Varis etiyopatogenezinde lökosit aktivasyonu ile apopitozisin ilişkisi

Year 2019, Volume: 10 Issue: 3, 353 - 357, 30.09.2019

Naim Boran Tümer , Erkan İriz Özlem Gülbahar Dilek Erer , Halim Soncul Elif Coşkun

https://doi.org/10.18663/tjcl.592106

Abstract

Amaç: Variköz venler alt ekstremite en sık görülen
rahatsızlıklarıdır. Bu çalışmanın amacı, lökosit
aktivasyonunun ven duvarındaki apoptozis ve variköz venlerin patogenezindeki
etkisini araştırmaktır.

Gereç ve Yöntemler: Çalışmaya variköz
venleriolan 46 hasta dahil edildi. Hastalara
semptomları, komplikasyonları veya kozmetik sebeplerle  strippingle yüksek
ligasyon, ve eksizyon yapıldı. Serum kaspaz-8 ve kaspaz-9 ölçümüleri ELİSA
kullanılarak yapıldı.

Bulgular: Sağlıklı sefalik ven ile variköz safen
ven gruplarının sonuçları  arasında istatistiksel olarak anlamlı bir fark
tespit edildi (p=0.04 and
p<0.0001). 

Sonuç: Variköz ven oluşumunun altındaki karmaşık
patofizyoloji henüz yeterince açıklanamamıştır. Hem lökosit aktivasyonunun
hemde apopitozisdeki bozulmanın variköz ven oluşumuna katkısı olduğunu
düşünmekteyiz.

Keywords

venöz yetmezlik, lökosit aktivasyonu, kaspaz, apopitozis

The relationship between leukocyte activation and apoptosis in venous insufficiency etiopathogenesis

Abstract

Aim: Varicose veins are the most common disorders of the lower extremities. The
purpose of this study is to investigate the effect of leukocyte activation in
the vein wall and apoptosis in the etiopathogenesis of varicose veins.

Material and Methods:Forty-six patients with varicose veins were included in the study. High
ligation with stripping with or without additional individual ligation and
excision was performed for symptoms, complications or cosmetic needs. ELISA was
used to measure the serum concentration of caspase-8 and caspase-9.

Results: There was a statistically significant difference between the cephalic vein
and saphenous vein groups (p=0.04 and p<0.0001 respectively).

Conclusion: As a conclusion, the complex
pathophysiology underlying varicose veins has yet to be fully defined. It is
suggested that both leukocyte activation and dysregulation of apoptosis are
associated with susceptibility for varicose vein formation however this
argument needs further research.

Keywords

Apoptosis, Venous Insufficiency, caspas, leukocyte

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