Marginal zone lymphoma presenting in a patient with autoimmune hemolytic anemia: a case report

Year 2022, , 80 - 82, 29.04.2022

Büşra Güner , Bedrettin Orhan , Tuba Ersal , Vildan Ozkocaman , Rıdvan Ali , Fahir Özkalemkaş

https://doi.org/10.46310/tjim.904114

Abstract

While autoimmune hemolytic anemia (AIHA) is expected in non-Hodgkin’s lymphomas, it is less common in marginal zone lymphoma. Sixty-year-old male patient was followed up with hemolytic anemia in our clinic and while the etiology was investigated, scattered nodes in the mediastinum and abdomen compatible with lymphoproliferative disease were observed on CT, and positive detection of CD5, CD19, CD20, CD22, CD45, HLA-DR, FMC-7 on flow cytometry sent from peripheral blood and a diagnosis of low grade B cell lymphoma (MZL) was made with the result of bone marrow pathology. We found it appropriate to present our MZL case because of its response to steroid treatment and its rare presentation with AIHA.

Keywords

AUTOIMMUNE HEMOLITHIC ANEMIA, MARGINAL ZONE LYMPHOMA, LYMPHOMA

References

• Barcellini W, Zaninoni A, Giannotta JA, Fattizzo B. New Insights in Autoimmune Hemolytic Anemia: From Pathogenesis to Therapy Stage 1. J Clin Med. 2020 Nov 27;9(12):3859. doi: 10.3390/jcm9123859.
• Zhou J-C, Wu M-Q, Peng Z-M, Zhao W-H, Bai Z-J. Clinical analysis of 20 patients with non-Hodgkin lymphoma and autoimmune hemolytic anemia: A retrospective study. Medicine (Baltimore). 2020 Feb;99(7):e19015. doi: 10.1097/ MD.0000000000019015.
• Doni E, Carli G, Di Rocco A, Sassone M, Gandolfi S, Patti C, Falisi E, Salemi C, Visco C. Autoimmune haemolytic anaemia in mantle cell lymphoma : an insidious complication associated with leukemic disease. Hematol Oncol. 2017 Mar;35(1):135-7. doi: 10.1002/hon.2241.
• Sindel A, Al-Juhaishi T, Yazbeck V. Marginal zone lymphoma: State-of-the-art treatment. Curr Treat Options Oncol. 2019 Dec 5;20(12):90. doi:10.1007/s11864-019-0687-5.
• Voinchet H, Etienne G, Ghiringelli CB, Pellegrin JL, Viallard JF, Parrens M, Longy-Boursier M. Splenic marginal zone lymphoma and autoimmunity: report of six cases. Rev Med Interne. 2010 Jan;31(1):4-11 (in French). doi: 10.1016/j. revmed.2009.05.003.
• Piris MA, Arribas A, Mollejo M. Marginal zone lymphoma. Semin Diagn Pathol. 2011 May;28(2):135-45. doi: 10.1053/j. semdp.2011.03.001.
• Hauswirth AW, Skrabs C, Schützinger C, Gaiger A, Lechner K, Jäger U. Autoimmune hemolytic anemias, Evans’ syndromes, and pure red cell aplasia in non-Hodgkin lymphomas. Leuk Lymphoma. 2007Jun;48(6):1139-49. doi: 10.1080/10428190701385173.