ASSESSMENT OF ANTIHYPERTENSIVE DRUG INDAPAMIDE GENOTOXICITY IN HUMAN PERIPHERAL LYMPHOCYTES USING CHROMOSOMAL ABERRATION TEST

Year 2017, Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 182 - 182, 16.02.2017

Ece Avuloğlu Yılmaz , Deniz Yüzbaşıoğlu Fatma Ünal

Abstract

Indapamide is an
active ingredient of orally administered diuretic antihypertensive drug.
Genotoxicity data of indapamide are very limited and not detailed (in terms of
doses, treatment period etc.). The purpose of this study was to evaluate the
potential genotoxic effect of indapamide by using in vitro chromosomal
aberration test. For this purpose, peripheral blood obtained from two healthy
young donors, a man and a woman, was treated with four different concentrations
(18,75; 37,50; 75,00 and 100,00 µg/ml) of indapamide in culture conditions for
24 and 48 h. A negative, a solvent (%75 methanol) and a positive control
(mitomycin-C) were also applied for each treatment. According to these results,
indapamide did not affect the frequency of chromosomal aberrations in all the
concentrations and treatment periods. However, there is need to be done other
genotoxicity tests for this active ingredient to support these results. 

Keywords

ASSESSMENT OF ANTIHYPERTENSIVE DRUG INDAPAMIDE GENOTOXICITY IN HUMAN PERIPHERAL LYMPHOCYTES USING CHROMOSOMAL ABERRATION TEST

References

• Ece Avuloğlu YILMAZ, Deniz YÜZBAŞIOĞLU1, Fatma ÜNAL
• Gazi University, Faculty of Science, Department of Biology, Genetic Toxicology Laboratory, Ankara-Turkey