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Melatonin - leptin interaction and obesity-related genes

Year 2025, Issue: Online First

Bülent Gündüz , Emine İnci Balkan

https://doi.org/10.23902/trkjnat.1619680

Abstract

Most living organisms have circadian clocks which maintain rhythm in internal cycles of behavior, physiology, and metabolism, allowing them to anticipate the earth's 24-hour rota-tion. In mammals, circadian integration of metabolic systems optimizes energy gathering and usage across the light and dark cycles. Disruption of circadian rhythms may lead to metabolic dysfunctions such as obesity and obesity-related disorders. The molecular and hormonal mechanism behind obesity is mostly related to mRNA expressions in hypothala-mus, and leptin, and melatonin hormone levels. In obesity and related disorders, the chron-obiotic hormone melatonin regulates physiological functions such as energy metabolism, body fat, and reproduction by cross-interacting with leptin. Leptin signals satiety by inhibit-ing Neuropeptide Y/Agouti-Related Peptide (NPY/AgRP genes in hypothalamus and exerts its effects on food intake, body weight, and the reproductive system. In this review, the mo-lecular and hormonal mechanisms behind obesity were discussed.

Keywords

Agouti-Related Protein (AgRP) Endocrine Gene Expression Neuropeptide Y (NPY) Suprachiasmatic Nuclei (SCN)

Ethical Statement

Since the article does not contain any studies with human or animal subject, its approval to the ethics committee was not required.

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Year 2025, Issue: Online First

Bülent Gündüz , Emine İnci Balkan

https://doi.org/10.23902/trkjnat.1619680

Abstract

Çoğu canlı organizmanın, davranış, fizyoloji ve metabolizmanın iç döngülerinde ritmi koru-yan sirkadiyen saatleri vardır ve bu da organizmaların dünyanın 24 saatlik dönüşünü tahmin etmelerine olanak tanır. Memelilerde, metabolik sistemlerin sirkadiyen entegrasyonu, ışık ve karanlık döngüleri boyunca enerji toplanmasını ve kullanımını optimize eder. Sirkadiyen ritimlerin bozulması obezite ve obeziteye bağlı bozukluklar gibi metabolik işlev bozuklukla-rına yol açabilir. Obezitenin arkasındaki moleküler ve hormonal mekanizma çoğunlukla hi-potalamustaki mRNA ifadeleri ve leptin ve melatonin hormonlarının seviyeleriyle ilişkilidir. Obezite ve ilgili bozukluklarda kronobiyotik bir hormon olan melatonin, leptin ile çapraz etkileşime girerek enerji metabolizması, vücut yağı ve üreme gibi fizyolojik işlevleri düzen-ler. Leptin hormonu hipotalamustaki Nöropeptid Y/Agouti İlgili Peptid (NPY/AgRP) genle-rini inhibe ederek tokluk sinyali verir ve besin alımı, vücut ağırlığı ve üreme sistemi üzerin-de etkilerini gösterir. Bu derlemede obezitenin arkasındaki moleküler ve hormonal meka-nizmalar tartışılmıştır.

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There are 67 citations in total.

Details

Primary Language English
Subjects Animal Developmental and Reproductive Biology, Animal Neurobiology
Journal Section Review/Derleme
Authors

Bülent Gündüz 0000-0003-0497-8287

Emine İnci Balkan 0000-0002-2708-2427

Early Pub Date March 21, 2025
Publication Date
Submission Date January 14, 2025
Acceptance Date March 13, 2025
Published in Issue Year 2025 Issue: Online First

Cite

APA Gündüz, B., & Balkan, E. İ. (2025). Melatonin - leptin interaction and obesity-related genes. Trakya University Journal of Natural Sciences(Online First). https://doi.org/10.23902/trkjnat.1619680
AMA Gündüz B, Balkan Eİ. Melatonin - leptin interaction and obesity-related genes. Trakya Univ J Nat Sci. March 2025;(Online First). doi:10.23902/trkjnat.1619680
Chicago Gündüz, Bülent, and Emine İnci Balkan. “Melatonin - Leptin Interaction and Obesity-Related Genes”. Trakya University Journal of Natural Sciences, no. Online First (March 2025). https://doi.org/10.23902/trkjnat.1619680.
EndNote Gündüz B, Balkan Eİ (March 1, 2025) Melatonin - leptin interaction and obesity-related genes. Trakya University Journal of Natural Sciences Online First
IEEE B. Gündüz and E. İ. Balkan, “Melatonin - leptin interaction and obesity-related genes”, Trakya Univ J Nat Sci, no. Online First, March 2025, doi: 10.23902/trkjnat.1619680.
ISNAD Gündüz, Bülent - Balkan, Emine İnci. “Melatonin - Leptin Interaction and Obesity-Related Genes”. Trakya University Journal of Natural Sciences Online First (March 2025). https://doi.org/10.23902/trkjnat.1619680.
JAMA Gündüz B, Balkan Eİ. Melatonin - leptin interaction and obesity-related genes. Trakya Univ J Nat Sci. 2025. doi:10.23902/trkjnat.1619680.
MLA Gündüz, Bülent and Emine İnci Balkan. “Melatonin - Leptin Interaction and Obesity-Related Genes”. Trakya University Journal of Natural Sciences, no. Online First, 2025, doi:10.23902/trkjnat.1619680.
Vancouver Gündüz B, Balkan Eİ. Melatonin - leptin interaction and obesity-related genes. Trakya Univ J Nat Sci. 2025(Online First).

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