Research Article
18-FDG PET/CT ile Belirlenen Kahverengi Yağ Dokusu Glukoz Uptake’i ile Açlık Kan Glukozunun İlişkisi
Abstract
Amaç: Enerji metabolizması ve kahverengi yağ dokusu arasındaki ilişki birçok çalışmada gösterildiğinden, supraklaviküler kahverengi yağdokusunun glukoz uptake’ini, prediyabetli bireylerde 18F-FDG PET / CT görüntüleme yöntemi kullanılarak etkilenip etkilenmediğini araştırmayı amaçladık.
Gereç ve Yöntemler: Gazi Yaşargil Eğitim ve Eğitim Hastanesi Nükleer Tıp Kliniğine Şubat-Mayıs ayları arasında başvuran kanser hastalarının retrospektif bir derlemesini yaptık. Yüz otuz bir hasta açlık kan glukoz düzeylerine göre iki gruba ayrıldı: normoglisemik grup (kan glukoz düzeyi ≤99 mg / dl, n=71) ve prediyabetik grup (kan glukoz düzeyi≥100mg/dl, n=60). Tüm hastaların vücut kütle indeksi hesaplandı. Ortalama SUVmax ve SUVmean kahverengi adipoz dokusu ve deri altı adipoz dokusu verileri, 18-FDG PET / CT ile ölçüldü. Bu çalışma Dicle Üniversitesi etik kurulu (119-2019) tarafından onaylandı. İstatistiksel analiz için iki ortalama arasındaki farkın önemlilik testi ve ki-kare testi kullanıldı.
Bulgular: Normoglisemik grup ile prediyabetik grup arasında ağırlık, boy ve VKİ açısından fark yoktu. Her iki grupta cinsiyet dağılımında fark yoktu. Supraklaviküler bölgeden normoglisemik grubun kahverengi yağ dokusu SUVmax ve SUVmean değerleri prediyabetik gruba göre anlamlı derecede yüksekti (sırasıyla p= 0,022, p=0,034).
Sonuç: Çalışmamızda, prediyabetli bireylerde 18-FDG PET / BT ile belirlenen glukoz alımının düşük olduğu gösterilmiştir. Bu durum, kahverengi yağ dokusunun tüm vücuttaki glukoz ve enerji dengesi için önemli olabileceğini göstermektedir.
References
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Year 2019,
Volume: 3 Issue: 3, 145 - 148, 31.12.2019
Abstract
References
- 1-Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev. 2004;84:277–359.
- 2. Virtanen KA, Lidell ME, Orava J, et al. Functional brown adipose tissue in healthy adults. N Engl J Med 2009;360:1518–1525
- 3. van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, et al. Coldactivated brown adipose tissue in healthy men. N Engl J Med 2009;360:1500–1508
- 4. Cypess AM, Lehman S, Williams G, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009;360:1509–1517
- 5. Chondronikola M, Volpi E, Borsheim E, et al. Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans. Diabetes. 2014;63:4089–4099.
- 6. Willerson JT, Ridker PM. Inflammation as a cardiovascular risk factor. Circulation. 2004;109:II2– II10.
- 7-Cohade C, Osman M, Pannu HK,Wahl RL. Uptake in supraclavicular area fat (“USA-Fat”): description on 18F-FDG PET/CT. J Nucl Med. 2003;44:170–176.
- 8. Baba S, Jacene HA, Engles JM, Honda H, Wahl RL. CT Hounsfield units of brown adipose tissue increasen with activation: preclinical and clinical studies. J Nucl Med. 2010;51:246–250.
- 9. Boellaard R, Delgado-Bolton R, Oyen WJ, Giammarile F, Tatsch K, Eschner W, Verzijlbergen FJ, Barrington SF, Pike LC, Weber WA, Stroobants S, Delbeke D, Donohoe KJ, Holbrook S, Graham MM, Testanera G, Hoekstra OS, Zijlstra J, Visser E, Hoekstra CJ, Pruim J, Willemsen A, Arends B, Kotzerke J, Bockisch A, Beyer T, Chiti A, Krause BJ. FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0.European Association of Nuclear Medicine (EANM). Eur J Nucl Med Mol Imaging. 2015;42(2):328-354.
- 10. Saito M, Okamatsu-Ogura Y, Matsushita M, et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 2009;58:1526–1531
- 11. Ouellet V, Routhier-Labadie A, Bellemare W, et al. Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans. J Clin Endocrinol Metab 2011;96:192–199
- 12. Matsushita M, Yoneshiro T, Aita S, Kameya T, Sugie H, Saito M. Impact of brown adipose tissue on body fatness and glucose metabolism in healthy humans. Int J Obes (Lond) 2014;38:812–817
- 13. Bartelt A, Bruns OT, Reimer R, et al. Brown adipose tissue activity controls triglyceride clearance. Nat Med 2011;17:200–205
- 14. Stanford KI, Middelbeek RJ, Townsend KL, et al. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J Clin Invest 2013;123:215–223
There are 14 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Research Article |
| Authors | |
| Publication Date | December 31, 2019 |
| Acceptance Date | December 16, 2019 |
| Published in Issue | Year 2019 Volume: 3 Issue: 3 |
Cite
Turkish Journal of Diabetes and Obesity (Turk J Diab Obes) is a scientific publication of Zonguldak Bulent Ecevit University Obesity and Diabetes Research and Application Center.
This is a refereed journal, which is published in printed and electronic forms. It aims at achieving free knowledge to the related national and international organizations and individuals.
This journal is published annually three times (in April, August and December).
The publication language of the journal is Turkish and English.