A Case of Acute Lymphoblastic Leukemia Complicated with Sinonasal Mucormycosis Infection

Year 2024, Volume: 6 Issue: 1, 64 - 68, 29.01.2024

Asuman Şebnem Hacımustafaoğlu , Bedrettin Orhan , Tuba Ersal , Vildan Ozkocaman , Fahir Özkalemkaş

https://doi.org/10.46310/tjim.1316471

Abstract

Acute lymphoblastic leukemia (ALL) is an aggressive hematologic malignancy of lymphoid progenitor cells. During treatment of ALL, the patients may be complicated by fatal infections such as sinonasal mucormycosis. In patients with immunocompromised conditions like haematologic malignancies, mucormycosis can be deadly. Once mucormycosis has been detected, it is critical to act quickly to begin treatment. Amphotericin B, posaconazole, or isavuconazole are the medications of choice. Effective treatment requires a long-term course of therapy. Switching to other effective medications should be considered when the preferred treatment is not working. The factors contributing to mucormycosis must also be treated, such as the underlying conditions (haematologic malignancies). Herein, we aimed to discuss a clinically stable ALL patient complicated with extensive sinonasal mucormycosis. She improved with amphotericin B (5 mg/kg/day) and oral posaconazol (300 mg/day) treatment.

Keywords

acute lymphoblastic leukemia, mucormycosis, sinonasal mucormycosis, Amphoteracin B, posaconazol

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