktan elektrokardiyografi ile ölçülen kalp hızı değişkenliğinin hem zaman alanı hem de frekans alanı endekslerini inceledik.
Bulgular: Düşük frekanslı güç ve düşük frekans-yüksek frekans oranı hariç tüm zaman alanı ve frekans alanı KHD parametreleri, kontrole kıyasla çölyak hastalarında önemli ölçüde daha düşüktü (p < 0.01). Bu fark, gündüz ve gece KHD parametreleri ayrı ayrı karşılaştırıldığında, KHD parametrelerinin çoğu için korunmuştur. Korelasyon analizi, KHD parametrelerinin hemoglobin ve ferritin seviyeleri ve hastalık süresi ile önemli ilişkilerini ortaya çıkardı (p < 0.01). KHD parametreleri ile hastalığın aktivitesine işaret eden anti-doku transglutaminaz IgA ve IgG seviyeleri arasında korelasyon bulunmadı.
Sonuç: Çalışma, çölyaklı hastaların KHD’Yİ azalttığını doğruladı, bu da objektif otonomik disfonksiyon ve artmış kardiyovasküler riskin varlığına işaret etmektedir.

Keywords

otonom disfonksiyon, çölyak hastalığı, kalp hızı değişkenliği

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