CURRENT CANCER STEM CELL BIOMARKERS IN TONGUE SQUAMOUS CELL CARCINOMA

Year 2018, , 197 - 207, 15.10.2018

Omer Faruk Karatas , Seyma Teber Ahmet Yilmaz Asli Baltacioglu Selinay Merve Kilic Emel Poyraz Abdulmelik Aytatli Sumeyye Ozturk Ayse Varol

https://doi.org/10.23902/trkjnat.368829

Abstract

Dil
skuamöz hücreli karsinomu (DSHK) son 5 yılda artan insidans ve mortalite
oranları ile birlikte diğer ağız içi kanserleri arasında en kötü huylu kanser
tipi olarak bilinmektedir. DSHK hastalarının yaşam süreleri sınırlı olduğundan
ve mevcut kemo-radyoterapi yaklaşımlarının başarılı olmamasından dolayı acilen
yeni biyolojik belirteçlere ihtiyaç duyulmaktadır. Diğer solid (katı) tümörlerde
olduğu gibi, DSHK’da da, tümörün başlaması, gelişmesi, yayılması, nüksetmesi ve
kemo-radyoterapiye direnç göstermesi noktasında itici bir güç olarak kabul
edilen “kanser kök hücreleri” (KKH) olarak tanımlanan küçük bir alt popülasyonu
da kapsayan heterojen bir hücre popülasyonuna sahiptir. KKH’nin kanser oluşum
sürecinde nasıl bir katkı yaptıklarının altında yatan moleküler mekanizmalar
tamamen anlaşılamamış olmasına rağmen, bilim insanları ve klinik tedavi
uzmanları DSHK da dâhil olmak üzere kansere karşı mücadelede bu hücreleri
tedavi edici araçlar olarak kullanmayı amaçlamaktadır. Burada, DSHK’daki
potansiyel kanser kök hücrelerinin belirteçlerine ışık tutmak için önemli
bulguları ve en güncel literatürü gözden geçirdik ve derledik. Ayrıca, DSHK
kanser başlangıcı, ilerlemesi, invazyonu ya da metastazı sırasında KKH
biyo-belirteçlerinin olası fonksiyonları özetlenmiştir.

Keywords

Tongue squamous cell carcinoma, cancer stem cell, biomarker

CURRENT CANCER STEM CELL BIOMARKERS IN TONGUE SQUAMOUS CELL CARCINOMA

Abstract

Tongue squamous cell carcinoma (TSCC) is known to be the most malignant
cancer type amongst other oral cancers with increasing incidence and mortality
rates in the past five years. Since the life expectancy for TSCC patients is
limited and the current chemo-radiotherapy treatments are not curative, novel
biomarkers are urgently needed. As many other solid tumors, TSCC has a heterogeneous
cancer cell population, which includes a small subpopulation identified as
cancer stem cells (CSCs) that are considered as the driving force for tumor
initiation, development, spread, recurrence, and resistance to
chemo-radiotherapy. Although the underlying molecular mechanisms of how CSCs
are involved in the carcinogenesis are not completely understood, scientists
and clinicians aim to utilize those cells as therapeutic tools in fight against
different cancer types including TSCC. Here, we reviewed and summarized
important findings and the most current literature to shed light on the
potential of cancer stem cells markers in TSCC. Possible functions of CSCs
biomarkers in TSCC pathogenesis during cancer initiation, progression, invasion
or metastasis are also summarized.

Keywords

cancer stem cell, biomarker, Tongue squamous cell carcinoma

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