Evaluation of fructose consumption in individuals with non-alcoholic fatty liver disease

Year 2019, , 190 - 196, 12.06.2019

Aliye Kuyumcu , Tuğrul Pürnak Emine Akal Yıldız

https://doi.org/10.18663/tjcl.522720

Abstract

Aim: The aim of this study was to determine fructose-rich food
consumption levels of individuals with nonalcoholic fatty liver disease (NAYKH)
and to determine the possible relationship between biochemical parameters and
anthropometric measurements.         

 

Material and Methods: Individuals between 19-65 years of age with abdominal
ultrasonography (USG) with varying degrees of fatty tissue; mild steatosis
(grade 1, n=15), moderate steatosis (grade 2, n=15), severe steatosis (grade 3,
n=15) and no steatosis (grade 0, n=15). Nutritional status and 24-hour nutrient
consumption were recorded. Anthropometric measurements of individuals, some
biochemical findings, physical activity status and fructose-rich nutrition
status were investigated. 

 

Results: In this study, anthropometric measurements such as BMI, waist
circumference and waist/hip ratio increased with the increase in steatosis
degrees and were statistically significant (p<0.001). At physical activity
level, there is no significant difference between groups (p=0,099).
Daily fructose intake with nutrients is the lowest in
grade 0; Grade 2 and Grade 3 groups have similar amounts and higher than other
groups (p<0.001). The average daily consumption of fructose-rich
non-alcoholic beverages (soda and cola) was found to be at least in grade 0
(8.7 ± 5.7ml) and significantly higher in grade 3 (291 ± 33.5 ml), (p=0,001).
Furthermore, in the study individuals with fructose consumption ** BMI, **
waist circumference, * waist / hip ratio, * total cholesterol, ** uric acid, **
ALT, * AST, ** ALP, ** chocolate consumption amount, ** a significant positive
relationship was found between the consumption of ready-made fruit juice and
alcoholic beverages (* p <0.05, ** p <0.01).

 

Conclusion: In our study, there was a strong correlation between the degree
of steatosis and fructose consumption in individuals with NAYKH. It should be
kept in mind that excessive consumption of fructose with nutrients may pose a
risk for diseases such as obesity, non-alcoholic fatty liver, metabolic
syndrome and cardiovascular diseases. The consumption of fructose in daily diet
should be provided from natural sources and excessive consumption should be
avoided.

Keywords

Nonalcoholic fatty liver disease, fructose, high fructose corn syrup, body mass index

Nonalkolik yağlı karaciğer hastalığı olan bireylerde fruktoz tüketiminin değerlendirilmesi

Abstract

Aim: The aim of this study was to determine fructose-rich food
consumption levels of individuals with nonalcoholic fatty liver disease (NAYKH)
and to determine the possible relationship between biochemical parameters and
anthropometric measurements.         

 

Material and Methods: Individuals between 19-65 years of age with abdominal
ultrasonography (USG) with varying degrees of fatty tissue; mild steatosis
(grade 1, n=15), moderate steatosis (grade 2, n=15), severe steatosis (grade 3,
n=15) and no steatosis (grade 0, n=15). Nutritional status and 24-hour nutrient
consumption were recorded. Anthropometric measurements of individuals, some
biochemical findings, physical activity status and fructose-rich nutrition
status were investigated. 

 

Results: In this study, anthropometric measurements such as BMI, waist
circumference and waist/hip ratio increased with the increase in steatosis
degrees and were statistically significant (p<0.001). At physical activity
level, there is no significant difference between groups (p=0,099).
Daily fructose intake with nutrients is the lowest in
grade 0; Grade 2 and Grade 3 groups have similar amounts and higher than other
groups (p<0.001). The average daily consumption of fructose-rich
non-alcoholic beverages (soda and cola) was found to be at least in grade 0
(8.7 ± 5.7ml) and significantly higher in grade 3 (291 ± 33.5 ml), (p=0,001).
Furthermore, in the study individuals with fructose consumption ** BMI, **
waist circumference, * waist / hip ratio, * total cholesterol, ** uric acid, **
ALT, * AST, ** ALP, ** chocolate consumption amount, ** a significant positive
relationship was found between the consumption of ready-made fruit juice and
alcoholic beverages (* p <0.05, ** p <0.01).

 

Conclusion: In our study, there was a strong correlation between the degree
of steatosis and fructose consumption in individuals with NAYKH. It should be
kept in mind that excessive consumption of fructose with nutrients may pose a
risk for diseases such as obesity, non-alcoholic fatty liver, metabolic
syndrome and cardiovascular diseases. The consumption of fructose in daily diet
should be provided from natural sources and excessive consumption should be
avoided.

Keywords

Nonalkolik yağlı karaciğer hastalığı, fruktoz, yüksek fruktozlu mısır şurubu, beden kitle indeksi

References

• 1. Sonsuz A, Baysal B. Karaciğer Yağlanması ve Non Alkolik Steatohepatit. Güncel Gastroenteroloji 2011; 15: 98-106.
• 2. Falck-Ytter Y, Younossi ZM, Marchesini G, McCullough AJ. Clinical features and natural history of nonalcoholic steatosis syndromes. Semin Liver Dis 2001; 21: 17-26.
• 3. Çelebi S, Ataseven H, Mengücük E, Deveci S, Açık Y, Bahçecioğlu İH. Elazığ kent toplumunda nonalkolik yağlı karaciğerin epidemiyolojik özellikleri Akademik Gastroenteroloji Dergisi 2006; 5: 41-46.
• 4. Bayrakçı B, Günşar F. Nonalkolik Steatohepatit. Güncel Gastroenteroloji 2005; 9: 167-76.
• 5. Baumeister SE, Völzke H, Marschall P et al. Impact of Fatty Liver Disease on Health Care Utilization and Costs in a General Population: A 5-Year Observation. Gastroenterology 2008; 134: 85-94.
• 6. Gören B, Fen T. Non-Alkolik Yağlı Karaciğer Hastalığı. Turkiye Klinikleri J Med Sci 2005; 25: 841-50.
• 7. Bedogni G, Miglioli L, Masutti F, Tiribelli C, Marchesini G, Bellentani S. Prevalence of and risk factors for nonalcoholic fatty liver disease: The Dionysos nutrition and liver study. Hepatology 2005; 42: 44-52.
• 8. White JS. Straight talk about high-fructose corn syrup: what it is and what it ain't. The American Journal of Clinical Nutrition 2008; 88: 1716-21.
• 9. Tappy L, Le KA, Tran C, Paquot N. Fructose and metabolic diseases: new findings, new questions. Nutrition 2010; 26: 1044-49.
• 10. Malik VS, Popkin BM, Bray GA, Despres JP, Hu FB. Sugar-sweetened beverages, obesity, type 2 diabetes mellitus, and cardiovascular disease risk. Circulation 2010; 121: 1356-64.
• 11. Bray GA. Soft drink consumption and obesity: it is all about fructose. Current Opinion in Lipidology 2010; 21: 51-7.
• 12. Ter Horst KW, Schene MR, Holman R, Romijn JA, Serlie MJ. Effect of fructose consumption on insulin sensitivity in nondiabetic subjects: a systematic review and meta-analysis of diet-intervention trials. The American Journal of Clinical Nutrition 2016; 104: 1562-76.
• 13. Ding XQ, Wu WY, Jiao RQ et al. Curcumin and allopurinol ameliorate fructose-induced hepatic inflammation in rats via miR-200a-mediated TXNIP/NLRP3 inflammasome inhibition. Pharmacological Research 2018; 137: 64-75.
• 14. Yilmaz S, Canpolat U, Baser K, Unal S, Kuyumcu MS, Aydogdu S. Neutrophil-to-lymphocyte ratio predicts functionally significant coronary artery stenosis in patients with stable coronary artery disease. Turk Kardiyoloji Dernegi Arsivi 2018; 46: 129-35.
• 15. Pekcan G. Beslenme durumunun saptanmasi. Diyet El Kitabi Hatipoglu Yayinevi Ankara 2008; 67-141.
• 16. Han TS, van Leer EM, Seidell JC, Lean ME. Waist circumference action levels in the identification of cardiovascular risk factors: prevalence study in a random sample. Bmj. 1995; 311: 1401-405.
• 17. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organization Technical Report Series 2000; 894: 1-253.
• 18. Schofield WN. Predicting basal metabolic rate, new standards and review of previous work. Human nutrition Clinical nutrition 1985; 39: 5-41.
• 19. Vuppalanchi R, Cummings OW, Saxena R, Ulbright TM, Martis N, Jones DR, et al. Relationship among histologic, radiologic, and biochemical assessments of hepatic steatosis: a study of human liver samples. J Clin Gastroenterol 2007; 41: 206-10.
• 20. Brzek P, Gebczynski AK, Ksiazek A, Konarzewski M. Effect of calorie restriction on spontaneous physical activity and body mass in mice divergently selected for basal metabolic rate (BMR). Physiology & Behavior 2016; 161: 116-22.
• 21. Mahaling DU, Basavaraj MM, Bika AJ. Comparison of lipid profile in different grades of non-alcoholic fatty liver disease diagnosed on ultrasound. Asian Pacific Journal of Tropical Biomedicine 2013; 3: 907-12.
• 22. Zhang DM, Jiao RQ, Kong LD. High Dietary Fructose: Direct or Indirect Dangerous Factors Disturbing Tissue and Organ Functions. Nutrients 2017; 9.
• 23. Bray GA, Nielsen SJ, Popkin BM. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. The American journal of clinical nutrition. 2004; 79: 537-43.
• 24. Zelber-Sagi S, Nitzan-Kaluski D, Goldsmith R, Webb M, Blendis L, Halpern Z, et al. Long term nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD): a population based study. J Hepatol 2007; 47: 711-17.
• 25. Margetts B. FAO/WHO launch expert report on diet, nutrition and prevention of chronic diseases. Public Health Nutrition 2003; 6: 323-25.