Yeni nesil kanser terapisinde hedefleme stratejileri ve ligandları

Year 2024, Volume: 5 Issue: 1, 39 - 52, 22.05.2024

Mustafa Cengiz , Canan Vejselova Sezer

Abstract

Kanser günümüzde dünya çapında mortalitesi yüksek bir hastalıktır. Geleneksek kanser tedavi ajanları ve modern immünoterapilerde karşılaşılan yan etkileri ve tümör hedefli olmayan stratejileri kapsamakta olup yeni tedavi yaklaşımları ve ajanlarının keşfi ve kullanımını gerektirmektedir. Nanobilim ve nanoteknoloji son yıllarda sağlık alanında yeni uygulama ve ajanların geliştirilmesi, tanımlanması ve kullanımına olanak sağlamıştır. Nanoteknolojik ürün olarak ortaya konulan terapi ajanları kapsüllenmiş antikanser ajanlarının hedef dışı toksisitesini azaltma, terapötik etkinliği artırma ve tedavi ajanını hücreye ya da organele özgü hedeflemeyi amaçlayan nanotaşıyıcıların geliştirilmesi ve kullanımına yol açmıştır. Bu derlemede, tümör hücresi hedefli antikanser nanoilaçlarının tasarlanmasında mevcut stratejiler ve bununla ilgili gelecek stratejiler ele alınmıştır.

Keywords

Kanser, nanoteknoloji, tümör hücresi, antikanser

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