Hobnail/mikropapiller varyant papiller tiroid karsinomu: varyant mı, patern mi

Year 2017, Volume: 8 Issue: 3, 134 - 138, 01.06.2017

Mehmet Zengin , Feray Günver Nevra Dursun

https://doi.org/10.18663/tjcl.285075

Abstract

Papiller tiroid karsinomu, tiroid maligniteleri
arasında en sık görülen tiptir ve tüm malignitelerin %1’ini oluşturur. Klasik
papiller tiroid karsinomu oldukça iyi prognoza sahip olmakla beraber hastaların
%10’unda rekürrens, lenf nodu metastazı, uzak organ metastazı ya da mortalite
gelişebilmektedir. Bu agresiv klinik davranış çoğunlukla difüz sklerozan, uzun
hücreli ve kolumnar hücreli gibi varyantlarda görülmektedir.  Hobnail/mikropapiller varyant papiller tiroid
karsinomu, papiller tiroid karsinomunun oldukça nadir görülen, yeni tarif
edilen bir varyantıdır. Literatürde benzer şekilde çok az sayıda yayın mevcut
olup, genellikle agresiv seyrettiği ve metastaz yapma potansiyelinin klasik
papiller tiroid karsinomundan fazla olduğu bildirilmiştir. Ancak sitolojik
özellikleri ve moleküler alt yapısı tam olarak anlaşılamamıştır. Bu yazıda; hobnail/mikropapiller
varyant papiller tiroid karsinomlu bir hasta sunulmuş olup, tanı problemleri ve
malignite kriterleri literatür bilgileri gözden geçirilerek tartışılmıştır. 

Keywords

Papiller tiroid karsinomu, hobnail, mikropapiller

Hobnail/micropapillary variant papillary thyroid carcinoma: is it a variant or a pattern

Abstract

Papillary thyroid carcinoma is the most common type of
thyroid malignancies and constitutes 1% of all malignancies. Classical
papillary thyroid carcinoma is very good prognosis; but recurrence, lymph node
metastasis, distant organ metastasis or mortality can develop in 10% of
patients. This aggressive clinical behavior is more often seen in variants such
as diffuse sclerosis, tall cell and columnar cell. Hobnail/micropapillary
variant papillary thyroid carcinoma is a relatively rare, newly described variant
of papillary thyroid carcinoma. There are very few publications in the
literature and it is reported that the aggressive course and metastasizing
potential is greater than the classic papillary thyroid carcinoma. However,
their cytological properties and molecular backround are not fully understood.
In this article; a patient with hobnail/micropapillary variant papillary
thyroid carcinoma has been presented, and diagnostic problems and malignancy
criteria have been discussed by reviewing the literature.

Keywords

Papillary thyroid carcinoma, hobnail, micropapillary

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