Abstract
Küçük hücre dışı akciğer kanseri için önerilen 8. TNM sınıflandırmasında tümör boyutunda, 5cm’ye kadar her santiminin yeniden tanımlandığı (T1a-c ve T2a,b) ve bu şekilde tümör boyutunun prognoz açısından öneminin vurgulandığı göze çarpmaktadır. Minimal invazif adenokarsinomun T1a(mi) olarak eklendiği, akciğerin parsiyel veya total atelektazisi durumunda fark gözetilmeden aynı grupta (T2) yer aldığı, diafragma invazyonunun kötü prognoz göstermesi nedeniyle bir üst kategoriye (T4) çıkarıldığı görülmektedir. Tümörün karinadan uzaklığın prognozu etkilemediği saptandığından proksimal tümörler bir alt katagoriye (T2) alınmıştır. N tanımlayıcılarında değişiklik önerilmemiştir. Metastazlarda ise organ sayısı ve metastaz sayısının yeniden tanımlanması (M1a-c) yapılan TNM değişiklikleri olarak özetlenebilir.
References
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- Mahar AL, Compton C, McShane LM, et al, Molecular Modellers Working Group of American Joint Committee on Cancer. Refining Prognosis in Lung Cancer: A Report on the Quality and Relevance of Clinical Prognostic Tools. J Thorac Oncol 2015; 10: 1576-89.
Abstract
References
- Rami-Porta R, Asamura H, Goldstraw P. Predicting the prognosis of lung cancer: the evolution of tumor, node and metastasis in the molecular age-challenges and opportunities. Transl Lung Cancer Res 2015; 4: 415-23.
- Rami-Porta R, Bolejack V, Giroux DJ, et al, International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee, Advisory Board Members and Participating Institutions.The IASLC lung cancer staging project: the new database to inform the eighth edition of the TNM classification of lung cancer. J Thorac Oncol 2014; 9: 1618-24.
- Waqar SN. The 8th Edition of the TNM Classification for Lung Cancer: A Step in the Right Direction. Oncology Times 2015;37: 6-8.
- Goldstraw P, Chansky K, Crowley J, et al on behalf of International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee, Advisory Boards and Participating Institutions.The IASLC lung cancer staging project: Proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification of lung cancer. J Thorac Oncol 2016; 11: 39-51.
- Günal N, Gülbahar G, Öztürk EB, Sakıncı Ü, Dural K. Akciğer kanserinde prognostik faktörler. Turk J Clin Lab 2016; 7: 39-47.
- Mahar AL, Compton C, McShane LM, et al, Molecular Modellers Working Group of American Joint Committee on Cancer. Refining Prognosis in Lung Cancer: A Report on the Quality and Relevance of Clinical Prognostic Tools. J Thorac Oncol 2015; 10: 1576-89.
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