Higenamine decreases testicular damage injured by ischemia reperfusion: A biochemical study

Ömer Topdağı; Ayhan Tanyeli; Fazile Nur Ekinci Akdemir; Derya Güzel Erdoğan; Mustafa Can Güler; Ersen Eraslan

Research Article

Higenamine decreases testicular damage injured by ischemia reperfusion: A biochemical study

Year 2019, Volume: 4 Issue: 2, 92 - 99, 28.10.2019

Ömer Topdağı , Ayhan Tanyeli , Fazile Nur Ekinci Akdemir , Derya Güzel Erdoğan , Mustafa Can Güler , Ersen Eraslan

Abstract

Purpose:The purpose of this research is to examine protective effects of Higenamine on testis injured by the ischemia reperfusion.

Material and Method:In our experiment, the rats were separated as 3 groups including sham, control, ischemia reperfusion, and ischemia reperfusion+higenamine. Some oxidant, antioxidant and inflammatory parameters were evaluated in testis tissues obtained at the end of the experiment.

Findings: In current study, we observed that the oxidant and inflammatory parameters increased and antioxidant parameters decreased in the ischemia reperfusion group but the antioxidant parameters increased and oxidant parameters decreased in treatment group suggesting that single dose administration of higenamine is protective against testicular oxidative damage resulted from ischemia reperfusion

Keywords

Ischemia reperfusion; higenamine; testis; oxidative stress; inflammation; rat.

References

1. Cuckow PM, Frank JD. 2000. Torsion of the testis. BJU international 86:349-53
2. Etensel B, Ozkisacik S, Ozkara E, Karul A, Oztan O, et al. 2007. Dexpanthenol attenuates lipid peroxidation and testicular damage at experimental ischemia and reperfusion injury. Pediatric surgery international 23:177-81
3. Power RE, Scanlon R, Kay EW, Creagh TA, Bouchier-Hayes DJ. 2003. Long-term protective effects of hypothermia on reperfusion injury post-testicular torsion. Scandinavian journal of urology and nephrology 37:456-60
4. Visser AJ, Heyns CF. 2003. Testicular function after torsion of the spermatic cord. BJU international 92:200-3
5. Filho DW, Torres MA, Bordin AL, Crezcynski-Pasa TB, Boveris A. 2004. Spermatic cord torsion, reactive oxygen and nitrogen species and ischemia-reperfusion injury. Molecular aspects of medicine 25:199-210
6. Pham-Huy LA, He H, Pham-Huy C. 2008. Free radicals, antioxidants in disease and health. International journal of biomedical science : IJBS 4:89-96
7. Sharma RK, Pasqualotto FF, Nelson DR, Thomas AJ, Jr., Agarwal A. 1999. The reactive oxygen species-total antioxidant capacity score is a new measure of oxidative stress to predict male infertility. Human reproduction (Oxford, England) 14:2801-7
8. Sarica K, Bakir K, Yagci F, Erbagci A, Topcu O, Uysal O. 1999. Unilateral testicular torsion: protective effect of verapamil on contralateral testicular histology. Urologia internationalis 62:159-63
9. Cay A, Alver A, Kucuk M, Isik O, Eminagaoglu MS, et al. 2006. The effects of N-acetylcysteine on antioxidant enzyme activities in experimental testicular torsion. The Journal of surgical research 131:199-203
10. Kosuge T, Yokota M. 1976. Letter: Studies on cardiac principle of aconite root. Chemical & pharmaceutical bulletin 24:176-8
11. Zhang N, Lian Z, Peng X, Li Z, Zhu H. 2017. Applications of Higenamine in pharmacology and medicine. Journal of ethnopharmacology 196:242-52
12. Li X, Tian Y, Wang T, Lin Q, Feng X, et al. 2017. Role of the p-Coumaroyl Moiety in the Antioxidant and Cytoprotective Effects of Flavonoid Glycosides: Comparison of Astragalin and Tiliroside. Molecules (Basel, Switzerland) 22
13. Wang X, Li X, Jingfen W, Fei D, Mei P. 2019. Higenamine alleviates cerebral ischemia-reperfusion injury in rats. Frontiers in bioscience (Landmark edition) 24:859-69
14. Singhuber J, Zhu M, Prinz S, Kopp B. 2009. Aconitum in traditional Chinese medicine: a valuable drug or an unpredictable risk? Journal of ethnopharmacology 126:18-30
15. Ohkawa H, Ohishi N, Yagi K. 1979. Assay for Lipid Peroxides in Animal-Tissues by Thiobarbituric Acid Reaction. Anal Biochem 95:351-8
16. Harma M, Harma M, Kocyigit A, Erel O. 2005. Increased DNA damage in patients with complete hydatidiform mole. Mutat Res-Gen Tox En 583:49-54
17. Bradley PP, Priebat DA, Christensen RD, Rothstein G. 1982. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 78:206-9
18. Sun Y, Oberley LW, Li Y. 1988. A Simple Method for Clinical Assay of Superoxide-Dismutase. Clin Chem 34:497-500
19. Pogorelic Z, Mustapic K, Jukic M, Todoric J, Mrklic I, et al. 2016. Management of acute scrotum in children: a 25-year single center experience on 558 pediatric patients. The Canadian journal of urology 23:8594-601
20. Wei SM, Yan ZZ, Zhou J. 2011. Protective effect of rutin on testicular ischemia-reperfusion injury. Journal of pediatric surgery 46:1419-24
21. Kalogeris T, Baines CP, Krenz M, Korthuis RJ. 2012. Cell biology of ischemia/reperfusion injury. International review of cell and molecular biology 298:229-317
22. Yapca OE, Borekci B, Suleyman H. 2013. Ischemia-reperfusion damage. The Eurasian journal of medicine 45:126-7
23. Mogilner JG, Elenberg Y, Lurie M, Shiloni E, Coran AG, Sukhotnik I. 2006. Effect of dexamethasone on germ cell apoptosis in the contralateral testis after testicular ischemia-reperfusion injury in the rat. Fertility and sterility 85 Suppl 1:1111-7
24. Kandhare AD, Mukherjee A, Bodhankar SL. 2017. Antioxidant for treatment of diabetic nephropathy: A systematic review and meta-analysis. Chemico-biological interactions 278:212-21
25. Snoeijs MG, van Heurn LW, Buurman WA. 2010. Biological modulation of renal ischemia-reperfusion injury. Current opinion in organ transplantation 15:190-926. Sies H. 2015. Oxidative stress: a concept in redox biology and medicine. Redox biology 4:180-3
27. Teugwa CM, Mejiato PC, Zofou D, Tchinda BT, Boyom FF. 2013. Antioxidant and antidiabetic profiles of two African medicinal plants: Picralima nitida (Apocynaceae) and Sonchus oleraceus (Asteraceae). BMC complementary and alternative medicine 13:175
28. Yin M, Wheeler MD, Connor HD, Zhong Z, Bunzendahl H, et al. 2001. Cu/Zn-superoxide dismutase gene attenuates ischemia-reperfusion injury in the rat kidney. Journal of the American Society of Nephrology : JASN 12:2691-700
29. Cakir M, Duzova H, Taslidere A, Orhan G, Ozyalin F. 2017. Protective effects of salusin-alpha and salusin-beta on renal ischemia/reperfusion damage and their levels in ischemic acute renal failure. Biotechnic & histochemistry : official publication of the Biological Stain Commission 92:122-33
30. Senbel AM, AbdelMoneim L, Omar AG. 2014. Celecoxib modulates nitric oxide and reactive oxygen species in kidney ischemia/reperfusion injury and rat aorta model of hypoxia/reoxygenation. Vascular pharmacology 62:24-31
31. Rabus M, Demirbag R, Sezen Y, Konukoglu O, Yildiz A, et al. 2008. Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 36:536-40
32. Erel O. 2005. A new automated colorimetric method for measuring total oxidant status. Clinical biochemistry 38:1103-11
33. Yazici S, Demirtas S, Guclu O, Karahan O, Yavuz C, et al. 2014. Using oxidant and antioxidant levels to predict the duration of both acute peripheral and mesenteric ischemia. Perfusion 29:450-5
34. Yurtcu E, Togrul C, Ozyer S, Uzunlar O, Karatas YH, et al. 2015. Dose dependent protective effects of vardenafil on ischemia–reperfusion injury with biochemical and histopathologic evaluation in rat ovary. J Pediatr Surg 50:1205-9
35. Chen YL, Zhuang XD, Xu ZW, Lu LH, Guo HL, et al. 2013. Higenamine Combined with [6]-Gingerol Suppresses Doxorubicin-Triggered Oxidative Stress and Apoptosis in Cardiomyocytes via Upregulation of PI3K/Akt Pathway. Evidence-based complementary and alternative medicine : eCAM 2013:970490
36. Duan W, Chen J, Wu Y, Zhang Y, Xu Y. 2016. Protective effect of higenamine ameliorates collagen-induced arthritis through heme oxygenase-1 and PI3K/Akt/Nrf-2 signaling pathways. Experimental and therapeutic medicine 12:3107-12
37. White BC, Grossman LI, Krause GS. 1993. Brain injury by global ischemia and reperfusion: a theoretical perspective on membrane damage and repair. Neurology 43:1656-65
38. Akdemir A, Erbas O, Ergenoglu M, Ozgur Yeniel A, Oltulu F, et al. 2014. Montelukast prevents ischaemia/reperfusion-induced ovarian damage in rats. European journal of obstetrics, gynecology, and reproductive biology 173:71-6
39. Erkanli Senturk G, Erkanli K, Aydin U, Yucel D, Isiksacan N, et al. 2013. The protective effect of oxytocin on ischemia/reperfusion injury in rat urinary bladder. Peptides 40:82-8
40. Niki E, Yoshida Y, Saito Y, Noguchi N. 2005. Lipid peroxidation: mechanisms, inhibition, and biological effects. Biochemical and biophysical research communications 338:668-76
41. Ximenes VF, Paino IM, Faria-Oliveira OM, Fonseca LM, Brunetti IL. 2005. Indole ring oxidation by activated leukocytes prevents the production of hypochlorous acid. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 38:1575-83
42. Zhang Y, Zhu J, Guo L, Zou Y, Wang F, et al. 2017. Cholecystokinin protects mouse liver against ischemia and reperfusion injury. International immunopharmacology 48:180-6
43. Liu C, Zhu C, Wang G, Xu R, Zhu Y. 2015. Higenamine regulates Nrf2-HO-1-Hmgb1 axis and attenuates intestinal ischemia-reperfusion injury in mice. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 64:395-403

Year 2019, Volume: 4 Issue: 2, 92 - 99, 28.10.2019

Ömer Topdağı , Ayhan Tanyeli , Fazile Nur Ekinci Akdemir , Derya Güzel Erdoğan , Mustafa Can Güler , Ersen Eraslan

Abstract

References

1. Cuckow PM, Frank JD. 2000. Torsion of the testis. BJU international 86:349-53
2. Etensel B, Ozkisacik S, Ozkara E, Karul A, Oztan O, et al. 2007. Dexpanthenol attenuates lipid peroxidation and testicular damage at experimental ischemia and reperfusion injury. Pediatric surgery international 23:177-81
3. Power RE, Scanlon R, Kay EW, Creagh TA, Bouchier-Hayes DJ. 2003. Long-term protective effects of hypothermia on reperfusion injury post-testicular torsion. Scandinavian journal of urology and nephrology 37:456-60
4. Visser AJ, Heyns CF. 2003. Testicular function after torsion of the spermatic cord. BJU international 92:200-3
5. Filho DW, Torres MA, Bordin AL, Crezcynski-Pasa TB, Boveris A. 2004. Spermatic cord torsion, reactive oxygen and nitrogen species and ischemia-reperfusion injury. Molecular aspects of medicine 25:199-210
6. Pham-Huy LA, He H, Pham-Huy C. 2008. Free radicals, antioxidants in disease and health. International journal of biomedical science : IJBS 4:89-96
7. Sharma RK, Pasqualotto FF, Nelson DR, Thomas AJ, Jr., Agarwal A. 1999. The reactive oxygen species-total antioxidant capacity score is a new measure of oxidative stress to predict male infertility. Human reproduction (Oxford, England) 14:2801-7
8. Sarica K, Bakir K, Yagci F, Erbagci A, Topcu O, Uysal O. 1999. Unilateral testicular torsion: protective effect of verapamil on contralateral testicular histology. Urologia internationalis 62:159-63
9. Cay A, Alver A, Kucuk M, Isik O, Eminagaoglu MS, et al. 2006. The effects of N-acetylcysteine on antioxidant enzyme activities in experimental testicular torsion. The Journal of surgical research 131:199-203
10. Kosuge T, Yokota M. 1976. Letter: Studies on cardiac principle of aconite root. Chemical & pharmaceutical bulletin 24:176-8
11. Zhang N, Lian Z, Peng X, Li Z, Zhu H. 2017. Applications of Higenamine in pharmacology and medicine. Journal of ethnopharmacology 196:242-52
12. Li X, Tian Y, Wang T, Lin Q, Feng X, et al. 2017. Role of the p-Coumaroyl Moiety in the Antioxidant and Cytoprotective Effects of Flavonoid Glycosides: Comparison of Astragalin and Tiliroside. Molecules (Basel, Switzerland) 22
13. Wang X, Li X, Jingfen W, Fei D, Mei P. 2019. Higenamine alleviates cerebral ischemia-reperfusion injury in rats. Frontiers in bioscience (Landmark edition) 24:859-69
14. Singhuber J, Zhu M, Prinz S, Kopp B. 2009. Aconitum in traditional Chinese medicine: a valuable drug or an unpredictable risk? Journal of ethnopharmacology 126:18-30
15. Ohkawa H, Ohishi N, Yagi K. 1979. Assay for Lipid Peroxides in Animal-Tissues by Thiobarbituric Acid Reaction. Anal Biochem 95:351-8
16. Harma M, Harma M, Kocyigit A, Erel O. 2005. Increased DNA damage in patients with complete hydatidiform mole. Mutat Res-Gen Tox En 583:49-54
17. Bradley PP, Priebat DA, Christensen RD, Rothstein G. 1982. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 78:206-9
18. Sun Y, Oberley LW, Li Y. 1988. A Simple Method for Clinical Assay of Superoxide-Dismutase. Clin Chem 34:497-500
19. Pogorelic Z, Mustapic K, Jukic M, Todoric J, Mrklic I, et al. 2016. Management of acute scrotum in children: a 25-year single center experience on 558 pediatric patients. The Canadian journal of urology 23:8594-601
20. Wei SM, Yan ZZ, Zhou J. 2011. Protective effect of rutin on testicular ischemia-reperfusion injury. Journal of pediatric surgery 46:1419-24
21. Kalogeris T, Baines CP, Krenz M, Korthuis RJ. 2012. Cell biology of ischemia/reperfusion injury. International review of cell and molecular biology 298:229-317
22. Yapca OE, Borekci B, Suleyman H. 2013. Ischemia-reperfusion damage. The Eurasian journal of medicine 45:126-7
23. Mogilner JG, Elenberg Y, Lurie M, Shiloni E, Coran AG, Sukhotnik I. 2006. Effect of dexamethasone on germ cell apoptosis in the contralateral testis after testicular ischemia-reperfusion injury in the rat. Fertility and sterility 85 Suppl 1:1111-7
24. Kandhare AD, Mukherjee A, Bodhankar SL. 2017. Antioxidant for treatment of diabetic nephropathy: A systematic review and meta-analysis. Chemico-biological interactions 278:212-21
25. Snoeijs MG, van Heurn LW, Buurman WA. 2010. Biological modulation of renal ischemia-reperfusion injury. Current opinion in organ transplantation 15:190-926. Sies H. 2015. Oxidative stress: a concept in redox biology and medicine. Redox biology 4:180-3
27. Teugwa CM, Mejiato PC, Zofou D, Tchinda BT, Boyom FF. 2013. Antioxidant and antidiabetic profiles of two African medicinal plants: Picralima nitida (Apocynaceae) and Sonchus oleraceus (Asteraceae). BMC complementary and alternative medicine 13:175
28. Yin M, Wheeler MD, Connor HD, Zhong Z, Bunzendahl H, et al. 2001. Cu/Zn-superoxide dismutase gene attenuates ischemia-reperfusion injury in the rat kidney. Journal of the American Society of Nephrology : JASN 12:2691-700
29. Cakir M, Duzova H, Taslidere A, Orhan G, Ozyalin F. 2017. Protective effects of salusin-alpha and salusin-beta on renal ischemia/reperfusion damage and their levels in ischemic acute renal failure. Biotechnic & histochemistry : official publication of the Biological Stain Commission 92:122-33
30. Senbel AM, AbdelMoneim L, Omar AG. 2014. Celecoxib modulates nitric oxide and reactive oxygen species in kidney ischemia/reperfusion injury and rat aorta model of hypoxia/reoxygenation. Vascular pharmacology 62:24-31
31. Rabus M, Demirbag R, Sezen Y, Konukoglu O, Yildiz A, et al. 2008. Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 36:536-40
32. Erel O. 2005. A new automated colorimetric method for measuring total oxidant status. Clinical biochemistry 38:1103-11
33. Yazici S, Demirtas S, Guclu O, Karahan O, Yavuz C, et al. 2014. Using oxidant and antioxidant levels to predict the duration of both acute peripheral and mesenteric ischemia. Perfusion 29:450-5
34. Yurtcu E, Togrul C, Ozyer S, Uzunlar O, Karatas YH, et al. 2015. Dose dependent protective effects of vardenafil on ischemia–reperfusion injury with biochemical and histopathologic evaluation in rat ovary. J Pediatr Surg 50:1205-9
35. Chen YL, Zhuang XD, Xu ZW, Lu LH, Guo HL, et al. 2013. Higenamine Combined with [6]-Gingerol Suppresses Doxorubicin-Triggered Oxidative Stress and Apoptosis in Cardiomyocytes via Upregulation of PI3K/Akt Pathway. Evidence-based complementary and alternative medicine : eCAM 2013:970490
36. Duan W, Chen J, Wu Y, Zhang Y, Xu Y. 2016. Protective effect of higenamine ameliorates collagen-induced arthritis through heme oxygenase-1 and PI3K/Akt/Nrf-2 signaling pathways. Experimental and therapeutic medicine 12:3107-12
37. White BC, Grossman LI, Krause GS. 1993. Brain injury by global ischemia and reperfusion: a theoretical perspective on membrane damage and repair. Neurology 43:1656-65
38. Akdemir A, Erbas O, Ergenoglu M, Ozgur Yeniel A, Oltulu F, et al. 2014. Montelukast prevents ischaemia/reperfusion-induced ovarian damage in rats. European journal of obstetrics, gynecology, and reproductive biology 173:71-6
39. Erkanli Senturk G, Erkanli K, Aydin U, Yucel D, Isiksacan N, et al. 2013. The protective effect of oxytocin on ischemia/reperfusion injury in rat urinary bladder. Peptides 40:82-8
40. Niki E, Yoshida Y, Saito Y, Noguchi N. 2005. Lipid peroxidation: mechanisms, inhibition, and biological effects. Biochemical and biophysical research communications 338:668-76
41. Ximenes VF, Paino IM, Faria-Oliveira OM, Fonseca LM, Brunetti IL. 2005. Indole ring oxidation by activated leukocytes prevents the production of hypochlorous acid. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 38:1575-83
42. Zhang Y, Zhu J, Guo L, Zou Y, Wang F, et al. 2017. Cholecystokinin protects mouse liver against ischemia and reperfusion injury. International immunopharmacology 48:180-6
43. Liu C, Zhu C, Wang G, Xu R, Zhu Y. 2015. Higenamine regulates Nrf2-HO-1-Hmgb1 axis and attenuates intestinal ischemia-reperfusion injury in mice. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 64:395-403

There are 42 citations in total.

Details

Primary Language	English
Journal Section	Volume IV, Issue II, 2019
Authors	Ömer Topdağı 0000-0002-9690-4447 Ayhan Tanyeli 0000-0002-0095-0917 Fazile Nur Ekinci Akdemir 0000-0001-9585-3169 Derya Güzel Erdoğan 0000-0002-7618-5043 Mustafa Can Güler 0000-0001-8588-1035 Ersen Eraslan 0000-0003-2424-2269
Publication Date	October 28, 2019
Published in Issue	Year 2019 Volume: 4 Issue: 2

Cite

APA	Topdağı, Ö., Tanyeli, A., Ekinci Akdemir, F. N., Güzel Erdoğan, D., et al. (2019). Higenamine decreases testicular damage injured by ischemia reperfusion: A biochemical study. Turkish Journal of Science, 4(2), 92-99.
AMA	Topdağı Ö, Tanyeli A, Ekinci Akdemir FN, Güzel Erdoğan D, Güler MC, Eraslan E. Higenamine decreases testicular damage injured by ischemia reperfusion: A biochemical study. TJOS. October 2019;4(2):92-99.
Chicago	Topdağı, Ömer, Ayhan Tanyeli, Fazile Nur Ekinci Akdemir, Derya Güzel Erdoğan, Mustafa Can Güler, and Ersen Eraslan. “Higenamine Decreases Testicular Damage Injured by Ischemia Reperfusion: A Biochemical Study”. Turkish Journal of Science 4, no. 2 (October 2019): 92-99.
EndNote	Topdağı Ö, Tanyeli A, Ekinci Akdemir FN, Güzel Erdoğan D, Güler MC, Eraslan E (October 1, 2019) Higenamine decreases testicular damage injured by ischemia reperfusion: A biochemical study. Turkish Journal of Science 4 2 92–99.
IEEE	Ö. Topdağı, A. Tanyeli, F. N. Ekinci Akdemir, D. Güzel Erdoğan, M. C. Güler, and E. Eraslan, “Higenamine decreases testicular damage injured by ischemia reperfusion: A biochemical study”, TJOS, vol. 4, no. 2, pp. 92–99, 2019.
ISNAD	Topdağı, Ömer et al. “Higenamine Decreases Testicular Damage Injured by Ischemia Reperfusion: A Biochemical Study”. Turkish Journal of Science 4/2 (October 2019), 92-99.
JAMA	Topdağı Ö, Tanyeli A, Ekinci Akdemir FN, Güzel Erdoğan D, Güler MC, Eraslan E. Higenamine decreases testicular damage injured by ischemia reperfusion: A biochemical study. TJOS. 2019;4:92–99.
MLA	Topdağı, Ömer et al. “Higenamine Decreases Testicular Damage Injured by Ischemia Reperfusion: A Biochemical Study”. Turkish Journal of Science, vol. 4, no. 2, 2019, pp. 92-99.
Vancouver	Topdağı Ö, Tanyeli A, Ekinci Akdemir FN, Güzel Erdoğan D, Güler MC, Eraslan E. Higenamine decreases testicular damage injured by ischemia reperfusion: A biochemical study. TJOS. 2019;4(2):92-9.

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