İlimizde helicobacter pylori sıklığının değerlendirmesi: yedi yıllık çalışma

Year 2021, , 260 - 264, 29.09.2021

İlkay Bahçeci , İlknur Esen Yıldız

https://doi.org/10.18663/tjcl.954009

Abstract

Amaç: Helicobacter pylori’ (H.pylori) ye bağlı gelişen gastrit dünyada birçok ülkede yaygın olup insanda en sık görülen kronik enfeksiyonların başında gelmektedir. Dünya Sağlık Örgütü tarafından H. pylori’nin, mide karsinogenezisinin etyolojisinde temel rol aldığının bildirilmesiyle birlikte tüm dikkatler üzerine çevrilmiştir. Çalışmada ilimizdeki H.pylori pozitifliği sıklığı ve yıllar içindeki dağılımının belirlenmesi amaçlanmıştır.
Gereç ve Yöntemler: 01.01.2013 ile 31.12.2019 tarihleri arasında Recep Tayyip Erdoğan Üniversitesi (RTEÜ) Eğitim ve Araştırma Hastanesi mikrobiyoloji laboratuvarına rutinde gelen gaita örneklerin kayıtlarının retrospektif olarak taranması şeklinde gerçekleştirilmiştir. Tüm klinik birimlerden gelen gaita örnekleri kabul edilmiş olup gelen numuneler kromatografik immünoassay bir test olan Rapid Cassette Test (Feces) (Acro, Biotech, Germany) kitleri ile hızlı antijen testleri üretici firmanın önerileri doğrultusunda çalışılmıştır.
Bulgular: Toplam 8551 hastaya ait örnek çalışıldı. 806 tanesinin sonucu pozitif olarak sonuçlandı. Çalışılan örneklerin 5270’i (%61,6) kadın hastalara aitti. Bireylerin yaş ortalaması erkeklerde ±33.4 kadınlarda ±66.6 olup yaş ortalaması ±47.2 idi. Yıllar içindeki H. pylori pozitiflik sıklığı yaklaşık %1,2 -%21,2 arasında olup ortalaması %8,9 olarak bulundu.
Sonuç: Çalışma sonucunda ilimizdeki H.pylori sıklığının ülke ortalamasının altında olduğunun görülmesine karşın yıllar içindeki sıklık artışı dikkat çekiciydi. Tanıda kullanılan hızlı antijen testi hızlı, güvenilir, basit olmasına karşın yanlış negatifliklere neden olabileceği de göz önünde bulundurulmalıdır.

Keywords

Helicobacter pylori,, hızlı antijen testi, sıklık

Supporting Institution

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Project Number

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Thanks

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Evaluation of helicobacter pylori prevalance in our city: A seven years of study

Abstract

Aim: Gastritis related to Helicobacter pylori (H.pylori) is common in many countries in the world and it is one of the most common chronic infections in humans. With the World Health Organization determining that H. pylori is involved in the etiology of gastric carcinogenesis, all attention has been turned on it. In this study, it was aimed to determine the frequency of H.pylori positivity in our province and its distribution over the years.
Materials and Methods: The study was conducted between 01.01.2013 and 31.12.2019 in Recep Tayyip Erdogan University Training and Research Hospital microbiology laboratory. Stool samples from all clinical units were accepted and the samples were studied with Rapid Cassette Test (Feces) (Acro, Biotech, Germany) which are a chromatographic immunoassay test, in accordance with the manufacturer's recommendations. The study was conducted retrospectively.
Results: A total of 8551 patient samples were studied. The results of 806 of them were positive. Of my studied samples, 5270 (61.6%) belonged to female patients. The mean age of the individuals was ±33.4 in males and ±66.6 in females and the mean age was ±47.18 years. The frequency of H. pylori positivity over the years was between 1.2% and 21.2%, with an average of 8.9%.
Conclusion: Although the findings of the study showed that the frequency in our region was below the average of our country, the frequency increased over the years. Although the rapid antigen test used in diagnosis is fast, reliable and simple it should also be taken into consideration that it may cause false negativities.

Keywords

Helicobacter pylori, rapid antigen test, prevalance

Project Number

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References

• 1. Elmer W.Koneman Çeviri A. Başustaoğlu, A.D. Helicobacter cinsi. Us Color Atlas and Textbook of Diagnostic Microbiology. Türkçe 7. Baskı 2017 : 442-3
• 2.Bofinger J.J, Fekete T, Samuel R, et al.Bacterial peritonitis caused by Kingella kingea.J. Clin Microbiol 2007; 45: 3118-20
• 3.Christensen H, Bisgaard M, Angen O, et al. Final classification of Biagaard taxon 9 Actinobacillus arthritidis sp, nov and recognition of a novel genomospecies for eguine strains of Actinobacillus lignicressi.Int J SystEvol Microbiol 2002; 52: 1239-46
• 4. Elliot SP. Rat bite fever and Streptobacillus moniloformis. Clin Microbiol Rev 2007; 20 : 13-22
• 5.Linz B, Balloux F, Moodley Y, et al. An African origin for the intimate association between humans and Helicobacter pylori. Nature 2007; 445: 915-8.
• 6.Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin 2015; 65: 87-108
• 7.IARC Helicobacter pylori Working Group. Helicobacter Pylori Eradication as a Strategy for Preventing Gasric Cancer. Lyon, France: International Agency for Research on Cancer (IARC Working Group reports, no.8); 2014.)
• 8.Jonaitis L, Pellicano R, Kupcinskas L. “Helicobacter pylori and nonmalignant upper gastrointestinal diseases,” Helicobacter, 2018; 23: 23
• 9. Malfertheiner P, Selgrad M, Bornschein J. Helicobacter pylori: clinical management. Curr Opin Gastroenterol 2012; 28 : 608-14
• 10. Georgopoulos SD, Papastergiou V, Karatapanis S. Current options for the treatment of Helicobacter pylori. Expert Opin Pharmacother 2013; 14: 211-23
• 11.Özkan TB. Çocuklarda Helicobacter pylori enfeksiyonunda seroloji, tanı ve tedavi. Uludağ Üni Tıp Fak Derg 2007; 33: 81-5
• 12. Kuloğlu E. Helicobacter Pylori Tedavisinde Kullanılan Farklı Protokollerde Eradikasyon Oranlarının Değerlendirilmesi. Atatürk Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı Uzmanlık Tezi 2019
• 13. Pounder RE, Ng D. The prevalence of Helicobacter pylori infection in different countries. Aliment Pharmacol Ther 1995; 9: 33.
• 14.Krogfelt KA, Lehours P, Mégraud F. Diagnosis of Helicobacter pylori infection. Helicobacter 2005; 10: 5-13.
• 15. Patel SK, Pratap CB, Jain AK, et al. Diagnosis of Helicobacter pylori: what should be the gold standard? World J Gastroenterol 2014; 20 : 12847-59
• 16. Gisbert JP, Trapero M, Calvet X, et al. Evaluation of three different tests for the detection of stool antigens to diagnose Helicobacter pylori infection in patients with upper gastrointestinal bleeding. Aliment Pharmacol Ther 2004; 19: 923.
• 17.Wu DC, Wu IC, Wang SW et al. Comparison of stool enzyme immunoassay and immunochromatographic method for detecting Helicobacter pylori antigens before and after erdication, Diag Microbiol Infect Dis 2006; 56: 373-8.
• 18.Balint L, Tiszai A, Kozak G, et al.Epidemiologic characteristics of Helicobacter pylori infection in southeast Hungary. World J Gastroenterol. 2019 ; 25: 6365–637
• 19.Hooi JKY, Lai WY, Ng WK, et al. Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis. Gastroenterology. 2017; 153: 420–29
• 20. Ozaydin N, Turkyilmaz SA, Cali S. Prevalence and risk factors of Helicobacter pylori in Turkey: a nationally-representative, cross-sectional, screening with the 13C-Urea breath test. BMC Public Health 2013; 13 : 1215
• 21.Korkmaz H, Fındık D, Uğurluoğlu C, et al. Reliability of Stool Antigen Tests: Investigation of the Diagnostic Value of a New Immunochromatographic Helicobacter pylori Approach in Dyspeptic Patients. Asian Pacific Journal of Cancer Prevention, 2015; 16.
• 22.Utku ÖG, Ergül B, Kaçmaz B, et al. Evaluation of the sensitivity and specificity of invasive methods used in the diagnosis of Helicobacter pylori infection. The Turkish Journal of Academic Gastroenterology 2020; 19: 1-4.
• 23.Çiftel S, Okçu N, Dursun H, et al. Helicobacter pylori prevalance in our region Güncel gastroenteroloji 20/2, 2016; 6: 157-160
• 24.Alberts CJ, Jeske R, de Martel C, et al. Helicobacter pylori sero-prevalence in six different ethnic groups living in Amsterdam: The HELIUS study. Helicobacter. 2020; 25: 12687.
• 25.Zhestkova TVBM, Lymar Y.Y, Papkov SV. The prevalence of Helicobacter pylori infection among population of Ryazan region, Russian. IP Pavlov Russian Med Biol Herald. 2019; 27: 35-40.