FİTOTERAPİDE BİTKİSEL DROGLARLA GİS (GASTROİNTESTİNAL SİSTEM) HASTALIKLARININ TEDAVİSİ

Year 2023, Volume: 16 Issue: 1, 1 - 15, 23.03.2023

Büşra Gündüz Çoban

Abstract

Fitoterapi, bitkileri ya hastalıkları tedavi etmek için ya da sağlığı geliştirici ajanlar olarak kullanan bir tıp alanıdır. Fitoterapi günümüzde birçok hastalıkta kullanılabilmektedir. Bunlardan birisi de gastrointestinal sistem hastalıklarıdır. Bu doğrultuda bu çalışmada fitoterapide bitkisel droglarla GİS (gastrointestinal sistem) hastalıklarının tedavisinin ele alınması amaçlanmıştır. Bu doğrultuda barsak enflamasyonunda, şişkinlik/gazda, kabızlıkta ve ishalde kullanılan bitkisel droglar, bitkisel çaylar, bitkisel aroma ve uçucu yağlar literatür ışığında ele alınmıştır. Yapılan çalışma sonucunda çeşitli bitkisel drogların GİS (gastrointestinal sistem) hastalıklarının tedavisinde etkin şekilde kullanıldığı sonucuna varılmıştır. Ancak günümüzde halen bitkisel ilaçların kullanımı, diğer adıyla fitoterapi, sağlık çalışanları tarafından çoğunlukla bilgi eksikliğinden dolayı pek kabul görmemektedir. Bitkisel ilaçların birçok potansiyeli bulunduğu gibi yanlış kullanım sonucunda önemli zararlı etkileri de olabilmektedir. Bu bağlamda bu sürecin sağlık profesyonelleri eşliğinde yürütülmesi oldukça önemlidir.

Keywords

Fitoterapi, Bitkisel Drog, Gastrointestinal Sistem Hastalıkları

References

• Ahmad, S., & Mika, D. (2012). Chemoprotective and immunomodulatory effect of Acacia nilotica during cyclophosphamide induced toxicity. Journal of experimental therapeutics & oncology, 10(2).
• Akah, P. A., Aguwa, C. N., & Agu, R. U. (1999). Studies on the antidiarrhoeal properties of Pentaclethra macrophylla leaf extracts. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 13(4), 292-295.
• Akram, M., Daniyal, M., Ali, A., Khan, I. A., Zainab, R., Usmanghani, K., & Wang, W. (2020). Current Knowledge and Therapeutic Strategies of Herbal Medicine for Acute Diarrhea. Perspective of Recent Advances in Acute Diarrhea.
• Ali, M., & Chaudhary, N. (2011). Ficus hispida Linn.: A review of its pharmacognostic and ethnomedicinal properties. Pharmacognosy reviews, 5(9), 96.
• Ananthakrishnan, A. N. (2015). Epidemiology and risk factors for IBD. Nature reviews Gastroenterology & hepatology, 12(4), 205.
• Andres, P. G., & Friedman, L. S. (1999). Epidemiology and the natural course of inflammatory bowel disease. Gastroenterology Clinics of North America, 28(2), 255-281.
• Aranda-Michel, J., & Giannella, R. A. (1999). Acute diarrhea: a practical review. The American journal of medicine, 106(6), 670-676.
• Asif, A., Kakub, G., Mehmood, S., Khunum, R., & Gulfraz, M. (2007). Wound healing activity of root extracts of Berberis lyceum Royle in rats. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 21(6), 589-591.
• Bahrami, H. R., Hamedi, S., Salari, R., & Noras, M. (2016). Herbal medicines for the management of irritable bowel syndrome: a systematic review. Electronic physician, 8(8), 2719.
• Baumgart, D. C., & Sandborn, W. J. (2012). Crohn's disease. The Lancet, 380(9853), 1590-1605.
• Bello, I., Usman, N. S., Mahmud, R., & Asmawi, M. Z. (2015). Mechanisms underlying the antihypertensive effect of Alstonia scholaris. Journal of ethnopharmacology, 175, 422-431.
• Ben-Arye, E., Goldin, E., Wengrower, D., Stamper, A., Kohn, R., & Berry, E. (2002). Wheat grass juice in the treatment of active distal ulcerative colitis: a randomized double-blind placebo-controlled trial. Scandinavian journal of gastroenterology, 37(4), 444-449.
• Bukovská, A., Cikoš, Š., Juhás, Š., Il’ková, G., Rehák, P., & Koppel, J. (2007). Effects of a combination of thyme and oregano essential oils on TNBS-induced colitis in mice. Mediators of inflammation, 2007.
• Capasso, F., & Gaginella, T. S. (2012). Laxatives: a practical guide. Springer Science & Business Media.
• Capasso, F., Borrelli, F., Capasso, R., Carlo, G. D., Izzo, A. A., Pinto, L., ... & Longo, R. (1998). Aloe and its therapeutic use. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 12(S1), S124-S127.
• Capasso, F., Gaginella, T. S., Grandolini, G., & Izzo, A. A. (2003). Phytotherapy: a quick reference to herbal medicine. Springer Science & Business Media.
• Capasso, R., Laudato, M., & Borrelli, F. (2013). Meeting Report: First National Meeting on Aloe, April 20–21, 2013, Isernia, Italy New Perspectives in Aloe Research: From Basic Science to Clinical Application. Natural Product Communications, 8(9), 1934578X1300800937.
• Chen, Z. S., Nie, Z. W., & Sun, Q. L. (1994). Clinical study in treating intractable ulcerative colitis with traditional Chinese medicine. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi Jiehe Zazhi= Chinese Journal of Integrated Traditional and Western Medicine, 14(7), 400-402.
• Cirillo, C., & Capasso, R. (2015). Constipation and botanical medicines: an overview. Phytotherapy Research, 29(10), 1488-1493.
• Colalto, C. (2018). What phytotherapy needs: Evidence‐based guidelines for better clinical practice. Phytotherapy research, 32(3), 413-425.
• Danese, S., Fiorino, G., Peyrin-Biroulet, L., Lucenteforte, E., Virgili, G., Moja, L., & Bonovas, S. (2014). Biological agents for moderately to severely active ulcerative colitis: a systematic review and network meta-analysis. Annals of internal medicine, 160(10), 704-711.
• Daryani, N. E., Keramati, M. R., Habibollahi, P., Pashaei, M. R., Ansarinejad, N., & Ajdarkosh, H. (2009). Colonic diverticular abscess presenting as chronic diarrhea: a case report. Cases Journal, 2(1), 1-5.
• Das, A. K., Mandal, S. C., Banerjee, S. K., Sinha, S., Das, J., Saha, B. P., & Pal, M. (1999). Studies on antidiarrhoeal activity of Punica granatum seed extract in rats. Journal of ethnopharmacology, 68(1-3), 205-208.
• Davies, M., & Mayne, A. (2001). Oral rehydration therapy. Archives of Disease in Childhood, 84(3), 199.
• Drossman, D. A. (2006). The functional gastrointestinal disorders and the Rome III process. gastroenterology, 130(5), 1377-1390.
• Dryden, G. W., Lam, A., Beatty, K., Qazzaz, H. H., & McClain, C. J. (2013). A pilot study to evaluate the safety and efficacy of an oral dose of (−)-epigallocatechin-3-gallate–rich Polyphenon E in patients with mild to moderate ulcerative colitis. Inflammatory bowel diseases, 19(9), 1904-1912.
• Fabian, D., Juhás, Š., Bukovská, A., Bujňáková, D., Grešáková, Ľ., & Koppel, J. (2011). Anti-inflammatory effects of chamomile essential oil in mice. Slovak Journal of Animal Science, 44(3), 111-116.
• Falzon, C. C., & Balabanova, A. (2017). Phytotherapy: An introduction to herbal medicine. Primary Care: Clinics in Office Practice, 44(2), 217-227.
• Foxworthy, D. M., & Wilson, J. A. (1985). Crohn's disease in the elderly: Prolonged delay in diagnosis. Journal of American Geriatrics Society, 33, 492-495.
• Fürst, R., & Zündorf, I. (2015). Evidence‐based Phytotherapy in Europe: Where do we stand? Planta Medica, 81, 962–967.
• Ghule, B. V., Murugananthan, G., Nakhat, P. D., & Yeole, P. G. (2006). Immunostimulant effects of Capparis zeylanica Linn. leaves. Journal of ethnopharmacology, 108(2), 311-315.
• Gilani, A. H., Khan, A. U., Ali, T., & Ajmal, S. (2008). Mechanisms underlying the antispasmodic and bronchodilatory properties of Terminalia bellerica fruit. Journal of Ethnopharmacology, 116(3), 528-538.
• Gupta, I., Parihar, A., Malhotra, P., Gupta, S., Lüdtke, R., Safayhi, H., & Ammon, H. P. (2001). Effects of gum resin of Boswellia serrata in patients with chronic colitis. Planta medica, 67(05), 391-395.
• Huber, R., Ditfurth, A. V., Amann, F., Güthlin, C., Rostock, M., Trittler, R., ... & Merfort, I. (2007). Tormentil for active ulcerative colitis: an open-label, dose-escalating study. Journal of clinical gastroenterology, 41(9), 834-838.
• Kelber, O., Bauer, R., & Kubelka, W. (2017). Phytotherapy in functional gastrointestinal disorders. Digestive Diseases, 35(S1), 36-42.
• Kim, D. H., & Cheon, J. H. (2017). Pathogenesis of inflammatory bowel disease and recent advances in biologic therapies. Immune network, 17(1), 25-40.
• Larijani, B., Esfahani, M. M., Moghimi, M., Ardakani, M. R. S., Keshavarz, M., Kordafshari, G., ... & Zargaran, A. (2016). Prevention and treatment of flatulence from a traditional Persian medicine perspective. Iranian Red Crescent Medical Journal, 18(4).
• Levine, A. C., Shah, S. P., Umulisa, I., Mark Munyaneza, R. B., Dushimiyimana, J. M., Stegmann, K., ... & Noble, V. E. (2010). Ultrasound assessment of severe dehydration in children with diarrhea and vomiting. Academic Emergency Medicine, 17(10), 1035-1041.
• Mandal, S. C., & Kumar, C. A. (2002). Studies on anti-diarrhoeal activity of Ficus hispida. Leaf extract in rats. Fitoterapia, 73(7-8), 663-667.
• Misar, A., Bhagat, R., & Mujumdar, A. M. (2007). Antidiarrhoeal activity of Acacia nilotica Willd. bark methanol extract. Hindustan antibiotics bulletin, 49(1-4), 14-20.
• Molodecky, N. A., Soon, S., Rabi, D. M., Ghali, W. A., Ferris, M., Chernoff, G., Kaplan, G. G. (2012). Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology, 142(1), 46-54.
• Mulla, W. A., Chopade, A. R., Bhise, S. B., Burade, K. B., & Khanwelkar, C. C. (2011). Evaluation of antidiarrheal and in vitro antiprotozoal activities of extracts of leaves of Alocasia indica. Pharmaceutical biology, 49(4), 354-361.
• Nampoothiri, S. V., Prathapan, A., Cherian, O. L., Raghu, K. G., Venugopalan, V. V., & Sundaresan, A. (2011). In vitro antioxidant and inhibitory potential of Terminalia bellerica and Emblica officinalis fruits against LDL oxidation and key enzymes linked to type 2 diabetes. Food and Chemical Toxicology, 49(1), 125-131.
• Nasiri, A. A., Pakmehr, M., Shahdadi, H., Balouchi, A., Sepehri, Z., & Ghalenov, A. R. (2016). A comparative study of dimethicone and supermint anti-flatulence effects on reducing flatulence in patients with irritable bowel syndrome. Der Pharmacia Lettre, 8(1), 97-101.
• Nataro, J. P., & Kaper, J. B. (1998). Diarrheagenic Escherichia coli. Clinical Microbiology Reviews, 11(1), 142-201.
• Nikkhah-Bodaghi, M., Maleki, I., Agah, S., & Hekmatdoost, A. (2019). Zingiber officinale and oxidative stress in patients with ulcerative colitis: A randomized, placebo-controlled, clinical trial. Complementary therapies in medicine, 43, 1-6.
• Niu, J., Miao, J., Tang, Y., Nan, Q., Liu, Y., Yang, G., ... & Miao, Y. (2016). Identification of environmental factors associated with inflammatory bowel disease in a southwestern highland region of China: a nested case-control study. PLoS One, 11(4), e0153524.
• Patwardhan, B., Bhutani, K. K., Patki, P. S., Dange, S. V., Gore, D. V., Borole, D. I., ... & Paranjpe, P. V. (1990). Clinical evaluation of Terminalia belerica in diarrhoea. Ancient Science of Life, 10(2), 94.
• Priya, K. S., Arumugam, G., Rathinam, B., Wells, A., & Babu, M. (2004). Celosia argentea Linn. leaf extract improves wound healing in a rat burn wound model. Wound Repair and Regeneration, 12(6), 618-625.
• Rahman, M. T., Khan, O. F., Saha, S., & Alimuzzaman, M. (2003). Antidiarrhoeal activity of the bark extract of Careya arborea Roxb. Fitoterapia, 74(1-2), 116-118.
• Rashidian, A., Roohi, P., Mehrzadi, S., Ghannadi, A. R., & Minaiyan, M. (2016). Protective effect of Ocimum basilicum essential oil against acetic acid–induced colitis in rats. Journal of evidence-based complementary & alternative medicine, 21(4), NP36-NP42.
• Rokaya, M. B., Uprety, Y., Poudel, R. C., Timsina, B., Münzbergová, Z., Asselin, H., ... & Sigdel, S. R. (2014). Traditional uses of medicinal plants in gastrointestinal disorders in Nepal. Journal of ethnopharmacology, 158, 221-229.
• Sandborn, W. J., Targan, S. R., Byers, V. S., Rutty, D. A., Mu, H., Zhang, X., & Tang, T. (2013). Andrographis paniculata extract (HMPL-004) for active ulcerative colitis. The American journal of gastroenterology, 108(1), 90.
• Sassi, K. (2018). https://www.everydayhealth.com/excessive-gas/home-remedies-for-gas/
• Shah, A. J., Bhulani, N. N., Khan, S. H., ur Rehman, N., & Gilani, A. H. (2010). Calcium channel blocking activity of Mentha longifolia L. explains its medicinal use in diarrhoea and gut spasm. Phytotherapy Research, 24(9), 1392-1397.
• Shapira, S., Leshno, A., Katz, D., Maharshak, N., Hevroni, G., Jean-David, M., ... & Arber, N. (2018). Of mice and men: A novel dietary supplement for the treatment of ulcerative colitis. Therapeutic Advances in Gastroenterology, 11, 1756283X17741864.
• Sharma, P., Gali Vidyasagar, S. S., Ghule, S., & Kumar, B. (2010). Antidiarrhoeal activity of leaf extract of Celosia Argentea in experimentally induced diarrhoea in rats. Journal of advanced pharmaceutical technology & research, 1(1), 41.
• Shedayi, A. A., & Gulshan, B. (2012). Ethnomedicinal uses of plant resources in Gilgit-Baltistan of Pakistan. Journal of Medicinal Plants Research, 6(29), 4540-4549.
• Sini, K. R., Sinha, B. N., & Rajasekaran, A. (2011). Antidiarrheal activity of Capparis zeylanica leaf extracts. Journal of Advanced Pharmaceutical Technology & Research, 2(1), 39.
• Spisni, E., Petrocelli, G., Imbesi, V., Spigarelli, R., Azzinnari, D., Donati Sarti, M., ... & Valerii, M. C. (2020). Antioxidant, anti-inflammatory, and microbial-modulating activities of essential oils: Implications in colonic pathophysiology. International Journal of Molecular Sciences, 21(11), 4152.
• Srivastava, J. K., Shankar, E., & Gupta, S. (2010). Chamomile: A herbal medicine of the past with a bright future. Molecular medicine reports, 3(6), 895-901.
• Tack, J., Müller‐Lissner, S., Stanghellini, V., Boeckxstaens, G., Kamm, M. A., Simren, M., ... & Fried, M. (2011). Diagnosis and treatment of chronic constipation–a European perspective. Neurogastroenterology & Motility, 23(8), 697-710.
• Taleban, S. (2015). Challenges in the diagnosis and management of inflammatory bowel disease in the elderly. Current treatment options in gastroenterology, 13(3), 275-286.
• Triantafyllidi, A., Xanthos, T., Papalois, A., & Triantafillidis, J. K. (2015). Herbal and plant therapy in patients with inflammatory bowel disease. Annals of gastroenterology: quarterly publication of the Hellenic Society of Gastroenterology, 28(2), 210.
• Wang, X., & Yin, J. (2015). Complementary and alternative therapies for chronic constipation. Evidence-Based Complementary and Alternative Medicine, 2015.
• Winney, J. (1998. Constipation). Nurs Stand, 13, 49–53.
• Zhang, F., Li, Y., Xu, F., Chu, Y., & Zhao, W. (2013). Comparison of Xilei-san, a Chinese herbal medicine, and dexamethasone in mild/moderate ulcerative proctitis: a double-blind randomized clinical trial. The journal of alternative and complementary medicine, 19(10), 838-842.