A Study on Effect of Melatonin in Dyslipidemia Caused by Experimentally Diabetes

Year 2019, Volume: 21 Issue: 1, 117 - 121, 30.04.2019

Deniz Uluışık , Ercan Keskin , Durmuş Hatipoğlu

https://doi.org/10.15314/tsed.541834

Abstract

In this study, it was
aimed to determine the effects of melatonin application on lipid profile in streptozotocin-induced diabetic rats. Animals in control group were not any
treatment. Melatonin group animals received 50 mg/kg melatonin
intraperitoneally in daily for eight weeks. Diabetes was induced by
subcutaneous injections of streptozotocin at dose of 40 mg/kg for two days as a
single dose per day in diabetes group animals. Animals in Diabetes+Melatonin
group were made diabetic by streptozotocin
in the same way and then these animals received 50 mg/kg melatonin
intraperitoneally in daily for eight weeks. In blood samples taken from all animals, TNF-α,
triglyceride, total cholesterol, LDL and HDL were determined. In diabetes
group, TNF-α level were high (p<0.05). The changes in TNF-α level with
melatonin application to diabetic rats were important (p<0.05). In diabetic
rats, triglyceride and LDL levels were found to be enhanced compared to control
group (p<0.05), HDL level was significantly low (p<0.05), while the
change in total cholesterol level was not important. With the melatonin
application to diabetic rats, HDL level was found to be higher (p<0.05) and
LDL level was lower than diabetes group (p<0.05). It was concluded that the
administration of melatonin to streptozotocin-induced diabetic rats may have positive effects on lipid profile.

Keywords

Diabetes, melatonin, TNF-α, lipid profile

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