Comparison of intravenous and oral iron treatment in patients with iron deficiency anemia in postpartum period

Year 2018, , 336 - 341, 28.12.2018

Pınar Kadiroğulları , Kerem Doğa Seçkin , Olgu İçten Bafali İbrahim Polat

https://doi.org/10.18663/tjcl.468809

Cited By: 1

Abstract

Aim: The aim of the study is to
evaluate the efficacy, safety and tolerability of intravenous ferric
carboxymaltose in women with postpartum anemia compared to oral ferrous
sulfate.

Material and Methods: Our study was created by
reviewing the records from patients who had hemoglobin levels between 8 and 10
g/dl on postpartum first day, and those who received intravenous iron treatment
during hospitalization and who received oral iron treatment after discharge.
Patients in group 1; In the postpartum first day, patients who were treated
with ferric carboxymaltose treatment at a rate of 15 mg / kg maximum 1000 mg
and patients in the second group were treated with oral ferrous sulphate (100
mg) 2x1 for 6 weeks after postpartum discharge. The data of the patients in
both groups and their results were analyzed and hemoglobin, hematocrit and
ferritin levels were recorded on the postpartum 1st, 14th and 40th day.

Results: The mean age of these patients
was 29.8 ± 7.1 in group 1, and 29.0 ± 5.3 in group 2, respectively. There was
no significant difference between the groups in terms of gravidity, parity
numbers, delivery patterns and Hb and Htc levels before the treatment. The Hb and
Htc levels on first day after treatment were significantly higher in the group
1 received iv iron treatment compared to the group 2 received oral iron therapy
(p <0.005). Iv iron treatment was found to increase Hb and Htc levels
rapidly. The mean of Hb, Htc and ferritin levels on 14th day was significantly
higher in group 1 (p <0.005). No significant difference was observed between
the groups at the 40th day.

Discussion: Intravenous ferric carboxymaltose
is safe and well tolerated in the treatment of postpartum iron deficiency
anemia. Intravenous iron therapy increases the hemoglobin levels in women with
postpartum anemia faster than oral ferrous sulphate. It also fills iron store
more quickly.

Keywords

Ferric carboxymaltose, Ferrous sulfate, Intravenous treatment, Oral treatment, Postpartum iron deficiency anemia

Postpartum dönemde demir eksikliği anemisi olan hastalarda intravenöz ve oral demir tedavisinin karşılaştırması

Abstract

Amaç : Kadınlarda postpartum demir
eksikliği anemisi oldukça yaygındır. Çoğu kadın oral veya intravenöz (iv) demir
ile ya da kan transfüzyonu ile tedavi edilir. Bu çalışmanın amacı, intravenöz
ferrik karboksimaltozun postpartum anemisi olan kadınlarda ferröz sülfatla
karşılaştırıldığında etkinliğini, güvenilirliğini ve tolere edilebilirliğini
değerlendirmektir.

Gereç ve Yöntemler: Çalışmamız postpartum 1.günde
hemoglobin değeri 8 ile 10 g/dl arasında olan hastalardan, hastanede yatışı
süresince iv demir tedavisi verilen ve taburculuk sonrası oral demir tedavisi
alan hastaların dosyalarının incelenmesi ile oluşturuldu. 1.grubu oluşturan
hastalar; postpartum 1.günde 15mg/kg den maksimum 1000 mg iv ferrik
karboksimaltoz tedavisi alan (n:100), 2.grubu oluşturan hastalar ise postpartum
taburculuk ile beraber oral ferroz sulfat (100 mg) / 2x1 den 6 hafta boyunca
tedavisi düzenlenen hastalardı (n:100). Her iki grupta yer alan hastaların
sistem üzerinden bilgileri ve tetkik sonuçları incelendi ve postpartum 1.gün,
14.gün ve 40.gün hemoglobin, hematokrit ve ferritin düzeyleri kaydedildi.

Bulgular: Bu hastalardan 1. grubun yaş
ortalaması 29.8, 2. grubun yaş ortalaması 29.0 olarak
saptandı. Gruplar arasında gravida ve parite sayıları, doğum şekilleri ve
tedavi öncesi bakılan hemoglobin (Hb) ve hematokrit (Htc) değerleri arasında
fark yoktu. Tedavi sonrası 1. Gün bakılan Hb ve Htc değerleri iv demir tedavisi
alan 1.grupta, oral demir tedavisi alan 2.gruba göre anlamlı derecede yüksekti
(p<0.005). İv demir tedavisinin Hb ve Htc değerlerini hızlı artırdığı
saptandı. 14. Gün bakılan Hb, Htc ve ferritin değerleri ortalaması 1. grupta
anlamlı olarak daha yüksekti (p<0.005). Gruplar arasında 40. Gün bakılan
parametrelerde anlamlı fark görülmedi.

Tartışma : Postpartum demir eksikliği
anemisinin tedavisinde intravenöz ferrik karboksimaltoz güvenli ve iyi tolere
edilebilmektedir. İntravenöz demir tedavisinin postpartum anemisi olan
kadınlarda hemoglobin seviyesini oral ferröz sülfattan daha hızlı arttırdığı
gösterilmiştir. Ayrıca demir depolarını daha hızlı bir şekilde doldurduğu
görülmüştür.

Keywords

Demir Karboksimaltoz, Demir Sülfat, Postpartum anemi, İntravenöz tedavi, Oral tedavi

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