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Glanzmann Thrombasthenia Mimicking Early Neonatal Sepsis

Year 2015, Volume: 22 Issue: 3, 204 - 206, 14.12.2015

Nihat Demir , Sultan Kaba Mesut Garipardiç Erdal Peker Oğuz Tuncer

Abstract

Glanzmann thrombasthenia is an autosomal and recessively inherited disorder resulting from abnormality in the first step of thrombosis. In cases associated with hemorrhagic diathesis and ecchymotic mucocutaneous lesions, Glanzmann thrombasthenia should be taken into account in differential diagnosis if thrombocyte count is normal and bleeding duration is too long. In this study, we present the case of a pair of twins in which one of the siblings was lost in the uterus while the other had sepsis along with common intravascular coagulopathy and was eventually diagnosed with Glanzmann thrombasthenia.

Key Word: Glanzmann; Sepsis; Hemorrhagic Diathesis.

Keywords

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References

  • Glanzmann E. Hereditaire hemorrhagische thrombasthenie. Ein Beitrag zur pathologie der blutplattchen j Kinderkranken 1918;88:113.
  • Neunert CE, Journeycake JM: Congenital platelet disorders. Hematol Oncol Clin North Am 2007; 21:663-84.
  • Israels SJ, Kahr WH, Blanchette VS, Luban NL, Rivard GE, Rand ML: Platelet disorders in children: A diagnostic approach. Pediatr Blood Cancer 2011; 56:975-83.
  • Sebastiano C, Bromberg M, Breen K, Hurford MT. Glanzmann's thrombasthenia: report of a case and review of the literature. Int J Clin Exp Pathol 2010;25;443-7.
  • Kutlubay B, Özdemir GN, Tüysüz G, Apak H, Celkan T. Glanzmann thrombasthenia: Cerrahpaşa Medical Faculty experience. Türk Ped Arfl 2012;47:104-6.
  • Zenciroglu A, Bas AY, Demirel N, Yarali N. Glanzmann thrombasthenia in a neonate. Indian Pediatr 2007;44:40-2.
  • Fışgın T, Koca D. Kalıtsal Trombosit Hastalıkları. Türk Çocuk Hematoloji Dergisi 2011;5:1-10.
  • Karl WM. Intrauterine death in a twin: implications for the survivor. In: Ward RH, Whittle M, editors. Multiple pregnancy. London: RCOG Pres 1995;218-30.
  • Blickstein I, Perlman S. Single fetal death in twin gestations. J Perinat Med 2013;41:65-9.

NihatDemir1, Sultan Kaba2, Mesut Garipardiç2, Erdal Peker1, Oğuz Tuncer1

Year 2015, Volume: 22 Issue: 3, 204 - 206, 14.12.2015

Nihat Demir , Sultan Kaba Mesut Garipardiç Erdal Peker Oğuz Tuncer

Abstract

Glanzmann trombastenisi pıhtı oluşumunun ilk basamağındaki anormalikten kaynaklanan otozomal resesif geçişli kalıtsal bir hastalıktır. Ekimotik mukokütenöz leziyonlarla ve kana diateziyle ilişkili olgularda, eğer trombosit sayısı normal, kanama zamanı uzun ise Glanzamann trombastenisi ayırıcı tanıda düşünülmelidir. Burada ikiz eşi olarak doğan, diğer ikizi intauterin exitus olan ve yaygın intravasküler koagulopati ve sepsis tablosuyla gelen ardından GT tanısı konan bir olgu sunuldu

Keywords

Glanzman Sepsis Kanama Diyatezi

References

  • Glanzmann E. Hereditaire hemorrhagische thrombasthenie. Ein Beitrag zur pathologie der blutplattchen j Kinderkranken 1918;88:113.
  • Neunert CE, Journeycake JM: Congenital platelet disorders. Hematol Oncol Clin North Am 2007; 21:663-84.
  • Israels SJ, Kahr WH, Blanchette VS, Luban NL, Rivard GE, Rand ML: Platelet disorders in children: A diagnostic approach. Pediatr Blood Cancer 2011; 56:975-83.
  • Sebastiano C, Bromberg M, Breen K, Hurford MT. Glanzmann's thrombasthenia: report of a case and review of the literature. Int J Clin Exp Pathol 2010;25;443-7.
  • Kutlubay B, Özdemir GN, Tüysüz G, Apak H, Celkan T. Glanzmann thrombasthenia: Cerrahpaşa Medical Faculty experience. Türk Ped Arfl 2012;47:104-6.
  • Zenciroglu A, Bas AY, Demirel N, Yarali N. Glanzmann thrombasthenia in a neonate. Indian Pediatr 2007;44:40-2.
  • Fışgın T, Koca D. Kalıtsal Trombosit Hastalıkları. Türk Çocuk Hematoloji Dergisi 2011;5:1-10.
  • Karl WM. Intrauterine death in a twin: implications for the survivor. In: Ward RH, Whittle M, editors. Multiple pregnancy. London: RCOG Pres 1995;218-30.
  • Blickstein I, Perlman S. Single fetal death in twin gestations. J Perinat Med 2013;41:65-9.
There are 9 citations in total.

Details

Primary Language Tr
Journal Section Articles
Authors

Nihat Demir

Sultan Kaba This is me

Mesut Garipardiç This is me

Erdal Peker This is me

Oğuz Tuncer This is me

Publication Date December 14, 2015
Published in Issue Year 2015 Volume: 22 Issue: 3

Cite

APA Demir, N., Kaba, S., Garipardiç, M., Peker, E., et al. (2015). Glanzmann Thrombasthenia Mimicking Early Neonatal Sepsis. Journal of Turgut Ozal Medical Center, 22(3), 204-206.
AMA Demir N, Kaba S, Garipardiç M, Peker E, Tuncer O. Glanzmann Thrombasthenia Mimicking Early Neonatal Sepsis. J Turgut Ozal Med Cent. December 2015;22(3):204-206.
Chicago Demir, Nihat, Sultan Kaba, Mesut Garipardiç, Erdal Peker, and Oğuz Tuncer. “Glanzmann Thrombasthenia Mimicking Early Neonatal Sepsis”. Journal of Turgut Ozal Medical Center 22, no. 3 (December 2015): 204-6.
EndNote Demir N, Kaba S, Garipardiç M, Peker E, Tuncer O (December 1, 2015) Glanzmann Thrombasthenia Mimicking Early Neonatal Sepsis. Journal of Turgut Ozal Medical Center 22 3 204–206.
IEEE N. Demir, S. Kaba, M. Garipardiç, E. Peker, and O. Tuncer, “Glanzmann Thrombasthenia Mimicking Early Neonatal Sepsis”, J Turgut Ozal Med Cent, vol. 22, no. 3, pp. 204–206, 2015.
ISNAD Demir, Nihat et al. “Glanzmann Thrombasthenia Mimicking Early Neonatal Sepsis”. Journal of Turgut Ozal Medical Center 22/3 (December 2015), 204-206.
JAMA Demir N, Kaba S, Garipardiç M, Peker E, Tuncer O. Glanzmann Thrombasthenia Mimicking Early Neonatal Sepsis. J Turgut Ozal Med Cent. 2015;22:204–206.
MLA Demir, Nihat et al. “Glanzmann Thrombasthenia Mimicking Early Neonatal Sepsis”. Journal of Turgut Ozal Medical Center, vol. 22, no. 3, 2015, pp. 204-6.
Vancouver Demir N, Kaba S, Garipardiç M, Peker E, Tuncer O. Glanzmann Thrombasthenia Mimicking Early Neonatal Sepsis. J Turgut Ozal Med Cent. 2015;22(3):204-6.
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