THE EFFECT OF HYPERTENSION AND BODY MASS INDEX ON SISTER CHROMATID EXCHANGE IN MAINTENANCE HEMODIALYSIS PATIENTS WITH CHRONIC KIDNEY FAILURE
Abstract
Chronic kidney failure (CKF) disease is
characterized by progressive loss of kidney function and associated with
increased levels of genomic damage. Hypertension (HT) is a generally risk
factor for progression of renal disease. In developed countries, increased body
mass index (BMI) are associated with CKF. In this study, we investigated the
possible role of HT on genetic damage in maintenance hemodialysis patients with
chronic kidney failure by sister chromatid exchange (SCE) test. Effects of
other factors, such as levels of BMI, age and sex were also evaluated. We
examined 34 CKF patients undergoing hemodialysis. The results showed that there
was no significant difference between the hypertensive (n=7) and
non-hypertensive (n=27), those with body mass index (BMI) levels below (n=24)
and above 25 (g/dL) (n=9), and between males (n=12) and females (n=22) in terms
of sister chromatid exchanges (SCEs) and replication index (RI) in CKD
patients. However, the age value below 50 (n=15) significantly increased the
frequency of sister chromatid exchanges compared to the age value above 50
(n=19). These results suggest that hypertension and body mass index did not
affect the frequency of SCE and RI in chronic kidney failure patients
undergoing hemodialysis
References
- Sevcan MAMUR, Deniz YÜZBAŞIOĞLU, Fatma ÜNAL, Kadriye ALTOK, Serpil Müge DEĞER
- Department of Biology, Polatlı Art and Science Faculty, Gazi University, Ankara, Turkey Genetic Toxicology Laboratory, Department of Biology, Science Faculty, Gazi University, Ankara, Turkey Department of Nephrology, Medical Faculty, Gazi University, Ankara, Turkey
Abstract
References
- Sevcan MAMUR, Deniz YÜZBAŞIOĞLU, Fatma ÜNAL, Kadriye ALTOK, Serpil Müge DEĞER
- Department of Biology, Polatlı Art and Science Faculty, Gazi University, Ankara, Turkey Genetic Toxicology Laboratory, Department of Biology, Science Faculty, Gazi University, Ankara, Turkey Department of Nephrology, Medical Faculty, Gazi University, Ankara, Turkey
Details
| Journal Section | Articles |
|---|---|
| Authors | |
| Publication Date | February 16, 2017 |
| Published in Issue | Year 2017 Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology |
