Evaluation of the Relationship between Obesity and Obesity Type and Endometrial Thickness-Endometrial Pathologies

Year 2020, , 253 - 259, 29.12.2020

Anıl Turhan Çakır , Sadun Sucu

https://doi.org/10.25048/tudod.771481

Abstract

Aim: Obesity is associated with many problems, including gynecological diseases. It can cause anovulation, abnormal uterine bleeding,
endometrial polyp, endometrial hyperplasia and cancer by affecting various metabolic pathways and disrupting hormonal balance.
The main source of estrogen in the postmenopausal period is the peripheral aromatization of androgens in adipose tissue. Increasing
estrogen level with increased adipose tissue with obesity may affect the endometrial thickness measured by ultrasonography. In the
evaluation of obesity, measurements such as Body Mass Index (BMI), waist / hip ratio, waist circumference, waist / height ratio, neck circumference can be used. The aim of this study was to investigate the relationship between BMI and waist / hip ratio with endometrial
pathologies and endometrial thickness measured by ultrasonography in postmenopausal patients.
Material and Methods: Patients who were admitted to the gynecology outpatient clinic of Zonguldak Maternity and Children Hospital
between February 2020 and April 2020 due to abnormal uterine bleeding and planned for endometrial biopsy were included in the
study. Patient’s height, weight, waist and hip measurements were taken. BMI and waist / hip ratios of the patients were calculated from
the measurements obtained. Endometrial biopsy pathology results and endometrial thicknesses measured by ultrasonography during
the routine examination of patients in the postmenopausal period were recorded.
Results: There was no statistical difference between endometrial sampling results and waist / hip ratio (p = 0.091), BMI averages (p =
0.094) and BMI groups (p = 0.194, p = 0.121). No statistical difference was found between the endometrial thicknesses measured by
ultrasonography in the postmenopausal period and BMI groups and waist / hip ratio (p = 0.879 and p = 0.935).
Conclusion: In our study, no relation was found between BMI groups and waist / hip ratios, endometrial pathologies and endometrial
thickness measurements in the postmenopausal period. Different results can be obtained by using different methods in the evaluation
of obesity, adding biochemical parameters and increasing the number of patients.

Keywords

Obesity,, Body mass index, Uterine bleeding, Endometrial diseases

Obezite ve Tipinin Endometrial Kalınlık ve Endometrial Patolojiler ile İlişkisinin Değerlendirilmesi

Abstract

Amaç: Obezite jinekolojik hastalıklar da dâhil olmak üzere birçok sorun ile ilişkilidir. Çeşitli metabolik yolakları etkileyerek ve
hormonal dengeyi bozarak anovulasyon, anormal uterin kanama, endometrial polip, endometrial hiperplazi ve kansere sebep olabilir.
Postmenopozal dönemde ana östrojen kaynağı, yağ dokusunda androjenlerin periferik aromatizasyonudur. Obezite ile artmış yağ
dokusu ile birlikte artan östrojen düzeyi ultrasonografi ile ölçülen endometrial kalınlığa etki edebilir. Obezitenin değerlendirilmesinde
Beden Kitle İndeksi (BKİ), bel/kalça oranı, bel çevresi, bel/boy oranı, boyun çevresi gibi ölçümler kullanılabilir. Çalışmada BKİ ve
bel/kalça oranının endometrial patolojiler ve postmenopozal dönemdeki hastalarda ultrasonografi ile ölçülen endometrial kalınlık ile
ilişkisi incelenmesi amaçlandı.
Gereç ve Yöntemler: Şubat 2020-Nisan 2020 tarihleri arasında Zonguldak Kadın-Doğum ve Çocuk Hastalıkları Hastanesi jinekoloji
polikliniğine anormal uterin kanama nedeni ile başvuran ve endometrial biyopsi planlanan hastaların boy, kilo, bel ve kalça ölçüleri alındı.
Hastaların BKİ’leri ve bel/kalça oranları elde edilen ölçümlerden hesaplandı. Endometrial biyopsi patoloji tanıları ve postmenopozal
dönemdeki hastaların rutin muayene sırasında ultrasonografi ile ölçülen endometrial kalınlıkları kayıt altına alındı.
Bulgular: Hastaların endometrial patoloji tanıları ile bel/kalça oranı (p=0,091), BKİ değerleri (p=0,094) ve BKİ grupları (p=0,194,
p=0,121) arasında fark saptanmadı. Postmenopozal dönemdeki hastaların ultrasonografide ölçülen endometrial kalınlıkları arasında
BKİ grupları ve bel/kalça oranı açısından fark saptanmadı (sırasıyla p=0,879 ve p=0,935).
Sonuç: Çalışmamızda BKİ grupları ve bel/kalça oranları açısından endometrial patolojiler ve postmenopozal dönemdeki endometrial
kalınlık ölçümleri arasında fark bulunamamıştır. Obezitenin değerlendirilmesinde farklı yöntemlerin de kullanılması, biyokimyasal
parametrelerin eklenmesi ve hasta sayısının artırılması ile farklı sonuçlar elde edilebilir.

Keywords

Obezite, beden kitle indeksi, uterus kanaması, endometriyal hastalıklar

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