Severe hypertriglyceridemia is defined as serum triglyceride levels of 1000 mg/dL and more. Acute pancreatitis and fetal losses can be observed in association with severely high triglyceride levels during pregnancy.
Here we report the management of a 28-year-old pregnant woman with very severe HTG with the data in the literature.
Berglund L, Brunzell JD, Goldberg AC, et al. Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline [published correction appears in J Clin Endocrinol Metab. 2015 Dec;100(12):4685]. J Clin Endocrinol Metab. 2012;97(9):2969-2989. doi:10.1210/jc.2011-3213
Fan W, Philip S, Granowitz C, Toth PP, Wong ND. Hypertriglyceridemia in statin-treated US adults: the National Health and Nutrition Examination Survey. J Clin Lipidol. 2019;13(1):100-108. doi:10.1016/j.jacl.2018.11.008
Scherer J, Singh VP, Pitchumoni CS, Yadav D. Issues in hypertriglyceridemic pancreatitis: an update. J Clin Gastroenterol. 2014;48(3):195-203. doi:10.1097/01.mcg.0000436438.60145.5a
Ghio A, Bertolotto A, Resi V, Volpe L, Di Cianni G. Triglyceride metabolism in pregnancy. Adv Clin Chem. 2011;55:133-153. doi:10.1016/b978-0-12-387042-1.00007-1
Saadi HF, Kurlander DJ, Erkins JM, Hoogwerf BJ. Severe hypertriglyceridemia and acute pancreatitis during pregnancy: treatment with gemfibrozil. Endocr Pract. 1999;5(1):33-36. doi:10.4158/EP.5.1.33
Zhu Y, Pan X, Zeng H, et al. A Study on the Etiology, Severity, and Mortality of 3260 Patients With Acute Pancreatitis According to the Revised Atlanta Classification in Jiangxi, China Over an 8-Year Period. Pancreas. 2017;46(4):504-509. doi:10.1097/MPA.0000000000000776
Kleess LE, Janicic N. SEVERE HYPERTRIGLYCERIDEMIA IN PREGNANCY: A CASE REPORT AND REVIEW OF THE LITERATURE. AACE Clin Case Rep. 2018;5(2):e99-e103. Published 2018 Oct 5. doi:10.4158/ACCR-2018-0168
Alyse S. Goldberg, Robert A. Hegele, Severe Hypertriglyceridemia in Pregnancy, The Journal of Clinical Endocrinology & Metabolism, Volume 97, Issue 8, 1 August 2012, Pages 2589–2596, https://doi.org/10.1210/jc.2012-1250
Newman CB, Blaha MJ, Boord JB, et al. Lipid Management in Patients with Endocrine Disorders: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2020;105(12):dgaa674. doi:10.1210/clinem/dgaa674
Berglund L, Brunzell JD, Goldberg AC, et al. Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline [published correction appears in J Clin Endocrinol Metab. 2015 Dec;100(12):4685]. J Clin Endocrinol Metab. 2012;97(9):2969-2989. doi:10.1210/jc.2011-3213
Fan W, Philip S, Granowitz C, Toth PP, Wong ND. Hypertriglyceridemia in statin-treated US adults: the National Health and Nutrition Examination Survey. J Clin Lipidol. 2019;13(1):100-108. doi:10.1016/j.jacl.2018.11.008
Scherer J, Singh VP, Pitchumoni CS, Yadav D. Issues in hypertriglyceridemic pancreatitis: an update. J Clin Gastroenterol. 2014;48(3):195-203. doi:10.1097/01.mcg.0000436438.60145.5a
Ghio A, Bertolotto A, Resi V, Volpe L, Di Cianni G. Triglyceride metabolism in pregnancy. Adv Clin Chem. 2011;55:133-153. doi:10.1016/b978-0-12-387042-1.00007-1
Saadi HF, Kurlander DJ, Erkins JM, Hoogwerf BJ. Severe hypertriglyceridemia and acute pancreatitis during pregnancy: treatment with gemfibrozil. Endocr Pract. 1999;5(1):33-36. doi:10.4158/EP.5.1.33
Zhu Y, Pan X, Zeng H, et al. A Study on the Etiology, Severity, and Mortality of 3260 Patients With Acute Pancreatitis According to the Revised Atlanta Classification in Jiangxi, China Over an 8-Year Period. Pancreas. 2017;46(4):504-509. doi:10.1097/MPA.0000000000000776
Kleess LE, Janicic N. SEVERE HYPERTRIGLYCERIDEMIA IN PREGNANCY: A CASE REPORT AND REVIEW OF THE LITERATURE. AACE Clin Case Rep. 2018;5(2):e99-e103. Published 2018 Oct 5. doi:10.4158/ACCR-2018-0168
Alyse S. Goldberg, Robert A. Hegele, Severe Hypertriglyceridemia in Pregnancy, The Journal of Clinical Endocrinology & Metabolism, Volume 97, Issue 8, 1 August 2012, Pages 2589–2596, https://doi.org/10.1210/jc.2012-1250
Newman CB, Blaha MJ, Boord JB, et al. Lipid Management in Patients with Endocrine Disorders: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2020;105(12):dgaa674. doi:10.1210/clinem/dgaa674
Satı Burcu Çetin
ULUDAG UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE0000-0003-3760-6017Türkiye
Yasemin Aydoğan Ünsal
ULUDAG UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, ENDOCRINOLOGY AND METABOLIC DISEASES0000-0002-1566-3099Türkiye
Coşkun Ateş
ULUDAG UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, ENDOCRINOLOGY AND METABOLIC DISEASES0000-0003-4565-9848Türkiye
Soner Cander
ULUDAG UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, ENDOCRINOLOGY AND METABOLIC DISEASES0000-0001-6303-7896Türkiye
Özen Öz Gül
ULUDAG UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, ENDOCRINOLOGY AND METABOLIC DISEASES0000-0002-1332-4165Türkiye
Erdinç Ertürk
ULUDAG UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, ENDOCRINOLOGY AND METABOLIC DISEASES0000-0003-2399-6608Türkiye
Canan Ersoy
ULUDAG UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, ENDOCRINOLOGY AND METABOLIC DISEASES0000-0003-4510-6282Türkiye
Aydemir E, Çetin SB, Aydoğan Ünsal Y, Ateş C, Cander S, Öz Gül Ö, Ertürk E, Ersoy C (March 1, 2021) A Case of very Severe Hypertriglyceridemia during Pregnancy. Turkish Journal of Internal Medicine 3 Supplement 1 94–95.
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