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A Thyroid Cytology Experience: The Comparision of Cytological and Histopathological Findings

Year 2015, Volume: 22 Issue: 3, 148 - 151, 11.12.2015

Abstract

Aim: Thyroid fine needle aspiration cytology (FNAC) is a common technique used for the follow-up and diagnosis of nodules. FNAC is used for differentiating between benign and malignant lesions preoperatively, and therefore, is helpful to determine the type of surgery. The aim of this study is to screen cases that have been evaluated for thyroid cytology and thyroid surgery specimens in our department, and to investigate the experience of the diagnosis using thyroid fine needle aspiration cytology.

Materials and Methods: In the present study, thyroid fine needle aspiration cytology and surgery specimens obtained from 213 cases that were diagnosed in our pathology department in 2012 were screened retrospectively.

Results: One hundred seventy-seven patients out of 213 were female. Seventy-seven cases were diagnosed with benign cytology on fine needle aspiration cytology. In the histopathological examination of surgical specimens, benign lesions were identified in 63 cases and malignant lesions were identified in 8 cases. According to the histopathological examination of 42 cases that had malignant cytology, 22 cases were diagnosed with papillary carcinoma, and 6 cases were diagnosed with well-differentiated tumor of uncertain malignant potential. When the findings of FNAC and histopathology were compared, the specificity was 75.9%, sensitivity was 73.3%, and the test validity was 75.2%.

Conclusions: The present study supports the notion that fine needle aspiration cytology is a reliable tool for the evaluation of thyroid lesions and the management of patients who are considered for surgery due to complaints of mass lesions.

Key Words: Fine Needle Aspiration Cytology; Histopathology; Thyroid.

References

  • Bagga PK, Mahajan NC: Fine needle aspiration cytology of thyroid swellings: how useful and accurate is it? Indian J Cancer 2010;47(4):437-42.
  • Florentine BD, Staymates B, Rabadi M, Barstis J, Black A: The reliability of fine-needle aspiration biopsy as the initial diagnostic procedure for palpable masses. Cancer 2006;107(2):406-16.
  • Yang J, Schnadig V, Logrono R, Wasserman PG: Fine-needle aspiration of thyroid nodules: a study of 4703 patients with histologic and clinical correlations. Cancer 2007;111(5):306-15.
  • Yerci Ö, Filiz G, Özuysal S, Ertürk E, Gürsoy N, Korun N: Tiroid ince iğne aspirasyon biopsilerinin değerlendirilmesi (1676 olgu). Tr Ekopatoloji Derg 1997;3(1-2):14-8.
  • Cibas ES: Thyroid. In Cibas ED, Ducatman BS, editors. Cytology: Diagnostic Principles and Clinical Correlates, 2nd edition. Philadelphia: Saunders; 2003. p.247-72.
  • Gharib H, Goellner JR: Fine needle aspiration biopsy of the thyroid: an appraisal. Ann Intern Med 1993;118(4): 282-9.
  • Dündar E, Paşaoğlu Ö, Kebapçı M, Bildirici K: Tiroid ince iğne aspirasyon biopsilerinin retrospektif olarak değerlendirilmesi. T Klin Tıp Bilimleri 2002;22:14-7.
  • Afolabi AO, Oluwasola AO, Akute OO, Akang EEU, Ogundiran TO, Ogunbiyi JO et al.: Review of fine needle aspiration cytology in the management of goitres in Ibadan, Nigeria. Niger J Clin Pract 2010;13(2):163-6.
  • Kawai T, Nishihara E, Kudo T, Ota H, Morita S, Kobayashi K et al.:Histopathological diagnoses of ''accessory'' thyroid nodules diagnosed as benign by fine-needle aspiration cytology and ultrasonography. Thyroid 2012;22(3):299-303.
  • Cai XJ, Valiyaparambath N, Nixon P, Waghorn A, Giles T, Helliwell T: Ultrasound- guided fine needle aspiration cytology in the diagnosis and management of thyroid nodules. Cytopathology 2006;17:251-6.
  • Nart D, Ertan Y, Argon A, Sezak M, Veral A, Makay Ö et al.: Tiroid nodüllerinin tanısında ince iğne aspirasyon sitolojisi ve intraoperatif tanı yönteminin rolü. Türk Patoloji Derg 2010;26(1):48-54.
  • Haberal AN, Toru S, Özen Ö, Arat Z, Bilezikçi B: Diagnostic pitfalls in the evaluation of fine needle aspiration cytology of the thyroid: correlation with histopathology in 260 cases. Cytopathology 2009;20:103-8.
  • Çiriş F, Gümüş H, Gümüş M, Yıldırım M, Bakır Z: Nodüler tiroid hastalıklarında ultrasonografi, sintigrafi ve ince iğne aspirasyon biopsisi (İİAB) sonuçlarının karşılştırılması. AÜTD 2002;34:87-91.
  • Jayaram G, Orell SR: Thyroid. In: Orell SR, Sterrett, editors. Orell & Sterrett's fine needle aspiration cytology, 5th edition. Churchill Livingstone;2012. p 118-155.
  • Elliott DD, Pitman MB, Bloom L, Faquin WC: Fine-needle aspiration biopsy of Hurtle cell lesions of the thyroid gland: a cytomorphologic study of 139 cases with statistical analysis. Cancer 2006;108(2):102-9.

Journal of Turgut Ozal Medical Center

Year 2015, Volume: 22 Issue: 3, 148 - 151, 11.12.2015

Abstract

Amaç: Tiroid ince iğne aspirasyon sitolojisi, özellikle tiroid nodülünün ameliyat öncesi değerlendirilmesinde, takibi ve tanısında kullanılan sensitif, spesifik ve düşük maliyeti ile tercih edilen yaygın bir metoddur. İnce iğne aspirasyon sitolojisi ile ameliyat öncesi lezyonun benign ve malign ayrımının yapılması ameliyat şeklinin belirlenmesine yardımcı olmaktadır. Burada, amacımız Patoloji laboratuarımızda sitolojisi ve tiroid ameliyat materyali değerlendirilen olguların taranarak, tiroid ince iğne aspirasyon sitolojisi tanısında tecrübemizi paylaşmak ve literatür bilgileri eşliğinde karşılaştırma yapmaktır. Gereç ve Yöntemler: Bu çalışmada 2012 yılında patoloji laboratuarımızda tanı alan 213 tiroid ince iğne aspirasyon sitolojisi ve ameliyat materyali geriye dönük olarak taranmıştır. Bulgular: İki yüz on üç olgunun 177'si kadındır. Sitolojisi benign olarak tanı alan 77 olgunun ameliyat materyalinin histopatolojik incelemesinde 63'ünde benign, 8'inde malign lezyon tanımlandı. Sitolojisi malign olarak değerlendirilen 42 olgunun histopatolojik incelemesinde ise 22 olgu papiller karsinom, 6 olgu da papiller karsinom şüphesi taşıyan tümoral oluşum olarak tanı aldı. Tiroid ince iğne aspirasyon sitolojisi ve histopatolojik bulgular karşılaştırıldığında spesifitenin %75.9, sensivitenin %73.3, ince iğne aspirasyon sitolojisi testinin geçerliliğinin ise %75.2 olduğu görüldü. Sonuç: Bu çalışma ile tiroid ince iğne aspirasyon sitolojisinin tiroid lezyonlarının değerlendirilmesinde, özellikle operasyon düşünülen ve kitle şikayeti olan hastaların yönetiminde, güvenilir bir araç olduğu tekrar gösterilmiş oldu

References

  • Bagga PK, Mahajan NC: Fine needle aspiration cytology of thyroid swellings: how useful and accurate is it? Indian J Cancer 2010;47(4):437-42.
  • Florentine BD, Staymates B, Rabadi M, Barstis J, Black A: The reliability of fine-needle aspiration biopsy as the initial diagnostic procedure for palpable masses. Cancer 2006;107(2):406-16.
  • Yang J, Schnadig V, Logrono R, Wasserman PG: Fine-needle aspiration of thyroid nodules: a study of 4703 patients with histologic and clinical correlations. Cancer 2007;111(5):306-15.
  • Yerci Ö, Filiz G, Özuysal S, Ertürk E, Gürsoy N, Korun N: Tiroid ince iğne aspirasyon biopsilerinin değerlendirilmesi (1676 olgu). Tr Ekopatoloji Derg 1997;3(1-2):14-8.
  • Cibas ES: Thyroid. In Cibas ED, Ducatman BS, editors. Cytology: Diagnostic Principles and Clinical Correlates, 2nd edition. Philadelphia: Saunders; 2003. p.247-72.
  • Gharib H, Goellner JR: Fine needle aspiration biopsy of the thyroid: an appraisal. Ann Intern Med 1993;118(4): 282-9.
  • Dündar E, Paşaoğlu Ö, Kebapçı M, Bildirici K: Tiroid ince iğne aspirasyon biopsilerinin retrospektif olarak değerlendirilmesi. T Klin Tıp Bilimleri 2002;22:14-7.
  • Afolabi AO, Oluwasola AO, Akute OO, Akang EEU, Ogundiran TO, Ogunbiyi JO et al.: Review of fine needle aspiration cytology in the management of goitres in Ibadan, Nigeria. Niger J Clin Pract 2010;13(2):163-6.
  • Kawai T, Nishihara E, Kudo T, Ota H, Morita S, Kobayashi K et al.:Histopathological diagnoses of ''accessory'' thyroid nodules diagnosed as benign by fine-needle aspiration cytology and ultrasonography. Thyroid 2012;22(3):299-303.
  • Cai XJ, Valiyaparambath N, Nixon P, Waghorn A, Giles T, Helliwell T: Ultrasound- guided fine needle aspiration cytology in the diagnosis and management of thyroid nodules. Cytopathology 2006;17:251-6.
  • Nart D, Ertan Y, Argon A, Sezak M, Veral A, Makay Ö et al.: Tiroid nodüllerinin tanısında ince iğne aspirasyon sitolojisi ve intraoperatif tanı yönteminin rolü. Türk Patoloji Derg 2010;26(1):48-54.
  • Haberal AN, Toru S, Özen Ö, Arat Z, Bilezikçi B: Diagnostic pitfalls in the evaluation of fine needle aspiration cytology of the thyroid: correlation with histopathology in 260 cases. Cytopathology 2009;20:103-8.
  • Çiriş F, Gümüş H, Gümüş M, Yıldırım M, Bakır Z: Nodüler tiroid hastalıklarında ultrasonografi, sintigrafi ve ince iğne aspirasyon biopsisi (İİAB) sonuçlarının karşılştırılması. AÜTD 2002;34:87-91.
  • Jayaram G, Orell SR: Thyroid. In: Orell SR, Sterrett, editors. Orell & Sterrett's fine needle aspiration cytology, 5th edition. Churchill Livingstone;2012. p 118-155.
  • Elliott DD, Pitman MB, Bloom L, Faquin WC: Fine-needle aspiration biopsy of Hurtle cell lesions of the thyroid gland: a cytomorphologic study of 139 cases with statistical analysis. Cancer 2006;108(2):102-9.
There are 15 citations in total.

Details

Primary Language Tr
Journal Section Articles
Authors

Mihriban Gürbüzel This is me

Ayşe Nur Akatlı

Songül Peltek Özer This is me

Şerife Başaran This is me

Kamile Altundal This is me

Saime Gül Barut This is me

Publication Date December 11, 2015
Published in Issue Year 2015 Volume: 22 Issue: 3

Cite

APA Gürbüzel, M., Akatlı, A. N., Peltek Özer, S., Başaran, Ş., et al. (2015). A Thyroid Cytology Experience: The Comparision of Cytological and Histopathological Findings. Journal of Turgut Ozal Medical Center, 22(3), 148-151.
AMA Gürbüzel M, Akatlı AN, Peltek Özer S, Başaran Ş, Altundal K, Barut SG. A Thyroid Cytology Experience: The Comparision of Cytological and Histopathological Findings. J Turgut Ozal Med Cent. December 2015;22(3):148-151.
Chicago Gürbüzel, Mihriban, Ayşe Nur Akatlı, Songül Peltek Özer, Şerife Başaran, Kamile Altundal, and Saime Gül Barut. “A Thyroid Cytology Experience: The Comparision of Cytological and Histopathological Findings”. Journal of Turgut Ozal Medical Center 22, no. 3 (December 2015): 148-51.
EndNote Gürbüzel M, Akatlı AN, Peltek Özer S, Başaran Ş, Altundal K, Barut SG (December 1, 2015) A Thyroid Cytology Experience: The Comparision of Cytological and Histopathological Findings. Journal of Turgut Ozal Medical Center 22 3 148–151.
IEEE M. Gürbüzel, A. N. Akatlı, S. Peltek Özer, Ş. Başaran, K. Altundal, and S. G. Barut, “A Thyroid Cytology Experience: The Comparision of Cytological and Histopathological Findings”, J Turgut Ozal Med Cent, vol. 22, no. 3, pp. 148–151, 2015.
ISNAD Gürbüzel, Mihriban et al. “A Thyroid Cytology Experience: The Comparision of Cytological and Histopathological Findings”. Journal of Turgut Ozal Medical Center 22/3 (December 2015), 148-151.
JAMA Gürbüzel M, Akatlı AN, Peltek Özer S, Başaran Ş, Altundal K, Barut SG. A Thyroid Cytology Experience: The Comparision of Cytological and Histopathological Findings. J Turgut Ozal Med Cent. 2015;22:148–151.
MLA Gürbüzel, Mihriban et al. “A Thyroid Cytology Experience: The Comparision of Cytological and Histopathological Findings”. Journal of Turgut Ozal Medical Center, vol. 22, no. 3, 2015, pp. 148-51.
Vancouver Gürbüzel M, Akatlı AN, Peltek Özer S, Başaran Ş, Altundal K, Barut SG. A Thyroid Cytology Experience: The Comparision of Cytological and Histopathological Findings. J Turgut Ozal Med Cent. 2015;22(3):148-51.