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A Case Of Acute Coronary Syndrome After Splenectomy In An Idiopathic Thrombocytopenic Purpura Patient

Year 2016, Volume: 8 Issue: 2, 89 - 92, 24.07.2016

Abstract

Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disease characterised by decreased thrombocyte count due to antithrombocyte IgG production, increased megacaryocte count in bone marrow and decreased thrombocyte life span. Thrombocytes have a key role in pathogenesis of acute coronary syndrome. Size, density or activities of thrombocytes might trigger acute coronary syndrome. In this case report, we hope to attract attention to acute vascular complications that might develop after splenectomy, by reporting acute coronary syndrome developed in the 48 hours following splenectomy in an ITP patient,

Dr. Necla DERELİ
Dr. Zehra BAYKAL TUTAL
Dr. Esra ÖZAYAR
Dr. Mehtap KONCA
Dr. Mehmet ŞAHAP
Dr. Eyüp HORASANLI

References

  • 1. Önder A, Kapan M, Gül M, et al. Idiopa-tik trombositopenik purpuralı hastalarda splenektomi: 109 olgunun analizi. Dicle Medical Journal 2012;39:49-53.
  • 2. British Committee for Standarts in Haematology General Haematology Task Force. Guidelines for the investigation and management of idiopathic thrombocytopenic purpura in adults, children and in pregnancy. British Journal of Haematolgy 2003; 120 (4):574-96.
  • 3. Balague C, Targarona EM, Cerdan G, et al. Long-term outcome after lapatasco-pic splenectomy related to hematological diagnosis. Surgical Endoscopy 2004; 18:1283-7.
  • 4. Schwart J, Leber MD, Gillis S, Giunta A, Eldor A, Bussel JB. Long term follow up after splenectomy performed for immune thrombocytopenic purpura (ITP). American Journal Hematolgy 2003; 72:94-8.
  • 5. Vianelli N, Gali M, Vivo A, et al. Efficacy and safety of splenectomy in immune thrombocytopenic purpura: long term results of 402 cases. Haematologica 2005;90:72-7.
  • 6. Crary SE, Buchanan G. Vascular complications after splenectomy for hematologic disorders. Blood 2009;114:2861-8.
  • 7. Visudhiphan S, Ketsa-Ard K, Piankjia-gum A, Tumliang S. Blood coagulation and platelet profiles in persistant postsplenectomy thrombocytosis: the relationship to thromboembolism. Biomed Pharmacother 1985;39:264-71.
  • 8. Aviram M, Brook JG, Tatarsky I, Levy Y, Carter A. Increased low-density lipoprotein levels after splenectomy: a role for the spleen in cholesterol metabolism in myeloproliferative disorders. The American Journal of Medicine Science 1986;291:25-8.
  • 9. Taher A, Isma’eel H, Mehio G, et al. Prevalance of thromboembolic events among 8860 patients with thalassamia major and intermedia in the Mediterranean area and Iran. The Journal of Thrombosis and Haemostasis. 2006; 96:488-91.
  • 10. Pamuk GE, Pamuk ON, Başlar Z, etal. Overview of 321 patients with idiopathic thrombocytopenic purpura. Retrospective analysis of the clinical features and response to therapy. Annals of Hematology . 2002;81:436-40.
  • 11. Stasi R, Stipa E, Masi M, et al. Longterm observation of 208 adults with chronic idiopathic thrombocytopenic purpura. The American Journal of Medicine Science. 1995;98:436-42.
  • 12. Durakbasa CU, Timur C, Sehiralti V, et al. Pediatric splenectomy for hematological diseases: outcome analysis. Journal of Pediatric Surgery . 2006;22:635-9.
  • 13. Ozner MD, Ahn YS, Horstmann LL, Jy W, Kolodny L, Myerberg RJ. Chronic platelet activation and acute coronary syndrome in 13 middle-aged patients. Clinical and Applied Thrombosis/He-mostasis. 1997;3:46-53.

İdiopatik Trombositopenik Purpurali Hastada Splenektomiden Sonra Gelişen Akut Koroner Sendrom: Olgu Sunumu

Year 2016, Volume: 8 Issue: 2, 89 - 92, 24.07.2016

Abstract

İdiopatik trombositopenik purpura (ITP), antitrombosit IgG üretimi, kemik iliğinde artmış megakaryosit sayımı ve azalmış trombosit ömrüne bağlı trombosit sayısının azalmasıyla karakterize otoimmün bir hastalıktır. Trombositler akut koroner sen-dromun patogenezinde anahtar rolü bulunmaktadır. Trombositlerin çapı, dansitesi ve aktiviteleri akut koroner sendromu tetikleyebilir. Bu vaka sunumunda, ITP’li hastada splenektomiden 48 saat sonra gelişen akut koroner sendromu sunarak, splenek-tomi sonrası gelişebilecek akut vasküler komplikasyonlara dikkat çekmek istedik.

Dr. Necla DERELİ
Dr. Zehra BAYKAL TUTAL
Dr. Esra ÖZAYAR
Dr. Mehtap KONCA
Dr. Mehmet ŞAHAP
Dr. Eyüp HORASANLI

References

  • 1. Önder A, Kapan M, Gül M, et al. Idiopa-tik trombositopenik purpuralı hastalarda splenektomi: 109 olgunun analizi. Dicle Medical Journal 2012;39:49-53.
  • 2. British Committee for Standarts in Haematology General Haematology Task Force. Guidelines for the investigation and management of idiopathic thrombocytopenic purpura in adults, children and in pregnancy. British Journal of Haematolgy 2003; 120 (4):574-96.
  • 3. Balague C, Targarona EM, Cerdan G, et al. Long-term outcome after lapatasco-pic splenectomy related to hematological diagnosis. Surgical Endoscopy 2004; 18:1283-7.
  • 4. Schwart J, Leber MD, Gillis S, Giunta A, Eldor A, Bussel JB. Long term follow up after splenectomy performed for immune thrombocytopenic purpura (ITP). American Journal Hematolgy 2003; 72:94-8.
  • 5. Vianelli N, Gali M, Vivo A, et al. Efficacy and safety of splenectomy in immune thrombocytopenic purpura: long term results of 402 cases. Haematologica 2005;90:72-7.
  • 6. Crary SE, Buchanan G. Vascular complications after splenectomy for hematologic disorders. Blood 2009;114:2861-8.
  • 7. Visudhiphan S, Ketsa-Ard K, Piankjia-gum A, Tumliang S. Blood coagulation and platelet profiles in persistant postsplenectomy thrombocytosis: the relationship to thromboembolism. Biomed Pharmacother 1985;39:264-71.
  • 8. Aviram M, Brook JG, Tatarsky I, Levy Y, Carter A. Increased low-density lipoprotein levels after splenectomy: a role for the spleen in cholesterol metabolism in myeloproliferative disorders. The American Journal of Medicine Science 1986;291:25-8.
  • 9. Taher A, Isma’eel H, Mehio G, et al. Prevalance of thromboembolic events among 8860 patients with thalassamia major and intermedia in the Mediterranean area and Iran. The Journal of Thrombosis and Haemostasis. 2006; 96:488-91.
  • 10. Pamuk GE, Pamuk ON, Başlar Z, etal. Overview of 321 patients with idiopathic thrombocytopenic purpura. Retrospective analysis of the clinical features and response to therapy. Annals of Hematology . 2002;81:436-40.
  • 11. Stasi R, Stipa E, Masi M, et al. Longterm observation of 208 adults with chronic idiopathic thrombocytopenic purpura. The American Journal of Medicine Science. 1995;98:436-42.
  • 12. Durakbasa CU, Timur C, Sehiralti V, et al. Pediatric splenectomy for hematological diseases: outcome analysis. Journal of Pediatric Surgery . 2006;22:635-9.
  • 13. Ozner MD, Ahn YS, Horstmann LL, Jy W, Kolodny L, Myerberg RJ. Chronic platelet activation and acute coronary syndrome in 13 middle-aged patients. Clinical and Applied Thrombosis/He-mostasis. 1997;3:46-53.
There are 13 citations in total.

Details

Primary Language English
Subjects Anaesthesiology
Journal Section Case Reports
Authors

Zehra Baykal

Publication Date July 24, 2016
Published in Issue Year 2016 Volume: 8 Issue: 2

Cite

APA Baykal, Z. (2016). A Case Of Acute Coronary Syndrome After Splenectomy In An Idiopathic Thrombocytopenic Purpura Patient. Türk Tıp Dergisi, 8(2), 89-92.

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