Effect of serum osmolality on 6-year survival rates in patients with acute myocardial

Year 2020, 2020 Özel Sayı, 24 - 32, 26.02.2020

Selcuk Kanat , Hakan Demirci , Yasemin Üstündağ Fatma Ezgi Can Ufuk Aydın Gökhan Ocakoğlu

https://doi.org/10.18663/tjcl.556360

Cited By: 2

Abstract

Aim: In the present study, we aimed to evaluate the
potential relationship between serum osmolality and mortality rates in a six
year of follow-up in patients with a history of acute myocardial infarction.

Material
and Methods: A retrospective
study was designed. Participants were the patients with a first attack AMI, who
were referred to our tertiary referral center for angiography. The relationship
between the biochemical values of patients who were hospitalized between the
period January 2008 - June 2009 and their survival in six years was
investigated. Clinical variables of baseline characteristics, in-hospital
management, and in-hospital adverse outcomes were recorded.

Results:
Two hundred and four patients,
174 men (85%) and 30 women (15%), were included in the study. Median serum
osmolality was 295.87 mOsm/kg. Mean follow-up time was 61.31±1.68 months. The
best cut-off value of the plasma osmolality to predict the 6-year mortality was 303.94 mOsmol/kg.

Conclusion:
The higher the osmolality, the
worse the six-year survival is in patients with
first episode AMI even in the absence of diabetes mellitus and chronic kidney
disease. We believe that hyperosmolality can be targeted in treatment and
prevention efforts as well as its use when evaluating outcomes of the cardiac
diseases.

Keywords

cardiac risk, chronic kidney disease, cut off point, mortality, osmolality

Akut miyokard enfarktüsü geçiren hastalarda serum osmolalitesinin 6 yıllık sağkalım oranlarına etkisi

Abstract

Amaç: Bu çalışmada akut miyokard
enfarktüsü öyküsü olan hastalarda altı yıllık takipte serum osmolalite ve
mortalite oranları arasındaki potansiyel ilişkiyi değerlendirmeyi amaçladık.

Gereç ve Yöntemler: Retrospektif bir çalışma
tasarlandı. Katılımcılar, anjiyografi için üçüncü basamak sevk merkezimize
yönlendirilen, ilk atak AMI atağı olan hastalardı. Ocak 2008 - Haziran 2009
arasında yatan hastaların biyokimyasal değerleri ile altı yıl içinde hayatta kalmaları
arasındaki ilişki araştırıldı. Başlangıç ​​özellikleri, hastane içi yönetim ve
hastane içi olumsuz sonuçların klinik değişkenleri kaydedildi.

Bulgular: İki yüz dört hasta, 174 erkek (%
85) ve 30 kadın (% 15) çalışmaya dahil edildi. Ortalama serum osmolalitesi
295.87 mOsm / kg idi. Ortalama takip süresi 61.31 ± 1.68 ay idi. Plazma
osmolalitesinin 6 yıllık mortaliteyi tahmin etmek için en iyi kesme değeri
303.94 mOsmol / kg idi.

Sonuç: Osmolalite ne kadar yüksek
olursa, diyabetes mellitus ve kronik böbrek hastalığı olmasa bile ilk atak
AMI'si olan hastalarda altı yıllık sağkalım daha kötüdür. Hiperosmolalitenin,
kalp hastalıklarının sonuçlarını değerlendirirken kullanımının yanı sıra tedavi
ve önleme çabalarına da hedeflenebileceğine inanıyoruz.

Keywords

kardiyak risk, kronik böbrek hastalığı, kesme noktası, mortalite, ozmolalite

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