Evaluation of laboratory parameters in inflammatory myositis

Year 2021, , 255 - 259, 29.09.2021

Melih Pamukcu , Tuğba İzci Duran

https://doi.org/10.18663/tjcl.947989

Abstract

Aim: Polymyositis (PM) and dermatomyositis (DM) are the two most common forms of idiopathic inflammatory myositis (IIM) and they are generally rare diseases. We evaluate the relationship of C-reactive protein (CRP)/albumin ratio (CAR), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio and other inflammatory markers with IIM.
Material and Methods: 30 patients and 30 healthy volunteers aged >18 years were included. Demographic data such as age, gender were recorded. CRP, erythrocyte sedimentation rate (ESR), albumin values, leukocyte, neutrophil, lymphocyte, platelet counts were determined.
Results: The median (IQR) age of the patients and healthy volunteers were 46 (38-60) years and 45 (42-52) years, respectively. 50% of the patients had a diagnosis of DM and 50% of them had a diagnosis of PM, and the median (IQR) duration of disease was 4 (0.5-13) years. The median value of CAR was 3.6 (1.0-5.1) in the patient group and 0.3 (0.1-0.6) in the control group; the NLR was 3.4 (2.3-4.4) in the patient group, 1.8 (1.6-2.1) in the control group; PLR was 223 (157-249) in the patient group, 107 (100-125) in the control group and CAR, NLR, and PLR values between the groups were significantly different (p<0.001, p=0.002 and p=0.040, respectively).
Conclusion: CAR can be considered as a helpful assessment tool to show inflammation in patients with IIM.

Keywords

Idiopathic inflammatory myopathies, C-Reactive Protein / analysis*, Inflammation / immunology, Lymphocytes / metabolism*, Neutrophils / immunology

İnflamatuar miyozitte laboratuvar parametrelerinin değerlendirilmesi

Abstract

Amaç: Polimiyozit (PM) ve dermatomiyozit (DM), idiyopatik inflamatuar miyozitin (İİM) en sık görülen iki formudur ve genellikle nadir görülen hastalıklardır. C-reaktif protein (CRP)/albümin oranı (CAR), nötrofil/lenfosit oranı (NLR), trombosit/lenfosit oranı ve diğer inflamatuar belirteçlerin İİM ile ilişkisini değerlendirmeyi amaçladık.
Gereç ve Yöntemler: 18 yaş üstü, 30 hasta ve 30 sağlıklı gönüllü dahil edildi. Yaş, cinsiyet gibi demografik veriler kaydedildi. CRP, eritrosit sedimantasyon hızı (ESR), albümin değerleri, lökosit, nötrofil, lenfosit, trombosit sayıları belirlendi.
Bulgular: Hastaların ve sağlıklı gönüllülerin medyan (IQR) yaşı sırasıyla 46 (38-60) yıl ve 45 (42-52) yıl idi. Hastaların %50'sine DM, %50'sine PM tanısı konuldu ve ortanca (IQR) hastalık süresi 4 (0,5-13) yıldı. CAR medyan değeri hasta grubunda 3,6 (1,0-5,1) ve kontrol grubunda 0,3 (0,1-0,6); NLR hasta grubunda 3,4 (2,3-4,4), kontrol grubunda 1,8 (1,6-2,1) idi; Hasta grubunda PLR 223 (157-249), kontrol grubunda 107 (100-125) ve gruplar arasında CAR, NLR ve PLR değerleri anlamlı olarak farklıydı (sırasıyla, p<0,001, p=0,002 ve p=0,040).
Sonuç: CRP/albumin oranı, IIM'li hastalarda inflamasyonu göstermek için yararlı bir değerlendirme aracı olarak düşünülebilir.

Keywords

İdiyopatik inflamatuar miyopatiler, C-Reaktif Protein, İnflamasyon, Lenfositler, Nötrofiller

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