The study of some hematologic and biochemical parameters in chickens vaccinated with inactivated dual Newcastle-Influenza vaccine

Year 2020, Volume: 4 Issue: 1, 17 - 22, 10.03.2020

Mehdi Ezdiyadi , Ali Akbar Abolfathi Aref Hoshyari Abolfazl Jafari-sales , Farhad Farhadi

Abstract

Results: The results showed that the values of biochemical parameters
such as albumin, glucose, total protein, triglyceride, cholesterol, ALT, AST,
and ALP enzymes, sodium and potassium minerals, and hematocrit and hemoglobin
levels in vaccinated and non-vaccinated chickens were not significantly
different. Also, in chickens injected with antigen, Newcastle disease and
influenza antibody titers were significantly different with those groups containing
adjuvant.

Materials and Methods: In this study, after subcutaneous and
intramuscular inoculation of inactivated dual oil emulsion Newcastle-Influenza vaccine,
the serum antibody level and hematobiochemical factors of these avian were analyzed
on 7, 14, 21, and 28 days after vaccine injection.

Objective: Newcastle and Influenza diseases are important viral
diseases and its occurrence and virulence in Iran has increased in recent
years. The purpose of this study was to evaluate the humoral immune responses
of chickens vaccinated with inactivated dual oil emulsion Newcastle disease and
avian influenza vaccine in two methods of intramuscular and subcutaneous
injection as well as to assess the possible changes in serum biochemical
factors.

Conclusion: The results of this study indicate that the
intramuscular and subcutaneous injection of dual combination vaccine is similar
in terms of changes in biochemical and hematological factors and Newcastle
disease and influenza antibody titers. To ensure safety in inactivated
vaccines, the presence of proper adjuvant is essential for immune response.

Keywords

Avian influenza virus, Newcastle virus, biochemical factors

References

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