A retrospective study of influenza rapid antigen test positivity with drug prescribing and clinical symptoms

Year 2019, , 149 - 155, 12.06.2019

Derya Bayırlı Turan , Defne Gümüş , Fatma Kalaycı Yüksek , Tuba Kuruoğlu , Ayça Pamukcu Kıvanç Şerefhanoğlu

https://doi.org/10.18663/tjcl.440549

Abstract

Aim:Influenza
like illnesses (ILI) are the most prevalent reason for unnecessary antibiotic
prescribing. Our aim was to evaluate the rapid antigen test(RAT)positivity with
drug prescribing and clinical symptoms for ILI which is also a first report for
Turkey.

Material and Methods:From September 2015 to June 2017, 1200 patients with ILI were included
in this study. Nasopharyngeal swabs were taken from all enrolled patients.
Antigen test was used for rapid detection of Influenza A/B virus, and the
results were compared with clinical manifestations and drug prescriptions.  

Results:RAT
results were positive in 414 (34.5%) of 1200 patients. Fever (984
patients/82%), cough (727 patients/60.6%) and weakness (270 patients/22.5%)
were common complaints. 371 (89.6%) out of 414 RAT positive patients had fever
(p<0.01). 174 (42%) out of 414 RAT positive patients were medicated with antivirals
(p<0.01). In addition, 516 (65.6%) out of 786 RAT negative patients were
medicated with only antibacterial (p<0.01). 

Conclusion:Our results supported a positive RAT test has an improving effect on the
unnecessary antibiotic prescribing. However, in Turkey the prevalence of
antibiotic prescription rates are still very high. Therefore we suggest that,
RAT can be used effectively to reduce antibiotic usage when a quick decision is
necessary.

Keywords

Influenza like illness, drug prescribing, RAT, clinical symptoms

Influenza hızlı antijen test pozitifliğinin ilaç reçetelendirilmesi ve klinik belirtiler açısından değerlendirilmesi üzerine retrospektif çalışma

Abstract

Amaç:Influenza benzeri hastalıklar (ILI) akılcı olmayan antibiyotik
kullanımının en sık sebeplerindendir. Bu çalışmadaki amacımız, Türkiye’den ilk
bildirim olarak hızlı antijen testi (RAT) pozitifliğinin ilaç
reçetelendirilmesi ve klinik belirtiler ile ilişkisini incelemektir.

Gereç ve Yöntemler:Eylül 2015-Haziran 2017 tarihleri arasında ILI tanısı almış 1200
hasta bu araştırma kapsamında değerlendirilmiştir. Tüm hastalardan nazofarenkssürüntüleri
alınmış veInfluenza A/B tanısı amacıyla RAT ile incelenmiştir. Elde edilen
sonuçlar, hastaların klinik durumları ve reçetelendirilmiş ilaçlar ile
karşılaştırılarak değerlendirilmiştir.

Bulgular:RAT sonuçlarına göre 1200 ILI hastasının 414’ü (%34,5) Influenza
A/B pozitif bulunmuştur. ILI tanısı alan hastalarda en sık görülen belirtiler
ateş (984 hasta-%82), öksürük (727 hasta-%60,6) ve halsizlik (270 hasta-%22,5)
olarak saptanmıştır. 414 RAT pozitif saptanan hastanın 371’inde (%89,6) ateş en
sık saptanan belirti olmuştur (p<0,01). Bunun yanısıra 786 RAT negatif
hastanın 516’sına (%65,6) sadece antibakteriyel ilaç reçeteverilmiştir
(p<0,01).

Sonuç:Sonuçlarımız RAT pozitifliğinin gereksiz antibiyotik
reçetelendirilmesi üzerine olumlu bir etkiye sahip olduğunu göstermiştir. Buna
rağmen Türkiye’de klinisyenlerin antibiyotik reçetelendirme oranları yüksektir.
Sonuç olarak çalışmamızinfluenza tanısınahızla karar verilmesi gereken
durumlarda RAT kullanımının gereksiz antibiyotik reçetelendirilme oranlarını
düşüreceğini göstermiştir. 

Keywords

RAT, influenza benzeri hastalık, ilaç reçetelendirilmesi, RAT, klinik belirtiler

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