EVALUATION OF ANTICANDIDAL EFFECTS OF ESSENTIAL OILS OF COMMERCIAL LAVENDER (Lavandula angustifolia Miller) IN COMBINATION WITH KETOCONAZOLE AGAINTS SOME Candida Berkhout STRAINS

Year 2020, , 13 - 19, 15.04.2020

Gamze Göger , Burcu Akçal Çomoğlu Gökalp İşcan Fatih Demirci

https://doi.org/10.23902/trkjnat.590839

Cited By: 2

Abstract

Application of combination studies with essential oils and
standard antifungal drugs may reduce adverse effects of synthetic drugs and
serve as alternative approach against various pathologies including
candidiasis. The aim of the present study was to determine the interaction
of two commercial lavender (Lavandula angustifolia Miller) essential oils in combination with ketoconazole
against clinical and standard strains of the human pathogens Candida albicans ATCC 10231, C.
krusei NRRL Y-7179 and C. glabrata
ATCC 66032. The chemical compositions of the investigated essential oils were
confirmed both by gas chromatography/flame ionization detector (GC/FID) and gas
chromatography/mass spectrometry (GC/MS) methods. Anticandidal activities of
the essential oils were screened in vitro
by the microdilution method. The resulting interaction of combining lavender
essential oils and ketoconazole was tested using the checkerboard method. The
results showed that the interaction between essential oils and ketoconazole
revealed additive and indifferent effects against the tested strains. In conclusion, the effects
observed by the combination of lavender essential oils and ketoconazole may be
encouraging to be used against pathogenic Candida
strains.

Keywords

Lavender (Lavandula angustifolia), Candida albicans, Candida glabrata, Ketoconazole, Candida krusei

Supporting Institution

Anadolu University Scientific Research

Project Number

Project: 1301S005

Thanks

The authors would like to thank Anadolu University Scientific Research Project: 1301S005 for the financial support.

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