The relationship between optic nerve sheath diameter and demographic and clinical findings in patients diagnosed with clinically isolated syndrome

Year 2024, Volume: 15 Issue: 3, 435 - 441, 30.09.2024

İbrahim Acır , Burcu Yüksel , Aysun Soysal , Vildan Yayla

https://doi.org/10.18663/tjcl.1549222

Abstract

Aim: This study aimed to assess optic nerve sheath diameter (ONSD) levels in patients diagnosed with clinically isolated syndrome (CIS) who were being followed in the demyelinating diseases clinic, as well as to examine their relationship with demographic characteristics and clinical findings.
Material and Methods: In this cross-sectional prospective study, 14 patients diagnosed with CIS who underwent lumbar puncture for specific cerebrospinal fluid (CSF) analysis were included between January 2024 and August 2024. The ONSD were measured by transorbital sonography. All patients' demographic characteristics, clinical parameters (CSF protein, CSF albumin, serum albumin, immunoglobulin G index, and vitamin D) were recorded.
Results: The patients had a mean age of 39.4 ± 12.8 years, and the majority were women. Oligoclonal bands were positive in all patients. The mean disease duration was 23.5 ± 7.6 days. The ONSD measurements for all patients ranged between 3.1 and 5.9 mm in the sagittal and axial planes of both eyes. There was a strong negative correlation between ONSD levels and age, diseases duration, CSF protein, CSF albumin, serum albumin, and immunoglobulin G index.
Conclusion: This study demonstrated a significant relationship between ONSD and various clinical and laboratory parameters in patients diagnosed with CIS. These findings suggest that ONSD may serve as a valuable, non-invasive marker in assessing disease severity and progression in CIS patients.

Keywords

axonal degeneration, clinically isolated syndrome, demyelinating diseases, multiple sclerosis, optic nerve sheath diameter, transorbital sonography

Klinik izole sendromlu hastalarda optik sinir kılıfı çapının demografik ve klinik bulgularla ilişkisi

Abstract

Amaç: Bu çalışma, demiyelinizan hastalıklar polikliniğinde takip edilen ve klinik izole sendrom (KİS) tanısı alan hastalarda optik sinir kılıfı çapı (OSKÇ) seviyelerini değerlendirmeyi ve bu seviyelerin demografik özellikler ve klinik bulgular ile ilişkisini incelemeyi amaçladı.
Gereç ve Yöntemler: Bu kesitsel prospektif çalışmaya, Ocak 2024 ile Ağustos 2024 tarihleri arasında spesifik beyin omurilik sıvısı (BOS) analizi için lomber ponksiyon uygulanan CIS tanısı almış 14 hasta dahil edildi. OSKÇ, transorbital sonografi ile ölçüldü. Tüm hastaların demografik özellikleri, klinik parametreleri (BOS proteini, BOS albümini, serum albümini, immünoglobulin G indeksi ve D vitamini) kaydedildi.
Bulgular: Hastaların ortalama yaşı 39,4 ± 12,8 yıl ve büyük çoğunluğu kadındı. Tüm hastalarda oligoklonal bantlar pozitif saptandı. Ortalama hastalık süresi 23,5 ± 7,6 gündü. Tüm hastalarda OSKÇ ölçümleri, her iki gözde de sagittal ve aksiyel düzlemlerde 3,1 - 5,9 mm arasında idi. OSKÇ ile yaş, hastalık süresi, BOS proteini, BOS albümini, serum albümini ve immünoglobulin G indeksi arasında güçlü bir negatif korelasyon saptandı.
Sonuçlar: Bu çalışma, KİS tanısı almış hastalarda OSKÇ ile çeşitli klinik ve laboratuvar parametreleri arasında anlamlı bir ilişki olduğunu göstermiştir. Bu bulgular, OSKÇ, KİS hastalarında hastalık şiddetini ve ilerlemesini değerlendirmede değerli ve non-invaziv bir biyomarker olarak kullanılabileceğini düşündürmektedir.

Keywords

aksonal dejenerasyon, klinik izole sendrom, demiyelinizan hastalıklar, multipl skleroz, optik sinir kılıfı çapı, transorbital sonografi

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