Low prognostic nutritional index is associated with adverse outcomes in patients with hypertrophic cardiomyopathy

Year 2020, , 136 - 145, 22.06.2020

Bahar Tekin Tak , Firdevs Ayşenur Ekizler , Habibe Kafes , Serkan Çay , Elif Hande Ozcan Cetın , Özcan Özeke , Fırat Özcan , Omaç Tüfekçioğlu , Serkan Topaloğlu Dursun Aras

https://doi.org/10.18663/tjcl.731609

Abstract

Aim: The aim of the study was to investigate poor nutritional status assessed by prognostic nutritional index (PNI) on the prognosis of patients with hypertrophic cardiomyopathy(HCM).
Material and Methods: A total of 420 patients with HCM were assessed. The primary end point was defined as the occurrence of CV death that included sudden cardiac death (SCD), death due to HF and cardioembolic stroke-related death.
Results: During the follow-up, primary end point was developed in 25 (6.0%) patients. Receiver operating characteristic (ROC) analysis showed that using a cut-off level of 40, PNI predicted the occurrence of primary end point with a sensitivity of 76% and specificity of 76.7%. In the multivariate model, low PNI was significant predictor of the primary end point.
Conclusion: This study showed that lowerPNI level is an independent predictor of CV death in patients with HCM.

Keywords

cardiovascular death, hypertrophic cardiomyopathy, prognostic nutritional index

Düşük prognostik nütrisyonel indeks hipertrofik kardiyomiyopatili hastalarda kötü sonuçlar ile ilişkilidir

Abstract

Amaç: Çalışmanın amacı prognostik beslenme indeksi (PNI) ile değerlendirilen zayıf beslenme durumunun, hipertrofik kardiyomiyopatili (HKMP) hastaların prognozu üzerine etkisini araştırmaktır.
Gereç ve Yöntemler: Toplam 420 HKMP hastası değerlendirildi. Çalışmanın birincil sonlanım noktası, ani kardiyak ölüm (AKÖ), kalp yetmezliği (KY) nedenli ölüm ve kardiyo embolik inme ilişkili ölümü içeren kardiyovasküler ölüm saptanması olarak tanımlandı.
Bulgular: Takip süresi boyunca 25 (% 6.0) hastada birincil sonlanım noktası saptandı. ROC (Receiver operating characteristic curve) analizi, PNİ kesme seviyesi 40 kullanarak PNİ’nin % 76 hassasiyet ve% 76.7 özgüllük ile birincil son nokta oluşumunu öngördüğünü gösterdi. Tek değişkenli ve çok değişkenli modelde düşük PNİ değeri, primer sonlanım noktası için önemli bir belirleyici olarak saptandı.
Sonuç: Bu çalışma, düşük PNİ düzeyinin HKMP hastalarında KV ölümün bağımsız bir öngördürücüsü olduğunu göstermiştir.

Keywords

kardiyovasküler ölüm, hipertrofik kardiyomiyopati, prognostik nütrisyonel indeks

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