Pankreatik duktal adenokarsinomlar ve ampüller bölge adenokarsinomlarında HSF-1 ve P53 ekspresyonlarının prognostik faktörlerle ilişkisi

Year 2017, , 168 - 174, 01.06.2017

Mehmet Zengın , Nevra Dursun , Hüsniye Esra Paşaoğlu Oğuz Koç

https://doi.org/10.18663/tjcl.284388

Abstract

Amaç: Periampüller bölge
adenokarsinomları; pankreas ve ampüller bölge tümörlerini içine alan, medikal
ve cerrahi tedaviye dirençli ve hızlı metastatik progresyon gösteren
tümörlerdir. Isı şok faktörü-1, ısı şok genlerini aktif hale getirir ve malign
transformasyon ve kanser hücrelerinde çoğalmayı kolaylaştırır. P53 ise
pankreatik kanserlerin %50'sinden fazlasında mutasyona uğrayan tümör
baskılayıcı bir gendir.  Bu çalışmada
HSF-1 ve P53 ekspresyonlarının tümör boyutu, lenf nodu metastazı, tümör evresi,
tümör diferansiasyonu ve prognoz ile ilişkisi analiz edilmiştir.

Gereç ve Yöntemler: İstanbul Eğitim ve Araştırma Hastanesi'nde uygulanan 69
pankreatikoduodenektomi materyali; HSF-1/P53 ekpresyonu,
yaş, cinsiyet, tümör lokalizasyonu, tümör
boyutu, tümör evresi, tümörün diferansiasyonu, lenf
nodu metastazı varlığı ve prognoz açısından yeniden araştırıldı.

Bulgular: Çalışmamızda, %10’un üzerinde
boyanma görülen olgularda, büyük tümör boyutu, ileri evre tümör varlığı, yüksek
dereceli tümör varlığı, pozitif lenf düğümü ve kötü prognoz daha fazla oranda
izlenmiştir.

Sonuçlar: Çalışmamız HSF-1 ve P53 ekspresyonlarının, özellikle
yüksek dereceli periampüller bölge
adenokarsinomlarının gelişiminde rol
oynadığını düşündürmektedir. Ayrıca bu iki marker, az differansiye
adenokarsinom tanısında diğer parametreler ile birlikte tercih edilebilir. 

 

Keywords

Periampüller bölge adenokarsinomları, pankreas, duktal adenokarsinom, ampulla, HSF-1, P53

Relationship of HSF-1 and P53 expressions to prognostic factors in pancreatic ductal adenocarcinomas and ampullary region adenocarcinomas

Abstract

Aim: Periampullary region
adenocarcinomas, which includes pancreatic ductal adenocarcinoma and ampullary
carcinoma is one of the malignant tumors with characterized by rapid metastatic
progression and resistant to medical and surgical treatments. Heat shock genes are activated by heat shock factor-1 and
facilitates malignant transformation and cancer cell proliferation.  P53 is a tumor suppressor gene which
mutated in more than 50% of pancreatic cancers. In
this study, the relation of paramaters which include tumor size, lymph node
metastasis, tumor stage, tumor grade and prognosis with HSF-1 and P53 expession
was analysed.

Material and Methods: 69
pancreaticoduodenectomy materials which performed in the Istanbul Education and
Research Hospital were researched entirely about the HSF-1/
P53 expression, age, gender, tumor
location, tumor size, tumor stage, tumor grade, presence of lymph node
metastasis and prognosis.

Results: In our study, tumors which stained 
>10%, had more percentage in large tumor size, advanced stage tumors,
high grade tumors, positive lymph nodes and poor prognosis.

Conclusion:
Our study suggest that HSF-1 and P53
expression plays role at carcinogenesis of
especially high grade periampullary region adenocarcinomas. In addition, these two markers may be preferred in
combination with other parameters, at the diagnosis of poor differentiated
adenocarcinomas.

                                      

Keywords

Periampullary region adenocarcinomas, pancreas, ductal adenocarcinoma, ampullary, HSF-1, P53, prognostic parameters

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