Association between eradication success of Helicobacter pylori with presence of non-alcoholic fatty liver disease in older adult patients

Year 2024, Volume: 15 Issue: 1, 23 - 27, 28.03.2024

Güner Kılıç , Gulce Ecem Kilic , Şevki Konür , Adnan Ozkahraman , Yusuf Kayar

https://doi.org/10.18663/tjcl.1317042

Abstract

Aim: The aim of this study was to show the effect of H. pylori eradication on the eradication of non-alcoholic fatty liver disease (NAFLD) in the older adult population.
Material and Methods: The patients included in the study were separated into two groups as the older adult group aged ≥65 years and the young adult group aged <65 years. Treatment of gemifloxacin 320mg/day, amoxicillin 2 gr/day, and rabeprazole 40 mg/day was administered to all the patients for the eradication of H.pylori. Hepatic steatosis was evaluated with hepatobiliary ultrasonography and was classified as grade 1, 2, or 3.
Results: Evaluation was made of 271 patients who were determined endoscopically and histopathologically with HP infection and treated accordingly. Successful HP eradication was achieved in 54 (79.4%) patients in the older adult group. In the examination of the relationship between fatty liver and HP eradication after treatment in the older age group, no significant relationship was observed between the presence of hepatosteatosis and HP eradication (p>0.05)
Conclusion: The known relationship between NAFLD and HP is of greater importance in patients of advanced age

Keywords

Helicobacter pylori, non-alcoholic fatty liver, older adult

Supporting Institution

yok

Project Number

-

Yaşlı erişkin hastalarda Helicobacter pylori eradikasyon başarısı ile non-alkolik yağlı karaciğer hastalığı arasındaki ilişki

Abstract

Amaç: Bu çalışmanın amacı yaşlı erişkin popülasyonda H. pylori eradikasyonunun non-alkolik yağlı karaciğer hastalığı ( NAYKH) eradikasyonu üzerindeki etkisini göstermekti.
Gereç ve Yöntemler: Çalışmaya alınan hastalar 65 yaş ve üstü yaşlı erişkin grubu ve 65 yaş altı genç erişkin grubu olarak iki gruba ayrıldı. H.pylori eradikasyonu için tüm hastalara gemifloksasin 320mg/gün, amoksisilin 2 gr/gün ve rabeprazol 40 mg/gün tedavisi uygulandı. Karaciğer yağlanması hepatobiliyer ultrasonografi ile değerlendirildi ve derece 1, 2 veya 3 olarak sınıflandırıldı.
Bulgular: Endoskopik ve histopatolojik olarak HP enfeksiyonu saptanan ve tedavi edilen 271 hasta değerlendirmeye alındı. Yaşlı erişkin grupta 54 (%79.4) hastada başarılı HP eradikasyonu sağlandı.İleri yaş grubunda karaciğer yağlanması varlığı ile HP eradikasyonu başarısı arasında istatistiki olarak anlamlı bir ilişki gözlenmedi (p>0,05)
Sonuç: NAYKH ve HP arasındaki bilinen ilişki ileri yaştaki hastalarda daha fazla önem taşımaktadır.

Keywords

Helicobacter pylori, non-alkolik yağlı karaciğer, yaşlı erişkin

Project Number

-

References

• Younossi ZM. Non-alcoholic fatty liver disease–a global public health perspective. Journal of hepatology. 2019;70(3):531-44.
• Değertekin, Bülent, et al. "The changing prevalence of non-alcoholic fatty liver disease (NAFLD) in Turkey in the last decade." The Turkish Journal of Gastroenterology 32.3 (2021): 302.
• Buzzetti E, Pinzani M, Tsochatzis EA. The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). Metabolism. 2016;65(8):1038-48.
• Larter CZ, Chitturi S, Heydet D, Farrell GC. A fresh look at NASH pathogenesis. Part 1: the metabolic movers. Journal of gastroenterology and hepatology. 2010;25(4):672-90.
• Argo CK, Caldwell SH. Epidemiology and natural history of non-alcoholic steatohepatitis. Clinics in liver disease. 2009;13(4):511-31.
• Okanoue T, Umemura A, Yasui K, Itoh Y. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in Japan. Journal of gastroenterology and hepatology. 2011;26:153-62.
• Hashimoto E, Tokushige K. Prevalence, gender, ethnic variations, and prognosis of NASH. Journal of gastroenterology. 2011;46:63-9.
• Francois F, Roper J, Joseph N, Pei Z, Chhada A, Shak JR, et al. The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin. BMC gastroenterology. 2011;11:1-9.
• Abo-Amer YE-E, Sabal A, Ahmed R, Hasan NFE, Refaie R, Mostafa SM, et al. Relationship between Helicobacter pylori infection and nonalcoholic fatty liver disease (NAFLD) in a developing country: a cross-sectional study. Diabetes, metabolic syndrome and obesity: targets and therapy. 2020;13:619.
• Polyzos SA, Kountouras J, Papatheodorou A, Patsiaoura K, Katsiki E, Zafeiriadou E, et al. Helicobacter pylori infection in patients with nonalcoholic fatty liver disease. Metabolism. 2013;62(1):121-6.
• Polyzos SA, Kountouras J, Zavos C, Deretzi G. The association between Helicobacter pylori infection and insulin resistance: a systematic review. Helicobacter. 2011;16(2):79-88.
• Buzás GM. Helicobacter pylori and non-alcoholic fatty liver disease. Minerva Gastroenterologica e Dietologica. 2020;66(3):267-79.
• Tanaka I, Ono S, Shimoda Y, Inoue M, Kinowaki S, Tsuda M, et al. Eradication of Helicobacter pylori may improve dyspepsia in the elderly for the long term. BMC gastroenterology. 2021;21:1-8.
• Heydari, Keyvan, et al. "Helicobacter pylori infection and non-alcoholic fatty liver disease: a systematic review and meta-analysis." The Turkish Journal of Gastroenterology 33.3 (2022): 171.
• do Nascimento JHR, Epifanio M, Soder RB, Baldisserotto M. MRI-diagnosed nonalcoholic fatty liver disease is correlated to insulin resistance in adolescents. Academic Radiology. 2013;20(11):1436-42.