Glycated Hemoglobin (HbA1C): A Predictor of In-hospital Short Therm All Cause Mortality

Year 2020, Volume: 5 Issue: 1, 41 - 47, 30.03.2020

Ömer Topdağı , Yasemin Kaya , Oktay Gulcu , İbrahim Tanboğa , Nuri Bakan

Abstract

Background & objectives: HbA1c shows the mean glucose level in blood and is a biochemical parameter used in follow-up and diagnosis of diabetic patients. We aimed to investigate the association between HbA1c and in-hospital all cause mortality in diabetic patients who were admitted due to any diagnosis.
Methods: 3207 diabetic patients included study who had been diagnosed with diabetes mellitus. Trauma patients, type 1 diabetes were excluded. Patients’ age, gender, admission diagnosis, duration of hospitalization, whether they died in-hospital, laboratory parameters and HbA1c levels were recorded.
Results: The mean age of patients was 50.53±17 years with 59.7% (n:1913) being females. Patients who died in hospital had higher HbA1c, age, BUN (blood urea nitrogen), creatine and uric acid levels according to the Univariate analysis (p=0.000, p=0.000; p=0.004, p=0.04, p=0.03; respectively). In the model 1 in multivariate analysis, there was a significant correlation between HbA1c level and in-hospital mortality (uncorrected OR: 1.216, 95% CI 1.116-1.326, p<0.001). In the model 2, the significant correlation between HbA1c level and in hospital mortality continued when corrected with age and gender (corrected OR: 1.150, 95% CI 1.046-1.265, p:0.004). In the model 3, which was created with covariates that were found significant in the univariate analysis, the correlation between HbA1c level and in hospital mortality still continued (corrected OR: 1.151, 95% CI 1.041-1.271, p:0.006).
Interpretation & conclusions: There was a positive correlation between in hospital all cause mortality and HbA1c level in diabetic patients who had admitted any diagnosis. HbA1c level predict in hospital short term all cause mortality.

Keywords

Tip 2 Diabetes Mellitus, HbA1c, In hospital mortality

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