DETERMINATION OF THE INFLUENCE OF HYPERTENSION, HEMOGLOBIN, AND FERRITIN LEVELS ON DNA DAMAGE BY COMET ASSAY IN HEMODIALYSIS PATIENTS

Year 2017, Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 185 - 185, 16.02.2017

Sevcan Mamur , Deniz Yüzbaşıoğlu Fatma Ünal Kadriye Altok Serpil Müge Değer

Abstract

Chronic kidney
disease (CKD) is an important and growing health problem. Hypertension (HT) is
a generally risk factor for progression of renal disease. In this study, we
investigated to determine the possible role of HT on DNA damage by comet assay
in maintenance hemodialysis patients with chronic kidney disease. Effects of
other factors such as the levels of hemoglobin (HB), ferritin (FER), age, sex
and duration of hemodialysis were also examined. No significant difference was
found on DNA damage between the hypertensive (n=9) and non-hypertensive (n=44),
those with hemoglobin levels below (n=40) and above 12 (g/dL) (n=13), those
with ferritin levels below (n=36) and above 500 ng/ml (n=17), those with a
duration of dialysis treatment below (n=34) and above 5 (n=19) years, those
younger (n=20) and older (n=33) than 50, and between males (n=17) and females
(n=36) in CKD patients. There was a negative correlation between the serum ferritin
level and comet tail length (r=-0.310, p=0.024), however no correlation was
observed in tail intensity. Moreover, there was no correlation between the DNA
damage and the duration of hemodialysis treatment and age among CKD patients.
As a result, age, sex, duration of hemodialysis treatment as well as HT, HB and
FER values did not affect the primary DNA damage.

 

Keywords

DETERMINATION OF THE INFLUENCE OF HYPERTENSION, HEMOGLOBIN

References

• Sevcan MAMUR, Deniz YÜZBAŞIOĞLU, Fatma ÜNAL, Kadriye ALTOK, Serpil Müge DEĞER
• Department of Biology, Polatlı Art and Science Faculty, Gazi University, Ankara, Turkey Genetic Toxicology Laboratory, Department of Biology, Science Faculty, Gazi University, Ankara, Turkey Department of Nephrology, Medical Faculty, Gazi University, Ankara, Turkey