Obezite Yönetiminde Adipoz Doku Kahverengileşmesi

Year 2023, , 81 - 91, 28.04.2023

Hümeyra Başkent , Nazlı Nur Aslan Çin , Taner Bayraktaroğlu , Figen Barut

https://doi.org/10.25048/tudod.1250627

Cited By: 1

Abstract

Tüm dünya sorunu olan obezitenin tedavisinde güncel olarak terapötik stratejiler geliştirilmektedir. Memelilerde, işlevleri ve morfolojileri
bakımından farklılık gösteren farklı iki tip adipoz doku mevcuttur. Bunlar, embriyogenez sırasında ortaya çıkan kahverengi adipoz
doku (KAD); ve doğum sonrası gelişen beyaz adipoz dokudur (BAD). KAD’nun hacmi, enerji harcaması ile pozitif ilişkili olduğu ve
obez kişilerde zayıf bireylere göre önemli ölçüde düşük olduğu bilinmektedir. KAD indüksiyonunu ve/veya aktivasyonunu hedefleyen
stratejiler, obezite tedavisinde potansiyel olarak faydalı olabileceği düşünülmektedir. Son yıllarda yapılan araştırmalar, KAD aktivasyonu
ve BAD kahverengileşmesi ile ilgili mekanizmalar üzerine olan ilgiyi önemli ölçüde artırmaktadır. Bu mekanizmaları amaçlayan kimyasal
bileşiklerin yanı sıra çeşitli farmakolojik olmayan bazı müdahale yaklaşımları bulunmaktadır. Bu derlemede, KAD aktivasyonu ve BAD
kahverengileşmesi sürecindeki potansiyel terapötik hedefler ve bunları amaçlayan mevcut stratejilere ilişkin kavramlar özetlenmiştir

Keywords

Kahverengi adipoz doku, beyaz adipoz doku, adipoz doku kahverengileşmesi, termogenez, obezite

Adipose Tissue Browning in Obesity Management

Abstract

Recently, therapeutic strategies have been developed for the treatment of obesity, which is a worldwide problem. There are two different
types of adipose tissue in mammals that differ in their function and morphology. These are brown adipose tissue (BAT), which develops
during embryogenesis and white adipose tissue (WAT), which develops after postnatal. It is known that the volume of BAT is positively
associated with energy discharge and is significantly lower in obese individuals than in slim individuals. Strategies targeting the BAT
induction and/or activation are considered potentially useful in the treatment of obesity. Recent research initiatives have significantly
attracted the interest in the mechanisms associated with the BAT activation and WAT browning. In addition to the chemical compounds
focusing on these mechanisms, there are various non-pharmacological intervention approaches. In this review, potential therapeutic
targets in BAT activation and WAT browning process as well as the concepts related to the strategies targeting them are summarized

Keywords

Brown adipose tissue, white adipose tissue, adipose tissue browning, thermogenesis, obesity

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