Prognostıc Factors In Testıcular Cancer

Year 2024, , 176 - 181, 01.07.2024

Yasin Sezgin , Oğur Karhan , Abdurrahman Biçer , Serdy İleri , Halis Yerlikaya , Sezai Tunç , İbrahim Aydın , Muslih Ürün , Mehmet Naci Aldemir

https://doi.org/10.18663/tjcl.1445426

Abstract

Aim: Testicular cancer is the most common cancer in men aged 15-35 years and accounts for 1% of all lifetime male cancers. There are two histologic subtypes: seminoma and nonseminoma. In our study, we aimed to investigate the factors predicting recurrence in early-stage testicular cancer.
Materials and Methods: Our study is a retrospective study of early stage testicular cancer admitted to the medical oncololi clinic of our hospital between 2006-2018. During the study, 344 patient files were reviewed and 130 patients who met the study criteria were included in the study. Our primary aim in this study was to investigate the factors predictive of recurrence in early stage testicular cancer.
Results: When evaluating PFS in patients with nonseminoma with and without lymphovascular invasion, no median PFS value was reached in either group. However, PFS was worse in patients with LVI (p=0.037). When comparing stage 1 with stage 2 seminoma patients, no median PFS values could be reached, but there was a statistical difference between the two groups in terms of recurrence (p=0.019).
Conclusions: In our study, we found no association between tumor size, embryonal carcinoma predominance, tunica albuginea invasion, spermatic cord involvement and tumor marker values and recurrence in nonseminoma germ cell testicular tumors. PFS was shorter in patients with LVI compared to those without LVI. Lymphovascular invasion, spermatic cord involvement, tunica albuginea involvement, and rete testis involvement were not associated with disease recurrence in seminoma patients, whereas higher disease stage predicted the risk of recurrence.

Keywords

Prognosis, Cancer, Testicular Germ Cell Tumor

Testis Kanserinde Prognostik Faktörler

Abstract

Amaç: testis kanserleri 15-35 yaş arası erkeklerde en sık görülen kanser olup tüm yaşam boyu erkek kanserlerinin %1’ini oluşturmaktadır. Seminom ve nonseminom olarak iki histolojik subtipi vardır. Çalışmamızda erken evre testis kanserlerinde nüksü predikte eden faktörleri araştırmayı amaçladık
Gereç ve Yöntemler: Çalışmamız, 2006-2018 yılları arasında hastanemiz Tıbbi onkololi kliniğine başvuran erken evre testis kanserlerinin incelendiği retrospektif bir çalışmadır. Çalışma sırasında 344 hasta dosyası taranmış olup çalışma kriterlerine uyan 130 hasta çalışmaya dahil edildi. Bu çalışmada primer amacımız erken evre testis kanserlerinde nüksü predikte eden faktörleri araştırmaktı.
Bulgular: Nonseminoma hastalarında Lenfovasküler invazyonu olan ve olmayan hastaların PFS açısından yapılan değerlendirmede, her iki grupta da median PFS değerine ulaşılamadı. Ancak LVİ olan hastalarda PFS daha kötü olarak saptandı (p=0.037). Seminom hastalarında evre 1 ile evre 2’nin karşılaştırılmasında median PFS değerlerine ulaşılamadı, ancak iki grup arasında rekürrens açısından istatiksel farklılık vardı (p=0.019)
Sonuçlar: Çalışmamızda nonseminom germ hücreli testis tümörlerinde tümör boyutu, embriyonel karsinom predominans, tunika albuginea invazyonu, spermatik kord tutulumu ve tümör markır değerleri ile nüks arasında bir ilişki saptamadık. LVİ olan ve olmayanlar kıyaslandığında, LVİ olan hastalarda PFS daha kısa idi. Seminom hastalarında lenfovasküler invazyon, spermatik kord tutulumu, tunika albuginea tutulumu ve rete testis tutulumu ile hastalık rekürensi arasında ilişki izlenmezken, hastalığın evresinin yüksek olması rekürrens riskini predikte etmekte idi.

Keywords

prognoz, kanser, testis germhücreli kanser

Ethical Statement

bu çalışmanın etik onamı 16.07.2020 tarihinde 270 numara ile Dicle Üniversitesi girişimsel olmayan klinik araştırmalar etik kurulundan alınmıştır

Supporting Institution

Yok

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